Výsledky vyhledávání - "Patrick J. Scannon"

Akademický článek

Pilot experience with opebacan/rBPI21 in myeloablative hematopoietic cell transplantation [version 1; referees: 2 approved]

Autor: Eva Guinan, David E Avigan, Robert J Soiffer, Nancy J Bunin, Lisa L Brennan, Ilana Bergelson, Spencer Brightman, Al Ozonoff, Patrick J Scannon, Ofer Levy

Publikováno v: F1000Research, Vol 4 (2015)

Bacterial infection and inflammation contribute significantly to the morbidity and mortality of myeloablative allogeneic hematopoietic cell transplantation (HCT). Endotoxin, a component of the outer membrane of Gram-negative bacteria, is a potent inf

Externí odkaz: https://doaj.org/article/38a21c9830564e2d829e4fd9bc79c3cd

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Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study

Autor: Ahmet Gül, Bahar Artım Esen, Charles A. Dinarello, Alan M. Solinger, Leonid L. Reznikov, A. M. Mirza, Patrick J. Scannon, Ilknur Tugal-Tutkun

Publikováno v: Annals of the Rheumatic Diseases. 71:563-566

Objective Uveitis and retinal vasculitis are sight-threatening manifestations of Behcet9s disease with limited treatment options. This pilot study aimed to evaluate the safety, pharmacokinetics and clinical activity of XOMA 052 (gevokizumab), a recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8aa9a4f962a3ad8ecd2098a8b1376f5
https://doi.org/10.1136/annrheumdis-2011-155143

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Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders

Autor: Hassan Issafras, Ira D. Goldfine, Daniel Bedinger, Paul Rubin, Mark L. White, John Corbin, Vinay Bhaskar, Patrick J. Scannon

Publikováno v: Journal of diabetes science and technology. 8(4)

Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In contrast, the use of antibodies to target receptors at allosteric sites (distinct from the orthost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43022acff0c11221f04cd5d666cf716a
https://pubmed.ncbi.nlm.nih.gov/24876415

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Bactericidal/permeability-increasing protein—Lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia

Autor: Patrick J. Scannon, Brett P. Giroir, Michael Levin

Publikováno v: Critical Care Medicine. 29:S130-S135

Objectives: To review the scientific rationale for the clinical use of recombinant bactericidal permeability-increasing protein (rBPI 21 ) and to discuss the results, implications, and lessons learned during the clinical development of rBPI 21 for ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92518790245a2c346bde0927a3873df1
https://doi.org/10.1097/00003246-200107001-00039

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Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial

Autor: Phil Barton, Brett P. Giroir, Peter A. Quint, Sam D. Shemie, Michael Levin, Patrick J. Scannon, John S. Bradley, Sun Sook Kim, Brahm Goldstein, Daniel P Cafaro, Timothy Yeh

Publikováno v: The Lancet. 356:961-967

Summary Background Endotoxin is a primary trigger of the inflammatory processes that lead to shock, multiorgan failure, and purpura fulminans in meningococcal sepsis. Bactericidal/permeability-increasing protein (BPI) is a natural protein, stored wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e93a7f5c10992052b90ae55880b9c53
https://doi.org/10.1016/s0140-6736(00)02712-4

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Recombinant 21 kDa N-terminal fragment of human bactericidal/permeability-increasing protein (rBPI21): progress in the clinic

Autor: Patrick J. Scannon

Publikováno v: Journal of Endotoxin Research. 5:209-212

rBPI21 is a recombinant 193 amino acid protein derived from human BPI, a naturally occurring 456 amino acid host defense molecule made in neutrophils. rBPI21 possesses multiple properties which include binding, clearing and neutralizing bacterial end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6abc8fa48a3680a69b5506c305359bb6
https://doi.org/10.1177/09680519990050040801

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Bactericidal/Permeability-Increasing Protein (rBPI21) in Patients with Hemorrhage Due to Trauma

Autor: Betty J. Nelson, Demetrios Demetriades, J. Stanley Smith, Joseph P. Minei, Lewis E. Jacobson, Michael Moncure, Patrick J. Scannon

Publikováno v: The Journal of Trauma: Injury, Infection, and Critical Care. 46:667-676

BackgroundInfection and organ failure are the most common causes of death or serious complication in trauma patients surviving initial resuscitation and operation. Of the many possible causes of these complications, bacterial translocation and releas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e04bb95baa4062999437085bf5eb637
https://doi.org/10.1097/00005373-199904000-00018

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Preoperative and postoperative endotoxemia in children with congenital heart disease

Autor: Mark L. White, Patrick J. Scannon, Laurance L. Lequier, Steven R. Leonard, Brett P. Giroir, Joni L. Bokovoy, Hisashi Nikaidoh

Publikováno v: Chest. 117(6)

Recent data indicate that increases in inflammatory cytokines are seen in patients with diverse cardiac diseases. However, the primary stimulus for cytokine secretion during cardiac illness remains unknown. Since bacterial endotoxin is a potent induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40490faf33a8a08ee3eee177a00126d
https://pubmed.ncbi.nlm.nih.gov/10858406

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Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock

Autor: Mark L. White, Steven M. Opal, Nicolas A. Parejo, John E. Palardy, Jean Louis Vincent, John Pribble, Stephen F. Carroll, Jon H. Lemke, Patrick J. Scannon

Publikováno v: The Journal of infectious diseases. 180(5)

Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic shock. Endotoxin levels were significantly greater than control levels (n=33; mean +/- SD, 5.1+/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dd3f11faa6ad792d5ecba715c9d490
https://pubmed.ncbi.nlm.nih.gov/10515819

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Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis

Autor: Nancy Wedel, Louann Kitchen, Brett P. Giroir, Erica A. Kirsch, Brahm Goldstein, Patrick J. Scannon, Peter A. Quint, Betty J. Nelson, Phil Barton, Stephen F. Carroll

Publikováno v: Lancet (London, England). 350(9089)

Summary Background Meningococcal sepsis remains an important cause of morbidity and mortality. We hypothesised that children with severe meningococcaemia might benefit from inhibition of the inflammatory processes thought responsible for fulminant di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc4f1c9837258c225dbc861ed30f194
https://pubmed.ncbi.nlm.nih.gov/9482480

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