Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Patrick J. O'Shea"'
Publikováno v:
Stem Cell Research, Vol 12, Iss 2, Pp 415-427 (2014)
Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) can differentiate into multiple lineages including osteogenic and adipogenic cells. Wnt signalling has been implicated in controlling BMSC fate, but the mecha
Externí odkaz:
https://doaj.org/article/2e1c645f4fd642019f5c12c2fc2fd68e
Autor:
Ahluwalia, Vineeth Tatineni, Patrick J. O’Shea, Shreya Saxena, Atulya A. Khosla, Ahmad Ozair, Rupesh R. Kotecha, Xuefei Jia, Yasmeen Rauf, Erin S. Murphy, Samuel T. Chao, John H. Suh, David M. Peereboom, Manmeet S.
Publikováno v:
Cancers; Volume 15; Issue 11; Pages: 3015
Introduction: Traditionally, brain metastases have been treated with stereotactic radiosurgery (SRS), whole-brain radiation (WBRT), and/or surgical resection. Non-small cell lung cancers (NSCLC), over half of which carry EGFR mutations, are the leadi
Autor:
Jenna Bradley, Mike Firth, Jian-Ping Yang, James Pilling, Jonathan D. Chesnut, Jan Wildenhain, David R. Piper, Mathew Leveridge, Patrick J. O'Shea, Chetana M. Revankar, Beverley Isherwood
Publikováno v:
SLAS Discovery. 25:618-633
CRISPR/Cas9 is increasingly being used as a tool to prosecute functional genomic screens. However, it is not yet possible to apply the approach at scale across a full breadth of cell types and endpoints. In order to address this, we developed a novel
Autor:
Mike Firth, Maria Luisa Guerriero, Samantha Peel, Adam Corrigan, Douglas Ross-Thriepland, Patrick J. O'Shea, Aurélie Bornot
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(6)
Genome-wide arrayed CRISPR screening is a powerful method for drug target identification as it enables exploration of the effect of individual gene perturbations using diverse highly multiplexed functional and phenotypic assays. Using high-content im
Autor:
K. Jane Escott, Patrick J. O'Shea
Publikováno v:
The Biology and Therapeutic Application of Mesenchymal Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e5b16e6ac7bac51e452e2a8254dc1d
https://doi.org/10.1002/9781118907474.ch13
https://doi.org/10.1002/9781118907474.ch13
Autor:
Chandan K. Nagaraju, Patrick J O'Shea, James Pilling, Alessandra Gambardella, Peter I. Croucher, Sindhu T. Mohanty, Michael Sullivan, Lucksy Kottam, Mounira Djerbi, Witte Koopmann, Ilaria Bellantuono
Publikováno v:
Journal of Bone and Mineral Research. 26:811-821
Small molecules are attractive therapeutics to amplify and direct differentiation of stem cells. They also can be used to understand the regulation of their fate by interfering with specific signaling pathways. Mesenchymal stem cells (MSCs) have the
Autor:
Björn Vennström, P. G. T. Howell, Graham R. Williams, S.-Y. Cheng, Alan Boyde, Patrick J. O'Shea, J. H. D. Bassett, Jacques Samarut, Olivier Chassande
Publikováno v:
Scanning. 28:57-131
Childhood hypothyroidism causes delayed endochondral ossification, impaired bone mineralization and growth retardation. In contrast, thyrotoxicosis induces accelerated growth, advanced bone age and increased mineralization, but leads to premature clo
Autor:
Graham R. Williams, Srividya Sriskantharajah, J. H. Duncan Bassett, Patrick J. O'Shea, Sheue-yann Cheng, Hao Ying
Publikováno v:
Molecular Endocrinology. 19:3045-3059
Thyroid hormone (T(3)) regulates bone turnover and mineralization in adults and is essential for skeletal development. Surprisingly, we identified a phenotype of skeletal thyrotoxicosis in T(3) receptor beta(PV) (TRbeta(PV)) mice in which a targeted
Autor:
Patrick J. O'Shea, David Stevens, Graham R. Williams, D.J Jackson, Clare B. Harvey, Allan J. Williams
Publikováno v:
Molecular and Cellular Endocrinology. 213:87-97
Thyroid hormones regulate gene expression to influence the development and metabolism of many tissues including bone. The identification of genes that are regulated by thyroid hormones during skeletal development requires sensitive and quantitative t
Autor:
Clare B. Harvey, Graham R. Williams, Hideyo Suzuki, Patrick J. O'Shea, Sheue-yann Cheng, Masahiro Kaneshige, Kumiko Kaneshige
Publikováno v:
Molecular Endocrinology. 17:1410-1424
Thyroid hormone (T3) regulates bone turnover and mineralization in adults and is essential for skeletal development during childhood. Hyperthyroidism is an established risk factor for osteoporosis. Nevertheless, T3 actions in bone remain poorly under