Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Autor: Patrick J Nygren, Sohum Mehta, Devin K Schweppe, Lorene K Langeberg, Jennifer L Whiting, Chad R Weisbrod, James E Bruce, Jin Zhang, David Veesler, John D Scott

Publikováno v: eLife, Vol 6 (2017)

Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (A

Externí odkaz: https://doaj.org/article/5f4da514208a4f9884397e3ab2fb4cf5

Local protein kinase A action proceeds through intact holoenzymes

Autor: Patrick A. Eyers, I. Strashnov, Jessica L. Esseltine, Claire E. Eyers, David Veesler, F. Donelson Smith, Matthias Vonderach, Lorene K. Langeberg, Dominic P. Byrne, Patrick J. Nygren, John D. Scott

Publikováno v: Smith, F D, Esseltine, J L, Nygren, P J, Veesler, D, Byrne, D P, Vonderach, M, Strashnov, I, Eyers, C E, Eyers, P A, Langeberg, L K & Scott, J D 2017, ' Local protein kinase A action proceeds through intact holoenzymes ', Science, vol. 356, no. 6344, pp. 1288-1293 . https://doi.org/10.1126/science.aaj1669
Science

PKA-activation mechanism revised Many hormone receptors stimulate production of cyclic AMP (adenosine monophosphate), which activates PKA (protein kinase A). The textbook view suggests that activation releases the catalytic subunit of the enzyme from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfb158fd57734ea083605cedee37da9
https://doi.org/10.1126/science.aaj1669

AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

Autor: Simon A. Hinke, Dinesh Hirenallur-Shanthappa, Patrick J. Nygren, Manuel F. Navedo, Mark L. Dell'Acqua, Madeline Nieves-Cintrón, John D. Scott, Luis Fernando Santana, Lorene K. Langeberg

Publikováno v: Cellular signalling, vol 28, iss 7

The Ca(2+)-responsive phosphatase calcineurin/protein phosphatase 2B dephosphorylates the transcription factor NFATc3. In the myocardium activation of NFATc3 down-regulates the expression of voltage-gated K(+) (Kv) channels after myocardial infarctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688a71f9e21d6431155f43438bce50f8
https://doi.org/10.1016/j.cellsig.2015.12.015

Author response: Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Autor: Sohum Mehta, Chad R. Weisbrod, Jin Zhang, John D. Scott, Jennifer L. Whiting, Lorene K. Langeberg, Patrick J. Nygren, David Veesler, Devin K. Schweppe, James E. Bruce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f821f55215387d6a0871840d36f58ab
https://doi.org/10.7554/elife.30872.022

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex

Autor: Chad R. Weisbrod, Matthew G. Gold, John D. Scott, Patrick J. Nygren, David Barford, Florian Stengel, Carol V. Robinson, James E. Bruce

Publikováno v: Proceedings of the National Academy of Sciences; Vol 108
Proceedings of the National Academy of Sciences

A-kinase anchoring protein 79 (AKAP79) is a human anchoring protein that organizes cAMP-dependent protein kinase (PKA), Ca 2+ /calmodulin (CaM)-dependent protein phosphatase (PP2B), and protein kinase C (PKC) for phosphoregulation of synaptic signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a492a9c755aa5295a13ec7967933cd
https://doi.org/10.1073/pnas.1014400108