Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers

Autor: Raúl M. Pérez-García, Patrick J. Riss

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines in yields of up to 93% was devised. Mild conditions, benign reagents, short reaction times, low temperatures and a wide substrate scope cha

Externí odkaz: https://doaj.org/article/00e50080fbc04460bf2a0481d9c4fc77

First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor

Autor: Richard Fjellaksel, Ana Oteiza, Montserrat Martin-Armas, Patrick J. Riss, Ole Kristian Hjelstuen, Samuel Kuttner, Jørn H. Hansen, Rune Sundset

Publikováno v: BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)

Abstract Objectives In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain. Results We have used a simple,

Externí odkaz: https://doaj.org/article/3607d71fbd3c4182b734edd5904049fa

Recent Development of Non-Peptide GnRH Antagonists

Autor: Feng-Ling Tukun, Dag Erlend Olberg, Patrick J. Riss, Ira Haraldsen, Anita Kaass, Jo Klaveness

Publikováno v: Molecules, Vol 22, Iss 12, p 2188 (2017)

The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system. It stimulates di

Externí odkaz: https://doaj.org/article/1aeee90d3da54c5f9d7c950071210692

Training the next generation of radiopharmaceutical scientists

Autor: Marianne Patt, Yuji Kuge, Ulises Jáuregui-Haza, Zhi Yang, Jan Andersson, Ekoume Fany Pricile, Ephraim E. Parent, Ralph Santos-Oliveira, Johnny Vercouillie, Ya-Yao Huang, Joao A. Osso, Matthias M. Herth, Michelle L. James, Hank F. Kung, Eric D. Hostetler, Wolfgang Wadsak, Antony D. Gee, Rajiv Bhalla, Stephen Taylor, David W. Dick, Hua Zhu, Patrick J. Riss, Aruna Korde, Neil Vasdev, Yearn Seong Choe, Jae Min Jeong, Peter Scott, Suzanne E. Lapi

Publikováno v: Gee, A D, Andersson, J, Bhalla, R, Choe, Y S, Dick, D W, Herth, M M, Hostetler, E D, Jauregui-Haza, U J, Huang, Y-Y, James, M L, Jeong, J M, Korde, A, Kuge, Y, Kung, H F, Lapi, S E, Osso, J A, Parent, E, Patt, M, Pricile, E F, Riss, P J, Santos-Oliveira, R, Taylor, S, Vasdev, N, Vercouillie, J, Wadsak, W, Yang, Z, Zhu, H & Scott, P J H 2020, ' Training the next generation of radiopharmaceutical scientists ', Nuclear Medicine and Biology, vol. 88-89, pp. 10-13 . https://doi.org/10.1016/j.nucmedbio.2020.06.004

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3ae6d1a2d2a5c496964e068cb637a4
https://doi.org/10.1016/j.nucmedbio.2020.06.004

Evaluation of [18F]-N-Methyl lansoprazole as a Tau PET Imaging Agent in First-in-Human Studies

Autor: Waqas Rafique, Kirk A. Frey, Rodrigo O Kuljis, Vasko Kramer, Horacio Amaral, David M. Raffel, Patrick J. Riss, Robert A. Koeppe, Peter J. H. Scott, Arlette Haeger, Allen F. Brooks

Publikováno v: ACS Chemical Neuroscience. 11:427-435

Development of positron emission tomography (PET) imaging agents capable of quantifying tau aggregates in neurodegenerative disorders such as Alzheimer's disease (AD) is of enormous importance in the field of dementia research. The aim of the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2e3f38dcb6dde5fbfb416be83cc078e
https://doi.org/10.1021/acschemneuro.9b00639