Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Patrick J. Schultheis"'
Autor:
John G. Holden, Osunde R. Ekhator, Sheila M. Fleming, Patrick J. Schultheis, Emily R. Dirr, Rachel Blackwood, Eliezer Masliah
Publikováno v:
Behavioural Brain Research. 343:41-49
Loss of function mutations in the gene ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis, the former designated as an inherited form of Parkinson’s disease (PD). The function of ATP13A2 is unclear but in vitro stud
Autor:
Shanta Pamphile, Andrew Lemkuhl, Jerome A. Roth, Nicholas A. Santiago, Elizabeth J. Mullin, Osunde R. Ekhator, Patrick J. Schultheis, Sheila M. Fleming, Stephen C. Linn, Ying Sun, Diana S. Aga, Gary E. Shull, Swagata Karkare, Benjamin Liou, John G. Holden
Publikováno v:
Neurotoxicology
Loss of function mutations in the P5-ATPase ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis. While the function of ATP13A2 is unclear, in vitro studies suggest it is a lysosomal protein that interacts with the meta
Publikováno v:
Yeast. 33:43-53
Saccharomyces cerevisiae was the first eukaryotic organism to be sequenced; however, little progress has been made in recent years in furthering our understanding of all open reading frames (ORFs). From October 2012 to May 2015 the number of verified
Autor:
Patrick J. Schultheis, Kristi L. Haik, Petra Henrich-Noack, Hanna N. Wetzel, Bernhard A. Sabel, Ruth Hemmer, Robert Spaulding, Richard L. Boyce, Andrew M Hall, Joseph Curcio, Sarah K. Pixley, Tracy Hopkins
Publikováno v:
Journal of drug targeting. 24(7)
Background Poly(butylcyanoacrylate) (PBCA) nanoparticles (NPs) loaded with doxorubicin (DOX) and coated with polysorbate 80 (PS80) have shown efficacy in the treatment of rat glioblastoma. However, cytotoxicity of this treatment remains unclear. Purp
Publikováno v:
Neurobiology of Learning and Memory. 95:64-72
Previous research has indicated that the blockade of H(3)-type histamine receptors may improve attention and memory in normal rodents. The purpose of this study was to determine if ciproxifan, an H(3) receptor antagonist, could alleviate the hyperact
Publikováno v:
Yeast (Chichester, England). 33(2)
Saccharomyces cerevisiae was the first eukaryotic organism to be sequenced; however, little progress has been made in recent years in furthering our understanding of all open reading frames (ORFs). From October 2012 to May 2015 the number of verified
Autor:
Ian R. van Driel, Patrick J. Schultheis, Zachary Spicer, Anastasia Andringa, Marian L. Miller, Louise M. Judd, Sheila M. Bell, Michael Flagella, Gary E. Shull
Publikováno v:
Cell and Tissue Research. 309:369-380
Ion transporters play a central role in gastric acid secretion. To determine whether some of these transporters are necessary for the normal ultrastructure of secretory membranes in gastric parietal cells, mice lacking transporters for H+, K+, Cl-, a
Autor:
Anne Mette Sorensen, Gary E. Shull, Mark A. Knepper, Heddwen L. Brooks, James Terris, John N. Lorenz, Patrick J. Schultheis
Publikováno v:
The Journal of Physiology. 530:359-366
The Na+–H+ exchanger NHE3 and the thiazide-sensitive Na+–Cl− cotransporter NCC are the major apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively. We investigated the mechanis
Autor:
Jeong Taeg Seo, Min Goo Lee, Joo Young Choi, Gary E. Shull, Xiang Luo, Kyung Hwan Kim, Shmuel Muallem, Wooin Ahn, Patrick J. Schultheis
Publikováno v:
Journal of Clinical Investigation. 105:1651-1658
To study the roles of Na(+)-dependent H(+) transporters, we characterized H(+) efflux mechanisms in the pancreatic duct in wild-type, NHE2(-/-), and NHE3(-/-) mice. The pancreatic duct expresses NHE1 in the basolateral membrane, and NHE2 and NHE3 in
Autor:
Patrick J. Schultheis, Shmuel Muallem, Michel Baum, Mehul Shah, Gary E. Shull, Min Goo Lee, Joo Young Choi
Publikováno v:
Journal of Clinical Investigation. 105:1141-1146
The proximal convoluted tubule (PCT) reabsorbs most of the filtered bicarbonate. Proton secretion is believed to be mediated predominantly by an apical membrane Na(+)/H(+) exchanger (NHE). Several NHE isoforms have been cloned, but only NHE3 and NHE2