Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Patrick J. Lupardus"'
Publikováno v:
eLife, Vol 7 (2018)
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present tw
Externí odkaz:
https://doaj.org/article/1250dbe478004f90b78369520c4b99fe
Autor:
Martin Oft, Navneet Ratti, Sandro Vivona, Jan Emmerich, Romina Riener, Ievgen O. Koliesnik, Scott McCauley, Michele Bauer, Marie Semana, Deepti Rokkam, Bhargavi Jayaraman, Rene de Waal Malefyt, Paul-Joseph Aspuria, Michael Totagrande, Anita Mehta-Damani, Patrick J. Lupardus, Rob A. Kastelein
Publikováno v:
Cancer Research. 83:1801-1801
High-dose Interleukin-2 (IL-2) monotherapy induces complete responses in cancer patients but its use is limited by acute vascular toxicities including capillary leak syndrome and severe hypotension 1,2. IL-2 activates lymphocytes and NK-cells through
Abstract 1833: Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity
Autor:
Ievgen Koliesnik, Jan Emmerich, Kim Q. Tran, Michele Bauer, Michael Totagrande, Bhargavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Deepti Rokkam, Rene de Waal Malefyt, Luis Zuniga, Heiko Greb, Navneet Ratti, Sandro Vivona, Martin Oft, Patrick J. Lupardus, Robert A. Kastelein
Publikováno v:
Cancer Research. 83:1833-1833
Here we report on a novel human IL-12 partial agonist (hIL-12v) that has diminished binding to IL-12Rb1. IL-12v is designed to more selectively engage antigen activated T-cells, which strongly upregulate IL-12Rb1 upon activation, and to reduce stimul
Autor:
Conor Hayes, Marine C.C. Raman, C.H. Coles, Stephen Harper, Linda Hibbert, Patrick J. Lupardus, David K. Cole, Angharad Lloyd, Catriona McMurran, Miriam Hock
Publikováno v:
The Journal of Biological Chemistry
T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for immunosurveillance and disease control. This interaction is generally stabilized by interacti
Autor:
Paul-Joseph Aspuria, Sandro Vivona, Michele Bauer, Marie Semana, Navneet Ratti, Scott McCauley, Romina Riener, Rene de Waal Malefyt, Deepti Rokkam, Jan Emmerich, Rob A. Kastelein, Patrick J. Lupardus, Martin Oft
Publikováno v:
Science Translational Medicine. 13
Chimeric antigen receptor (CAR) T cells induce durable responses in patients with refractory hematological tumors. However, low CAR T cell activity, poor engraftment, or short in-patient persistence can lead to tumor progression or relapse. Furthermo
Autor:
Jawahar Sudhamsu, Kelly M. Loyet, Patrick J. Lupardus, Jianping Yin, Yan Wu, Jianhuan Zhang, Wei-Ching Liang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Antibody function is typically entirely dictated by the Complementarity Determining Regions (CDRs) that directly bind to the antigen, while the framework region acts as a scaffold for the CDRs and maintains overall structure of the variable domain. W
Autor:
Zhaowu Xu, Charles Eigenbrot, Patrick J. Lupardus, Rina Fong, Jing Wang, Huifen Chen, Gauri Deshmukh, Gregory Hamilton, Snahel Patel, Haowei Wang, Domagoj Vucic, Yunliang Zhu, Pawan Bir Kohli, Adam R. Johnson, Bianca M. Liederer, Sreemathy Ramaswamy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1497-1501
Receptor-interacting protein kinase 1 (RIPK1), a key component of the cellular necroptosis pathway, has gained recognition as an important therapeutic target. Pharmacologic inhibition or genetic inactivation of RIPK1 has shown promise in animal model
Autor:
Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1522-1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor
Autor:
Patrick Caplazi, P. Bir Kohli, Joshua D. Webster, M. van Lookeren Campagne, Allie Maltzman, Gregory Hamilton, Wyne P. Lee, Evgeny Varfolomeev, Rina Fong, Brent S. McKenzie, Melissa R. Junttila, Swathi Sujatha-Bhaskar, Juan Zhang, Katherine E. Wickliffe, Patrick J. Lupardus, Debra L. Dugger, Domagoj Vucic, Snahel Patel, J.H. Cheng, Bianca M. Liederer, Kim Newton, Youngsu Kwon, Sreemathy Ramaswamy, Adam R. Johnson, Gauri Deshmukh
Publikováno v:
Cell Death and Differentiation
The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. H
Autor:
Christina Kochel, Meng Sun, Navneet Ratti, Sandro Vivona, Mahalaksmi Ramadass, Marie Semana, Michele Bauer, Mohammed Ali, Jan Emmerich, Rob Kastelein, Patrick J. Lupardus, Paul-Joseph Aspuria, Martin Oft
Publikováno v:
Cancer Research. 82:586-586
Multiple adoptive T-cell therapy modalities (ACT) have delivered promising clinical responses in cancer patients. However, challenges including poor T cell effector function, lack of proliferation, and limited persistence have prevented ACTs from rea