Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Patrick K. McCamphill"'
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://doaj.org/article/d876a8e8eb874f5ea370bbe486d1786b
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2021)
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cabe950f76a8dbaa7e70008b20d765f
https://doi.org/10.3389/fpsyt.2021.718953
https://doi.org/10.3389/fpsyt.2021.718953
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9eaf9ceed2a26bd3c85ce14adec3a4
https://doi.org/10.1101/2021.07.02.450894
https://doi.org/10.1101/2021.07.02.450894
Autor:
Jon M. Madison, Patrick K. McCamphill, David C. Stoppel, Xi Shi, Michael C. Lewis, Katie A. Collins, Mark F. Bear, Florence F. Wagner, Edward M. Scolnick, Vinay Sridhar, Rebecca K Senter, Kimberly M. Huber, Jen Q. Pan, Arnold J. Heynen, Jeffrey R. Cottrell, Laura J. Stoppel, Edward B. Holson
Publikováno v:
Sci Transl Med
PMC
PMC
Copyright © 2020 The Authors, some rights reserved. Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1-/y mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8122766232f611e1a4cab76f0622ee16
https://doi.org/10.1126/scitranslmed.aam8572
https://doi.org/10.1126/scitranslmed.aam8572
Publikováno v:
Journal of Neurochemistry. 142:246-259
Mechanistic target of rapamycin complex 1 (mTORC1)-dependent protein synthesis is required for many forms of synaptic plasticity and memory, but the downstream pathways important for synaptic plasticity are poorly understood. Long-term facilitation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757dd1ac526f1de7cd9e25689a3ad324
https://doi.org/10.1111/jnc.14030
https://doi.org/10.1111/jnc.14030
Publikováno v:
The Journal of Neuroscience. 35:4403-4417
At the sensory-motor neuron synapse ofAplysia, either spaced or continuous (massed) exposure to serotonin (5-HT) induces a form of intermediate-term facilitation (ITF) that requires new protein synthesis but not gene transcription. However, spaced an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c3826c28dea48108292b330d11e9c7
https://doi.org/10.1523/jneurosci.2376-14.2015
https://doi.org/10.1523/jneurosci.2376-14.2015
Publikováno v:
The Journal of Neuroscience. 35:8039-8041
Basic region leucine zipper (bZIP) transcription factors regulate gene expression critical for long-term synaptic plasticity or neuronal excitability contributing to learning and memory. At sensorimotor synapses of Aplysia, changes in activation or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c212a1601c2f55ecccd9b85166cb6a8
https://doi.org/10.1523/jneurosci.0897-15.2015
https://doi.org/10.1523/jneurosci.0897-15.2015
Autor:
Tyler W. Dunn, Xiaotang Fan, Wayne S. Sossin, Patrick K. McCamphill, Eugenia Pethoukov, Daniel B. Weatherill
Publikováno v:
Journal of Neurochemistry. 117:841-855
Long-term facilitation (LTF) in Aplysia is a leading model for elucidating the biochemical mechanisms of synaptic plasticity underlying learning. LTF requires translational control downstream of target of rapamycin complex 1. Our lab has previously s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb1aaa906b78a20646a64a80061859b
https://doi.org/10.1111/j.1471-4159.2011.07251.x
https://doi.org/10.1111/j.1471-4159.2011.07251.x
Publikováno v:
Learningmemory (Cold Spring Harbor, N.Y.). 20(10)
Mechanistic target of rapamcyin (mTOR) is a central player in cell growth throughout the organism. However, mTOR takes on an additional, more specialized role in the developed neuron, where it regulates the protein synthesis-dependent, plastic change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135d25244805bcf948bd9aaacdd41652
https://pubmed.ncbi.nlm.nih.gov/24042848
https://pubmed.ncbi.nlm.nih.gov/24042848
Publikováno v:
Neuromethods ISBN: 9781627035163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0928d6bef626d4ae34a7e9a672fcd5
https://doi.org/10.1007/978-1-62703-517-0_3
https://doi.org/10.1007/978-1-62703-517-0_3