Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Patrick J. Whelan"'
Autor:
Sandeep Sharma, Cecilia A. Badenhorst, Donovan M. Ashby, Stephanie A. Di Vito, Michelle A. Tran, Zahra Ghavasieh, Gurleen K. Grewal, Cole R. Belway, Alexander McGirr, Patrick J. Whelan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cuneiform nucleus (CnF) regulates locomotor activity, which is canonically viewed as being primarily involved in initiating locomotion and regulating speed. Recent research shows greater context dependency in the locomotor functions of t
Externí odkaz:
https://doaj.org/article/1c74346562b3406a8373f34dd6788ab5
Autor:
Brian R. Noga, Patrick J. Whelan
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat. It was functionally defined based on the ability of low threshold electrical stimuli within a region comprising the cuneiform and pedunculopontine nucleus to evok
Externí odkaz:
https://doaj.org/article/ab9b2a5fa7dc40618975fbf6bb6d82df
Autor:
Simon A. Sharples, Jessica Parker, Alex Vargas, Jonathan J. Milla-Cruz, Adam P. Lognon, Ning Cheng, Leanne Young, Anchita Shonak, Gennady S. Cymbalyuk, Patrick J. Whelan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Externí odkaz:
https://doaj.org/article/747aa073fb3f4e11a9b95496b04eadd5
Autor:
Kathrin Koblinger, Céline Jean-Xavier, Sandeep Sharma, Tamás Füzesi, Leanne Young, Shane E. A. Eaton, Charlie Hong Ting Kwok, Jaideep Singh Bains, Patrick J. Whelan
Publikováno v:
Frontiers in Neural Circuits, Vol 12 (2018)
Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the po
Externí odkaz:
https://doaj.org/article/ca7b1618b8144fb788a973f0ba1be452
Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors
Autor:
Linda H. Kim, Sandeep Sharma, Simon A. Sharples, Kyle A. Mayr, Charlie H. T. Kwok, Patrick J. Whelan
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating
Externí odkaz:
https://doaj.org/article/01022b7774314325a6f93ec341720c07
Autor:
Simon A, Sharples, Jessica, Parker, Alex, Vargas, Jonathan J, Milla-Cruz, Adam P, Lognon, Ning, Cheng, Leanne, Young, Anchita, Shonak, Gennady S, Cymbalyuk, Patrick J, Whelan
Publikováno v:
Frontiers in cellular neuroscience. 15
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Publikováno v:
Current Opinion in Physiology. 8:70-75
Understanding the neural basis for locomotion is of critical importance since it subserves many behaviours necessary for survival. The spinal cord contains all the elements required to produce the basic locomotor pattern. These elements which compose
Autor:
Tuan Trang, Céline Jean-Xavier, Simon A. Sharples, Joanna Borowska-Fielding, Shane E. A. Eaton, Ying Zhang, Nicole E. Burma, Charlie H.T. Kwok, Patrick J. Whelan, Glen B. Baker
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-23 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-23 (2020)
Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D1 and D2 receptors respectively. The spinal cord also expresses all dopamine receptors however; how the specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6a70c1d76fa1e5ad95a164839e3852
https://hdl.handle.net/10023/20730
https://hdl.handle.net/10023/20730
Autor:
Ning Cheng, Adam P. Lognon, Jessica Parker, Leanne Young, Gennady Cymbalyuk, Patrick J. Whelan, Alex Vargas, Anchita Shonak, Simon A. Sharples
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns of rhythmic activity. Variation in excitability state and neuromodulatory tone can facilitate transitions between episodic and continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac4ecb7175fa93070bcd503fc8ae965
https://doi.org/10.1101/2020.09.08.288266
https://doi.org/10.1101/2020.09.08.288266
Autor:
Fatima Memic, Henrik Boije, Leif C. Andersson, Patrick J. Whelan, Klas Kullander, Taha Chersa, Michelle A. Tran, Anna Velica, Jennifer Vieillard, Nadine Bernhardt
Identifying the spinal circuits controlling locomotion is critical for unravelling the mechanisms controlling the production of gaits. Development of the circuits governing left-right coordination relies on axon guidance molecules such as ephrins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b413e3bed0cc9d2821bd9824b57a51dc