Výsledky vyhledávání - "Patrick J. Westfall"

Analysis of Mitogen-Activated Protein Kinase Signaling Specificity in Response to Hyperosmotic Stress: Use of an Analog-Sensitive HOG1 Allele

Autor: Jeremy Thorner, Patrick J. Westfall

Publikováno v: Eukaryotic Cell. 5:1215-1228

When confronted with a marked increase in external osmolarity, budding yeast ( Saccharomyces cerevisiae ) cells utilize a conserved mitogen-activated protein kinase (MAPK) signaling cascade (the high-osmolarity glycerol or HOG pathway) to elicit cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a73aef848f13b9b5a028abd93d741c
https://doi.org/10.1128/ec.00037-06

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Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Autor: David J. Melis, Michael D. Leavell, Chris J. Paddon, Diana Eng, Tizita Horning, Jack D. Newman, Neil Stephen Renninger, Jay D. Keasling, Jacob R. Lenihan, Patrick J. Westfall, Rika Regentin, Derek McPhee, Andrew Owens, Frank X. Woolard, Kirsten R. Benjamin, Scott Fickes, Don Diola, Douglas J. Pitera, Hiroko Tsuruta

Publikováno v: Proceedings of the National Academy of Sciences. 109

Malaria, caused by Plasmodium sp , results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3795724f56b96b08013cbfd35bfacf3f
https://doi.org/10.1073/pnas.1110740109

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Microbially Derived Semisynthetic Artemisinin

Autor: Patrick J. Westfall, Derek McPhee, Christopher J. Paddon, Jack D. Newman, Douglas J. Pitera, Kirsten R. Benjamin, Karl Fisher, Michael D. Leavell, Rika Regentin, Scott Fickes

Publikováno v: Isoprenoid Synthesis in Plants and Microorganisms ISBN: 9781461440628

Artemisinin is a sesquiterpene lactone endoperoxide with potent antimalarial properties, recommended by the World Health Organization for the treatment of malaria in artemisinin combination therapies (ACTs). It is extracted from the plant Artemisia a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2f7c395299484146814ac7e3c7bd77
https://doi.org/10.1007/978-1-4614-4063-5_7

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Stress resistance and signal fidelity independent of nuclear MAPK function

Autor: Patrick J. Westfall, Jeremy Thorner, Jesse C. Patterson, Raymond E. Chen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(34)

Elevated external solute stimulates a conserved MAPK cascade that elicits responses that maintain osmotic balance. The yeast high-osmolarity glycerol (HOG) pathway activates Hog1 MAPK (mammalian ortholog p38α/SAPKα), which enters the nucleus and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57560313182bf848e907829bf4cd537a
https://pubmed.ncbi.nlm.nih.gov/18719124

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When the stress of your environment makes you go HOG wild

Autor: Jeremy Thorner, Daniel R. Ballon, Patrick J. Westfall

Publikováno v: Science (New York, N.Y.). 306(5701)

When exposed to increased dissolved solute in their environment (hyperosmotic stress), all eukaryotic cells respond by rapidly activating a conserved mitogen-activated protein kinase cascade, known in budding yeast Saccharomyces cerevisiae as the hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cab6c09caa924434d0ed09377d6ebd5
https://pubmed.ncbi.nlm.nih.gov/15567851

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Aspergillus nidulans septin AspB plays pre- and postmitotic roles in septum, branch, and conidiophore development

Autor: Michelle Momany, Patrick J. Westfall

Publikováno v: Molecular biology of the cell. 13(1)

Members of the septin family of proteins act as organizational scaffolds in areas of cell division and new growth in a variety of organisms. Herein, we show that in the filamentous fungusAspergillus nidulans, the septin AspB is important for cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23709f9072fbe6f7ddc8c2b3be1d5c4
https://pubmed.ncbi.nlm.nih.gov/11809826

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Characterization of the Aspergillus nidulans septin (asp) gene family

Autor: Michelle Momany, Jiong Zhao, Patrick J. Westfall, Rebecca Lindsey

Publikováno v: Genetics. 157(3)

Members of the septin gene family are involved in cytokinesis and the organization of new growth in organisms as diverse as yeast, fruit fly, worm, mouse, and human. Five septin genes have been cloned and sequenced from the model filamentous fungus A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d329746c112ca6893e53dbb8f11dce
https://pubmed.ncbi.nlm.nih.gov/11238387

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