Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Patrick J. Pagano"'
Autor:
Matthew T. Keeney, Eric K. Hoffman, Kyle Farmer, Christopher R. Bodle, Marco Fazzari, Alevtina Zharikov, Sandra L. Castro, Xiaoping Hu, Amanda Mortimer, Julia K. Kofler, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Edward A. Burton, Teresa G. Hastings, J. Timothy Greenamyre, Roberto Di Maio
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105754- (2022)
Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's disease (PD) pathogenesis and there is evidence that mitochondrially-generated superoxide can activate NADPH oxidase 2 (NOX2). Although NOX2 has been examined in th
Externí odkaz:
https://doaj.org/article/95c583e7c1c84f7fafa51c450059efc9
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 70 (2022)
Since their discovery in the vasculature, different NADPH oxidase (NOX) isoforms have been associated with numerous complex vascular processes such as endothelial dysfunction, vascular inflammation, arterial remodeling, and dyslipidemia. In turn, the
Externí odkaz:
https://doaj.org/article/8e5e0f73c4be4990adf8cf9a138bc2df
Autor:
Evan R. DeVallance, Christopher M. Dustin, Daniel Simoes de Jesus, Imad Al Ghouleh, John C. Sembrat, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 71 (2022)
Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, causing right ventricular
Externí odkaz:
https://doaj.org/article/635c07f3c54844fa969104d819b7bff9
Autor:
Shuai Yuan, Scott A. Hahn, Megan P. Miller, Subramaniam Sanker, Michael J. Calderon, Mara Sullivan, Atinuke M. Dosunmu-Ogunbi, Marco Fazzari, Yao Li, Michael Reynolds, Katherine C. Wood, Claudette M. St Croix, Donna Stolz, Eugenia Cifuentes-Pagano, Placido Navas, Sruti Shiva, Francisco J. Schopfer, Patrick J. Pagano, Adam C. Straub
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102166- (2021)
NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2•-. The ratio of NOX4-derived H2O2 and O2•- can be altered by coenzyme Q (CoQ) mimics. Therefore, we hypothesize that cytochr
Externí odkaz:
https://doaj.org/article/8dc1b93959bb456aae238a06ad89c79a
Autor:
Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhán Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Renã A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. McGowan, Nadiezhda Cantu-Medellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St. Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Niedernhofer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://doaj.org/article/d9a5a11c481f443f90c56186ddad5c93
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagn
Externí odkaz:
https://doaj.org/article/b5a7b83f63124d5686baf7ceded9e2df
Autor:
Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett A. Kaufman, Mark T. Gladwin, Patrick J. Pagano
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Pulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone morphogenetic protein antago
Externí odkaz:
https://doaj.org/article/03a0a00b4a084e85bcad0f2982a7abc7
Autor:
Kedar Ghimire, Yao Li, Takuto Chiba, Sohel M. Julovi, Jennifer Li, Mark A. Ross, Adam C. Straub, Philip J. O’Connell, Curzio Rüegg, Patrick J. Pagano, Jeffrey S. Isenberg, Natasha M. Rogers
Publikováno v:
Cells, Vol 9, Iss 7, p 1695 (2020)
The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A ce
Externí odkaz:
https://doaj.org/article/2d0ec60913d84b10af7b3205477de3d8
Autor:
Gábor Csányi, Patrick J. Pagano
Publikováno v:
International Journal of Hypertension, Vol 2013 (2013)
Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known. The literature describes a pathophysiological role for Nox4 in cardi
Externí odkaz:
https://doaj.org/article/f83d8b4e65c649f4b274ad26c56adc0b
Autor:
Emilie Coppin, Xinyi Zhang, Lee Ohayon, Ebin Johny, Ankush Dasari, Kang H. Zheng, Lotte Stiekema, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Srilakshmi Chaparala, Erik S. Stroes, Partha Dutta
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 43(6), 889-906. Lippincott Williams and Wilkins
Background: Peripheral ischemia caused by peripheral artery disease is associated with systemic inflammation, which may aggravate underlying comorbidities such as atherosclerosis and heart failure. However, the mechanisms of increased inflammation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafedbe5e7f8ffe27818a1ec8f60dad1
https://pure.amc.nl/en/publications/peripheral-ischemia-imprints-epigenetic-changes-in-hematopoietic-stem-cells-to-propagate-inflammation-and-atherosclerosis(7aac3283-8151-447a-94bf-f2fb553f1383).html
https://pure.amc.nl/en/publications/peripheral-ischemia-imprints-epigenetic-changes-in-hematopoietic-stem-cells-to-propagate-inflammation-and-atherosclerosis(7aac3283-8151-447a-94bf-f2fb553f1383).html
