Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Patrick J. Sabourin"'
Autor:
Katherine A. B. Knostman, Brian M. Roche, Edward J. Wakayama, Michael A. Hawk, Zhenxu J. Ma, Kim Henderson, Carol L. Sabourin, Patrick J. Sabourin, Glenn D. Ritchie, Claire M. Matthews
Publikováno v:
International Journal of Toxicology. 35:604-615
The Food and Drug Administration Animal Rule requires evaluation of cardiovascular and central nervous system (CNS) effects of new therapeutics. To characterize an adult and juvenile mouse model, neurobehavioral and cardiovascular effects and patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e387d950544c382eeea952f8a0b15bf
https://doi.org/10.1177/1091581816646974
https://doi.org/10.1177/1091581816646974
Autor:
James P. Long, Katrina M. Waters, Carol L. K. Sabourin, Manjula D. Kasoji, Michael G. Katze, Gregory V. Stark, Richard L. Warren, Jeremy L. Craft, Daphne Vasconcelos, Adolfo García-Sastre, Mark S. Kotur, Randy A. Albrecht, Herbert S. Bresler, Patrick J. Sabourin
Publikováno v:
Archives of Virology. 158:1305-1322
Infection with pathogenic influenza viruses is associated with intense inflammatory disease. Here, we investigated the innate immune response in mice infected with H5N1 A/Vietnam/1203/04 and with reassortant human H1N1 A/Texas/36/91 viruses containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd08b4cac2d11d84a1970bfb4d3d080e
https://doi.org/10.1007/s00705-012-1593-3
https://doi.org/10.1007/s00705-012-1593-3
Autor:
Patrick J. Sabourin, Edgar J. Wakayama, Seth Gibbs, Kristen M. Patton, Carol L. K. Sabourin, Peter Hong, Claire M. Matthews, Christina L. Kobs
Publikováno v:
International journal of toxicology. 35(5)
Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia. A well-characterized model of oral KCN intoxication is needed to test new therapeutics under the Food and Drug Administration Animal Rule. Clinical si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516a870da8292c256dd6496db3bf4eaa
https://pubmed.ncbi.nlm.nih.gov/27170682
https://pubmed.ncbi.nlm.nih.gov/27170682
Autor:
Carole R. Baskin, Michael G. Katze, Randy A. Albrecht, Carol L. K. Sabourin, Adolfo García-Sastre, J. A. Pyles, Helle Bielefeldt-Ohmann, Terrence M. Tumpey, Patrick J. Sabourin, A.-E. Tolnay, James P. Long
Publikováno v:
Archives of Virology
The mechanisms responsible for virulence of influenza viruses in humans remain poorly understood. A prevailing hypothesis is that the highly pathogenic virus isolates cause a severe cytokinemia precipitating acute respiratory distress syndrome and mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0799341e752c7e8119c3950fbf877d5c
Autor:
Sean Proll, John A. Pyles, Airn-E. Tolnay, Terrence M. Tumpey, Helle Bielefeldt-Ohmann, Carole R. Baskin, Carol L. K. Sabourin, Kaja Murali-Krishna, Michael G. Katze, James P. Long, Randy A. Albrecht, Jamie L. Fornek, Edward A. Clark, Adolfo García-Sastre, Patrick J. Sabourin, Lauri D. Aicher, Pam H. Olson, Elizabeth Rosenzweig, Mark S. Kotur, Robert E. Palermo
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3455-3460
The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To identify crucial components of the early host response during these infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de8930262d69a23f3d4ae451c6ef008
https://doi.org/10.1073/pnas.0813234106
https://doi.org/10.1073/pnas.0813234106
Autor:
Young W. Choi, James V. Rogers, Lenore F. Giannunzio, Carol L. K. Sabourin, Patrick J. Sabourin, Emily G. Blosser, Daniel M. Bornman
Publikováno v:
Microbial Pathogenesis. 43:67-77
Yersinia pestis is one of the most threatening biological agents due to the associated high mortality and history of plague pandemics. Identifying molecular players in the host response to infection may enable the development of medical countermeasur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699eac61cb437e8c6128040c4d954091
https://doi.org/10.1016/j.micpath.2007.04.001
https://doi.org/10.1016/j.micpath.2007.04.001
Autor:
Janice E. Chambers, Michael R. Franklin, M. Elizabeth Hodgson, R. Michael Roe, Carol L. K. Sabourin, Ronald L. Baynes, Ernest Hodgson, Marcé D. Lorenzen, Loganathan Ponnusamy, Hari K. Bhat, Lauren M. Aleksunes, Sharon A. Meyer, Richard B. Mailman, John Seubert, Patrick J. Sabourin, David A. Lawrence, Andrew D. Wallace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5691ed9dcb020c4ab3a4e3ff2ef1b210
https://doi.org/10.1016/b978-0-12-420169-9.00032-1
https://doi.org/10.1016/b978-0-12-420169-9.00032-1
Autor:
Jon A. Hotchkiss, P. Gerde, Jack R. Harkema, Patrick J. Sabourin, Rogene F. Henderson, Bruce A. Muggenburg, Mark D. Hoover
Publikováno v:
Toxicology and Applied Pharmacology. 121:319-327
Physiological models have predicted that the lipophilicity of solutes such as polycyclic aromatic hydrocarbons (PAHs) will delay clearance from the respiratory tract. This clearance consists of a delayed penetration of the mucous lining layer (MLL),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e45dd64f9ba7f5f4c0a2b0b3af8f43d
https://doi.org/10.1006/taap.1993.1160
https://doi.org/10.1006/taap.1993.1160
Autor:
Carol L. K. Sabourin, Helle Bielefeldt-Ohmann, Richard D. Smith, Marina A. Gritsenko, Randy A. Albrecht, Michael G. Katze, Jon M. Jacobs, Terrence M. Tumpey, Adolfo García-Sastre, Joseph N. Brown, Patrick J. Sabourin, Carole R. Baskin, James P. Long, Robert E. Palermo
The host proteome response and molecular mechanisms that drive disease in vivo during infection by a human isolate of the highly pathogenic avian influenza virus (HPAI) and 1918 pandemic influenza virus remain poorly understood. This study presents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb91a9610b9804b838277a47f5a31a7
https://europepmc.org/articles/PMC2977874/
https://europepmc.org/articles/PMC2977874/
Autor:
Linda S. Birnbaum, Patrick J. Sabourin, F. Thurmond, Michele A. Medinsky, Rogene F. Henderson
Publikováno v:
Fundamental and Applied Toxicology. 19:124-132
The glycol ethers methoxyethanol (ME), ethoxyethanol (EE), and butoxyethanol (BE) are widely used in industrial and house-hold products. Rodent studies indicate the ME and EE are potentially toxic compounds causing teratogenic, fetotoxic, hematotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772961cd663e0c7f5098592f7c456c4e
https://doi.org/10.1016/0272-0590(92)90036-h
https://doi.org/10.1016/0272-0590(92)90036-h