Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Patrick J. Lennon"'
Autor:
Sheri L. Bonar, Adam Libby, Yao Min, Richard Weier, Michael B. Tollefson, Serge G. Wolfson, Michael Clare, Ann M. Donnelly, William E. Mcghee, Dominique Bonafoux, Patrick J. Lennon, Sumathy Mathialagan, Julia A. Guzova, Nandini Kishore, Cindy Sommers, Sharon Rouw, Lori Christine, Catherine S. Tripp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2870-2875
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752b9930690fa8fa16c025496d6ce863
https://doi.org/10.1016/j.bmcl.2005.03.090
https://doi.org/10.1016/j.bmcl.2005.03.090
Autor:
Mark G. Currie, Zhi-Qiang Wang, Heather Macarthur, Thomas P. Misko, Dennis P. Riley, Patrick J. Lennon, Daniela Salvemini
Publikováno v:
British Journal of Pharmacology. 127:685-692
The relative contributions of superoxide anion (O2−) and peroxynitrite (PN) were evaluated in the pathogenesis of intestinal microvascular damage caused by the intravenous injection of E. coli lipopolysaccharide (LPS) in rats. The superoxide dismut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c31f35bcce84118e52179dca8aeef618
https://doi.org/10.1038/sj.bjp.0702604
https://doi.org/10.1038/sj.bjp.0702604
Publikováno v:
Journal of the American Chemical Society. 119:6522-6528
Two new isomeric bis(trans-fused cyclohexano) substituted 1,4,7,10,13-pentaazacyclopentadecane ligands and their Mn(II) complexes, 3 and 4, have been synthesized, and their activity as superoxide dismutase (SOD) catalysts has been studied. Complex 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ef29779ed71bc33d44514927943e78
https://doi.org/10.1021/ja964271e
https://doi.org/10.1021/ja964271e
Autor:
Randy H. Weiss, Kirby R. Sample, William L. Neumann, Witold Szulbinski, † Chaur-Sun Ling, Patrick J. Lennon, Dennis P. Riley, Willie J. Rivers, Jeng-Jong Shieh, Karl W. Aston, Hayat Rahman, and Daryle H. Busch, Susan L. Henke
Publikováno v:
Inorganic Chemistry. 35:5213-5231
Superoxide radical anion has been demonstrated to be a mediator of many disease states, including inflammatory, autoimmune, and cancerous diseases. As a consequence, we have developed a program to design, synthesize, and test synthetic low-molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056ffc4cdfadf921ef7fe57c7355a58c
https://doi.org/10.1021/ic960262v
https://doi.org/10.1021/ic960262v
Publikováno v:
Tetrahedron Letters. 35:853-856
The synthesis of two new series of conformationally constrained polyazamacrocycles featuring polysubstitution at macrocycle ring carbons is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43696daefd46cf01dad8cf85c1d4041c
https://doi.org/10.1016/s0040-4039(00)75981-8
https://doi.org/10.1016/s0040-4039(00)75981-8
Autor:
Barry L. Parnas, Randy H. Weiss, Richard W. Gross, Stanley L. Hazen, Daniel P. Getman, Karl W. Aston, Patrick J. Lennon, Lori A. Zupan
Publikováno v:
Journal of Medicinal Chemistry. 36:95-100
Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic mediators of membrane dysfunction during myocardial ischemia (Hazen, S. L.; et al. J. Biol. Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397d9026a25039dc79e818e404d01aa
https://doi.org/10.1021/jm00053a012
https://doi.org/10.1021/jm00053a012
Autor:
Matthew T. Reding, Horng-Chih Huang, Sumathy Mathialagan, Neetu Venkatraman, Jin Xie, Xiong Li, Sarah J. Brustkern, Gennadiy Poda, Shaun R. Selness, Serge G. Wolfson, Cynthia D. Sommers, Natalie X. Chen, Lori Christine, Yiding Hu, Nandini Kishore, Ravi G. Kurumbail, Sheri L. Bonar, Richard F. Heier, Patrick J. Lennon
Publikováno v:
Bioorganicmedicinal chemistry. 19(3)
Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify a novel series of aminopyridinecarboxamide-based IKK-2 inhibitors, which display low nanom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f208e64a4c631435dcaa7ad7dfeaa04
https://pubmed.ncbi.nlm.nih.gov/21236687
https://pubmed.ncbi.nlm.nih.gov/21236687
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cb057463faa2c2b35d5618ec72855a
https://doi.org/10.1002/chin.199425160
https://doi.org/10.1002/chin.199425160
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c55085ef700a7f7c0192790ba135ef
https://doi.org/10.1002/chin.199936200
https://doi.org/10.1002/chin.199936200
Autor:
Sharon Rouw, Adam Libby, Michael Clare, Horng-Chih Huang, Cynthia D. Sommers, Julia A. Guzova, Nandidni N. Kishore, Richard Weier, Sheri L. Bonar, Sumathy Mathialagan, Lori J. Vanella, Dominique Bonafoux, Jeanette L. Glaenzer, Koszyk Francis, Ann M. Donnelly, He Huang, David S. Oburn, Patrick J. Lennon, Catherine S. Tripp, Serge G. Wolfson
Publikováno v:
Bioorganicmedicinal chemistry. 18(1)
Series of aminopyridinecarboxamide-based inhibitors were synthesized and tested against human recombinant IKK-2 and in IL-1beta stimulated synovial fibroblasts. The 2-amino-5-chloropyridine-4-carboxamides were identified as the most potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76055db0ef28806da346227b07a394
https://pubmed.ncbi.nlm.nih.gov/19914076
https://pubmed.ncbi.nlm.nih.gov/19914076