Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Patrick K, Chaffey"'
Autor:
Yaohao, Li, Xiaoyang, Guan, Patrick K, Chaffey, Yuan, Ruan, Bo, Ma, Shiying, Shang, Michael E, Himmel, Gregg T, Beckham, Hai, Long, Zhongping, Tan
Publikováno v:
Chemical Science
Improved understanding of the effect of protein glycosylation is expected to provide the foundation for the design of protein glycoengineering strategies. In this study, we examine the impact of O-glycosylation on the binding selectivity of a model F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cda632c70ef69418c46021da3ad9772
https://pubmed.ncbi.nlm.nih.gov/34123172
https://pubmed.ncbi.nlm.nih.gov/34123172
Autor:
Gregg T. Beckham, Yaohao Li, Munir S. Skaf, Zhongping Tan, Xiaoyang Guan, Michael F. Crowley, Patrick K. Chaffey, Erica T. Prates, Xinfeng Wang
Publikováno v:
Chemical Science. 9:3710-3715
Protein glycosylation is a diverse post-translational modification that serves myriad biological functions. O-linked glycans in particular vary widely in extent and chemistry in eukaryotes, with secreted proteins from fungi and yeast commonly exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c21d7ef3c9803b9ad92598a709ce1df
https://doi.org/10.1039/c7sc05016j
https://doi.org/10.1039/c7sc05016j
Autor:
Yuan Ruan, Jaimie Zhu, Liu Meng Yang, Amy H. Tran, Yaohao Li, Xiuli Wei, Xu Wang, Patrick K. Chaffey, Wei Feng, Yong-Tang Zheng, Zhongping Tan, Wei Liang, Huan Chen, Xinfeng Wang, Xiaoyang Guan, Kimberly B. Barosh
Publikováno v:
Biochemistry. 57:136-148
Many human proteins have the potential to be developed as therapeutic agents. However, side effects caused by direct administration of natural proteins have significantly slowed expansion of protein therapeutics into the clinic. Post-translational mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9316c9739b571c7c1c6221e32b34cb98
https://doi.org/10.1021/acs.biochem.7b00875
https://doi.org/10.1021/acs.biochem.7b00875
Autor:
Yaohao Li, Zhongping Tan, Patrick K. Chaffey, Yuan Ruan, Amy H. Tran, Lomax F Pass, Theo N Koelsch, Xiaoyang Guan, Xinfeng Wang, Suzannah G Miller
Publikováno v:
Biochemistry. 56:4539-4548
Protein O-glycosylation is a diverse, common, and important post-translational modification of both proteins inside the cell and those that are secreted or membrane-bound. Much work has shown that O-glycosylation can alter the structure, function, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6ee2cc3f98d518cddceca8b63816d2
https://doi.org/10.1021/acs.biochem.7b00483
https://doi.org/10.1021/acs.biochem.7b00483
Autor:
Patrick K. Chaffey, Connor K. Hurd, Xiaoyang Guan, Zhongping Tan, Yuan Ruan, Dylan J. Taatjes
Publikováno v:
Synlett. 28:1917-1922
Phosphorylation of the N-terminal transactivation domain (TAD) of tumor suppressor p53 (p53TAD) helps regulate many of p53’s biological functions. Chemical synthesis of the p53TAD sequence with various phosphorylation patterns, through native chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f7ee001419e5a8ee311edcb7b60e63
https://doi.org/10.1055/s-0036-1590834
https://doi.org/10.1055/s-0036-1590834
Autor:
Yuan Ruan, Theo N Koelsch, Amy H. Tran, Xiaoyang Guan, Chao Chen, Xinfeng Wang, Zhongping Tan, Qiu Cui, Yingang Feng, Patrick K. Chaffey
Publikováno v:
Biochemistry. 56:2897-2906
Protein glycosylation has been shown to have a variety of site-specific and glycan-specific effects, but so far, the molecular logic that leads to such observations has been elusive. Understanding the structural changes that occur and being able to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8194c07594d58a7edbed0ba54fe7f9e
https://doi.org/10.1021/acs.biochem.7b00195
https://doi.org/10.1021/acs.biochem.7b00195
Publikováno v:
Biochemistry. 57(4)
Protein glycosylation is one of the most common post-translational modifications and can influence many properties of proteins. Abnormal protein glycosylation can lead to protein malfunction and serious disease. While appreciation of glycosylation's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23309ccd407127427ccea63d37d5154f
https://pubmed.ncbi.nlm.nih.gov/29309128
https://pubmed.ncbi.nlm.nih.gov/29309128
Molecular-scale features that govern the effects of O-glycosylation on a carbohydrate-binding module
Autor:
Patrick K. Chaffey, Ari Groobman, Zhongping Tan, Gregg T. Beckham, Xiaoyang Guan, Michael E. Himmel, Eric R. Greene, Chen Zeng, Liqun Chen, Matthew R. Drake, Claire Chen, Michael G. Resch
Publikováno v:
Chemical Science. 6:7185-7189
Protein glycosylation is a ubiquitous post-translational modification in all kingdoms of life. Despite its importance in molecular and cellular biology, the molecular-level ramifications of O-glycosylation on biomolecular structure and function remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d1867df58bb616e1bf98395d40f04c
https://doi.org/10.1039/c5sc02636a
https://doi.org/10.1039/c5sc02636a
Autor:
Daniel R. Gulbranson, Chen Zeng, Xiaoyang Guan, Wei Liang, Theo N Koelsch, Yuan Ruan, Liqun Chen, Yan Ouyang, Xiuli Wei, Yaohao Li, Xinfeng Wang, Zhongping Tan, Patrick K. Chaffey, Jingshi Shen, Amy H. Tran
Diabetes is a leading cause of death worldwide and results in over 3 million annual deaths. While insulin manages the disease well, many patients fail to comply with injection schedules and, despite significant investment, a more convenient oral form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e922115e3da163b5a18129c8eaea5f7
https://europepmc.org/articles/PMC6287623/
https://europepmc.org/articles/PMC6287623/
Publikováno v:
Chemical Biology of Glycoproteins ISBN: 9781782623335
Protein glycosylation, the covalent attachment of carbohydrates to amino acid side chains of proteins, is a ubiquitous post-translational modification across all branches of life. Due to many factors, including the vast structural complexity of glyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a78a6c0ceed7a7d7fb66f05626a69bc
https://doi.org/10.1039/9781782623823-00048
https://doi.org/10.1039/9781782623823-00048