Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Patrick J. Middleton"'
Autor:
Diana F. Thomas, Bharati Pai, Susanna Wu-Pong, Robert Tam, Josie Bard, Charmaine Lim, Amy Chan, Tatjana Milovanovic, Patrick J. Middleton
Publikováno v:
Antisense and Nucleic Acid Drug Development. 9:289-300
We previously showed that inhibition of the expression of CD28 (an essential immune receptor on T cells) mediated by a phosphorothioate (PS)-modified aptameric oligodeoxynucleotide (ODN) sequence, GR1, resulted in reduced T cell responses in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570d8fec6b2530842b65224140d96ae4
https://doi.org/10.1089/oli.1.1999.9.289
https://doi.org/10.1089/oli.1.1999.9.289
Autor:
Guangyi Wang, Patrick J. Middleton
Publikováno v:
Nucleosides and Nucleotides. 17:1033-1051
Thymidine was converted to its 5′-epoxy derivative, which was reacted with nucleophiles to give 5′-C-aminomethyl-, 5′-C-bromomethyl-, 5′-C-cyanomethyl, and 5′-C-methoxymethylthymidine derivatives with defined stereochemistry. 5′-C-ally-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e61a0963c6ad3ebbca0090b1101dbd
https://doi.org/10.1080/07328319808004219
https://doi.org/10.1080/07328319808004219
Publikováno v:
Nucleosides and Nucleotides. 16:445-454
3′-C-Aminomethyl- and 3′-C-methylthymidine were synthesized and incorporated into oligodeoxynucleotides. Hybridization and enzyme stability of the modified oligonucleotides containing the 3′-C-branched thymidines are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f193ccfcf09baead3a8e64a9f6fce8a3
https://doi.org/10.1080/07328319708001361
https://doi.org/10.1080/07328319708001361
Publikováno v:
Tetrahedron Letters. 38:2393-2396
5′-C-Hydroxymethyl-, 5′-C-hydroxyethyl, and 5′-C-hydroxypropylthymidine derivatives were prepared through four synthetic routes, which constitute an approach to introduce hydroxyalkyl of different lengths at C5′ of thymidine. 5′-C-hydroxyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5bf6e915ab197d9fac805a0c673f25
https://doi.org/10.1016/s0040-4039(97)00386-9
https://doi.org/10.1016/s0040-4039(97)00386-9
Autor:
Guangyi Wang, Patrick J. Middleton
Publikováno v:
Tetrahedron Letters. 37:2739-2742
Thymidine was converted to its 5′(S)-epoxy derivative, which reacted with nucleophiles to give 5′(S)-C-aminomethyl-, 5′(S)-C-azidomethyl-, 5′(S)-C-cyanomethyl-, and 5′(S)-C-methoxymethyl-thymidine with defined stereochemistry. 5′-C-Allyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1397d1c6b84aeb55e9b8b2be9047072f
https://doi.org/10.1016/0040-4039(96)00418-2
https://doi.org/10.1016/0040-4039(96)00418-2
Publikováno v:
ChemInform. 28
5′-C-Hydroxymethyl-, 5′-C-hydroxyethyl, and 5′-C-hydroxypropylthymidine derivatives were prepared through four synthetic routes, which constitute an approach to introduce hydroxyalkyl of different lengths at C5′ of thymidine. 5′-C-hydroxyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15c1b21c17fd6ab942df82f7f943d7a8
https://doi.org/10.1002/chin.199729220
https://doi.org/10.1002/chin.199729220
Autor:
Patrick J. Middleton, Guangyi Wang
Publikováno v:
ChemInform. 29
Thymidine was converted to its 5′-epoxy derivative, which was reacted with nucleophiles to give 5′-C-aminomethyl-, 5′-C-bromomethyl-, 5′-C-cyanomethyl, and 5′-C-methoxymethylthymidine derivatives with defined stereochemistry. 5′-C-ally-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d71a3ea9dfed52004f8a7408ada3180
https://doi.org/10.1002/chin.199837255
https://doi.org/10.1002/chin.199837255
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(6)
We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61285abe31917518b3583ee339ca7c71
https://pubmed.ncbi.nlm.nih.gov/10206555
https://pubmed.ncbi.nlm.nih.gov/10206555