Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patrick K. Quoika"'
Autor:
Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane, Klaus R. Liedl
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAdvances in structural biology and the exponential increase in the amount of high-quality experimental structural data available in the Protein Data Bank has motivated numerous studies to tackle the grand challenge of predicting protein struc
Externí odkaz:
https://doaj.org/article/3a42b424031444ed92eeaed275b5f9d3
Autor:
Patrick K. Quoika, Anna S. Kamenik, Monica L. Fernández-Quintero, Martin Zacharias, Klaus R. Liedl
Publikováno v:
Frontiers in Materials, Vol 10 (2023)
Poly (N-isopropylacrylamide) (PNIPAM) is a famous representative of thermosensitive polymers. Thermosensitive polymers undergo a phase transition with lower critical solution temperature. Commonly, their phase behavior is linked to a conformational c
Externí odkaz:
https://doaj.org/article/277199a959b6451a8d6256f866c0fca0
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/863a1215e8194a08a42b208a8195a801
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy. When designing new formats, a target
Externí odkaz:
https://doaj.org/article/54e0f0f4d5ce4f6eb11bbfda2d108352
Autor:
Monica L. Fernández-Quintero, Katharina B. Kroell, Lisa M. Bacher, Johannes R. Loeffler, Patrick K. Quoika, Guy Georges, Alexander Bujotzek, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 differe
Externí odkaz:
https://doaj.org/article/c9ed751bd030469cb8cfaa67c3de38a9
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system. As part of their humoral adaptive immune response, they produce an immunoglobulin, the so-called immuno
Externí odkaz:
https://doaj.org/article/acb8d402a0bc4a56a914f99ef4d7bd83
Autor:
Johannes R. Loeffler, Monica L. Fernández-Quintero, Franz Waibl, Patrick K. Quoika, Florian Hofer, Michael Schauperl, Klaus R. Liedl
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Stacking interactions play a crucial role in drug design, as we can find aromatic cores or scaffolds in almost any available small molecule drug. To predict optimal binding geometries and enhance stacking interactions, usually high-level quantum mech
Externí odkaz:
https://doaj.org/article/847f7b15f2434a2abab43b743e1d3e84
Autor:
Monica L. Fernández-Quintero, Katharina B. Kroell, Martin C. Heiss, Johannes R. Loeffler, Patrick K. Quoika, Franz Waibl, Alexander Bujotzek, Ekkehard Moessner, Guy Georges, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Fab consist of a heavy and light chain and can be subdivided into a variable (VH and VL) and a constant region (CH1 and CL). The variable region contains the complementarity-determining region (CDR), which is formed by six hypervariable loops, shapin
Externí odkaz:
https://doaj.org/article/17bd5b59030048158efa6156e20c1d2f
Autor:
Nancy D. Pomarici, Franz Waibl, Patrick K. Quoika, Alexander Bujotzek, Guy Georges, Monica L. Fernández-Quintero, Klaus R. Liedl
Publikováno v:
Journal of Computer-Aided Molecular Design. 37:201-215
Therapeutic antibodies should not only recognize antigens specifically, but also need to be free from developability issues, such as poor stability. Thus, the mechanistic understanding and characterization of stability are critical determinants for r
Autor:
Dennis F. Dinu, Pit Bartl, Patrick K. Quoika, Maren Podewitz, Klaus R. Liedl, Hinrich Grothe, Thomas Loerting
Publikováno v:
The Journal of Physical Chemistry A. 126:2966-2975