Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Patrick K. Clark"'
Autor:
Andrea L. Ferris, Robin Dewar, Frank Maldarelli, JoAnn M. Mican, Margaret R Caplan, Paul L. Boyer, Patrick K. Clark, Adam Johnson, Michael C. Sneller, Catherine Rehm, Stephen H. Hughes
Publikováno v:
Antimicrob Agents Chemother
Resistance to anti-Human Immunodeficiency Virus (HIV) drugs has been a problem from the beginning of antiviral drug treatments. The recent expansion of combination antiretroviral therapy worldwide has led to an increase in resistance to antiretrovira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80b03999969d8d74917a922a177113e
https://pubmed.ncbi.nlm.nih.gov/34723625
https://pubmed.ncbi.nlm.nih.gov/34723625
Publikováno v:
PLoS Pathogens, Vol 2, Iss 2, p e10 (2006)
The human immunodeficiency virus type 1 (HIV-1) develops resistance to all available drugs, including the nucleoside analog reverse transcriptase inhibitors (NRTIs) such as AZT. ATP-mediated excision underlies the most common form of HIV-1 resistance
Externí odkaz:
https://doaj.org/article/470470b2951c498e8ffe1006c340461b
Autor:
Patrick K. Clark, Alan Rein, Yun-Xing Wang, Demetria Harvin, Ruth Nussinov, Lixin Fan, Buyong Ma, Raymond Sowder, Siddhartha A. K. Datta
Publikováno v:
Journal of Virology. 90:1773-1787
HIV-1 immature particle (virus-like particle [VLP]) assembly is mediated largely by interactions between the capsid (CA) domains of Gag molecules but is facilitated by binding of the nucleocapsid (NC) domain to nucleic acid. We previously investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67816f2f06acecfb83c05e4e1d1ae31c
https://doi.org/10.1128/jvi.02061-15
https://doi.org/10.1128/jvi.02061-15
Publikováno v:
Journal of Virology. 86:5885-5894
As anti-HIV therapy becomes more widely available in developing nations, it is clear that drug resistance will continue to be a major problem. The related viruses HIV-1 and HIV-2 share many of the same resistance pathways to nucleoside reverse transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15917511d45ab81cf94b190e762098b
https://doi.org/10.1128/jvi.06597-11
https://doi.org/10.1128/jvi.06597-11
Autor:
Yun-Xing Wang, Alan Rein, Patrick K. Clark, Siddhartha A. K. Datta, Xiaobing Zuo, Stephen J. Campbell
Publikováno v:
Journal of Virology. 85:12733-12741
Immature retrovirus particles are assembled from the multidomain Gag protein. In these particles, the Gag proteins are arranged radially as elongated rods. We have previously characterized the properties of HIV-1 Gag in solution. In the absence of nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7b46a4711a66e58133a315693413fd
https://doi.org/10.1128/jvi.05889-11
https://doi.org/10.1128/jvi.05889-11
Autor:
Eun Gyung Lee, Maxine L. Linial, Jacqueline Roy, Patrick K. Clark, Stephen H. Hughes, Paul L. Boyer, Dana L. Jackson
Publikováno v:
Journal of Virology. 85:1655-1661
Unlike orthoretroviruses, foamy retroviruses (FV) synthesize Pol independently of Gag. The FV Pol precursor is cleaved only once between reverse transcriptase (RT) and integrase (IN) by the protease (PR), resulting in a PR-RT and an IN protein. Only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f06c5b86ff97f212f6ea8d58ffd6ba1
https://doi.org/10.1128/jvi.01873-09
https://doi.org/10.1128/jvi.01873-09
Autor:
Jeremy L. Goodin, David F. Nellis, Bradford S. Powell, Vinay V. Vyas, Jeffrey T. Enama, Lena C. Wang, Patrick K. Clark, Steven L. Giardina, Jeffery. J. Adamovicz, Dennis F. Michiel
Publikováno v:
Protein Expression and Purification. 53:63-79
The F1-V vaccine antigen, protective against Yersinia pestis, exhibits a strong tendency to multimerize that affects larger-scale manufacture and characterization. In this work, the sole F1-V cysteine was replaced with serine by site-directed mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cebc246cf774dc19892430d19b94f8
https://doi.org/10.1016/j.pep.2006.12.018
https://doi.org/10.1016/j.pep.2006.12.018
Autor:
Mohammed M. Hossain, Karsten Krogh-Jespersen, Patrick K. Clark, Sanjeewa Dharmasena, Ronald M. Levy, Michael A. Parniak, Daniel M. Himmel, John G. Julias, Kessler McCoy-Simandle, Stephen H. Hughes, Tatiana V Ilina, Arthur D. Clark, Jennifer L. Knight, Eddy Arnold, Stefan G. Sarafianos
Publikováno v:
ACS Chemical Biology. 1:702-712
The rapid emergence of drug-resistant variants of human immunodeficiency virus, type 1 (HIV-1), has limited the efficacy of anti-acquired immune deficiency syndrome (AIDS) treatments, and new lead compounds that target novel binding sites are needed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0954aaf9258be68dbaba7436420c0e34
https://doi.org/10.1021/cb600303y
https://doi.org/10.1021/cb600303y
Autor:
Paul L. Boyer, H. Maarten Vinkers, Robert W. Kavash, Marie Pierre de Béthune, Eddy Arnold, Patrick K. Clark, Jan Heeres, Donald William Ludovici, Paul A. J. Janssen, Lucien Maria Henricus Koymans, Michael J. Kukla, Koen Andries, Mark A. Lichtenstein, Rudi Pauwels, Paul J. Lewi, Bart De Corte, Chih Y. Ho, Hong Ye, Marc René De Jonge, Kalyan Das, Arthur D. Clark, Frederik Frans Desire Daeyaert, Stephen H. Hughes
Publikováno v:
Journal of medicinal chemistry
Anti-AIDS drug candidate and non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC125-R165335 (etravirine) caused an initial drop in viral load similar to that observed with a five-drug combination in naïve patients and retains potency in patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc9dc655084ffbe3967e59862aff25d
https://doi.org/10.1021/jm030558s
https://doi.org/10.1021/jm030558s
Autor:
Jane M. Sayer, Donald M. Jerina, Elena N. Peletskaya, Patrick K. Clark, Stephen H. Hughes, Alex A. Kogon, Paul L. Boyer, Heiko Kroth
Publikováno v:
Journal of Virology. 75:9435-9445
Cross-linking experiments were performed with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (positions 65, 67, 70, and 74) in the fingers subdomain of the p66 subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57d1a9f3e836983c3419b51027624ff
https://doi.org/10.1128/jvi.75.19.9435-9445.2001
https://doi.org/10.1128/jvi.75.19.9435-9445.2001