Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Patrick J. Kerzic"'
Autor:
Richard D. Irons, Patrick J. Kerzic
Publikováno v:
Environmental toxicology and pharmacology. 55
Results of laboratory studies and investigations of occupationally exposed healthy individuals have been used to develop a mode of action for benzene-induced leukemia that mirrors disease following treatment with chemotherapeutic agents. Recently we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e16c269300ae706a5ddde52b42e21
https://pubmed.ncbi.nlm.nih.gov/28926803
https://pubmed.ncbi.nlm.nih.gov/28926803
Publikováno v:
Genes, Chromosomes and Cancer. 52:887-894
Benzene (Bz) is widely regarded as a prototype environmental leukemogen and individuals chronically exposed are at risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is widely assumed that initiation and pathogenesis of AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1840b4219461af30dd8053e26ac894
https://doi.org/10.1002/gcc.22084
https://doi.org/10.1002/gcc.22084
Publikováno v:
Cell Biology and Toxicology. 22:229-241
The transcriptional regulatory factor PU.1 is important for the regulation of a diverse group of hematopoietic and myeloid genes. Posttranslational phosphorylation of PU.1 has been demonstrated in the regulation of a variety of promoters in normal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca5e98c12b2f7b65488eb6827a9628a
https://doi.org/10.1007/s10565-006-0128-7
https://doi.org/10.1007/s10565-006-0128-7
Autor:
Sherilyn A. Gross, Anh T. Le, Ling Lv, John Ryder, Xibiao Ye, Thomas W. Armstrong, Wei-Min Ni, Lizhaung Miao, Hua Fu, Patrick J. Kerzic, Yimei Zhou, Richard D. Irons, Liming Bao, Xiaoqin Wang
Publikováno v:
Leukemia Research. 29:1371-1380
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workers exposed to high concentrations of benzene. Distinguishin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9465eec0f3ba69b20086eb8d3900bddf
https://doi.org/10.1016/j.leukres.2005.08.019
https://doi.org/10.1016/j.leukres.2005.08.019
Publikováno v:
Cancer Chemotherapy and Pharmacology. 56:248-254
Paclitaxel (Taxol) is an effective agent against a broad range of human cancers. Studies on the metabolism and disposition of paclitaxel have shown that it is primarily eliminated via hepatic metabolism by P450 enzymes (2C8 and 3A4) to essentially in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6383b150bc1e7fa63985c8445df28f33
https://doi.org/10.1007/s00280-004-0988-6
https://doi.org/10.1007/s00280-004-0988-6
Autor:
Anh T. Le, Richard D. Irons, Patrick J. Kerzic, Jia Hua Zheng, Sherilyn A. Gross, David W. Pyatt
Publikováno v:
Leukemia. 18:1296-1304
Human leukemogens, including alkylating chemotherapeutic agents and benzene, enhance granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent proliferation of human CD34+ bone marrow (BM) cells. The extracellular signal-regulated kinase (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e6b8593f83d5bed49056856894c592
https://doi.org/10.1038/sj.leu.2403389
https://doi.org/10.1038/sj.leu.2403389
Autor:
Sherilyn A. Gross, Anh T. Le, Patrick J. Kerzic, Jia Hua Zheng, Richard D. Irons, David W. Pyatt
Publikováno v:
Toxicology. 187:127-137
Suppression of hematopoiesis is an important mechanism governing blood cell formation. Factors such as tumor necrosis factor alpha (TNF-alpha) inhibit proliferation and colony-forming activity of bone marrow cells and activate nuclear factor kappa B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de3e395e29ce1194fab6e428220191b
https://doi.org/10.1016/s0300-483x(03)00064-7
https://doi.org/10.1016/s0300-483x(03)00064-7
Autor:
Richard D, Irons, Patrick J, Kerzic
Publikováno v:
Annals of the New York Academy of Sciences. 1310
Hematopoiesis in health and disease results from complex interactions between primitive hematopoietic stem cells (HSCs) and the extrinsic influences of other cells in the bone marrow (BM) niche. Advances in stem cell biology, molecular genetics, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abee48f1bff3e23bc96817ddaa517477
https://pubmed.ncbi.nlm.nih.gov/24611724
https://pubmed.ncbi.nlm.nih.gov/24611724
Publikováno v:
Journal of Biological Chemistry. 276:28954-28960
The hematopoietic cells from patients with Bcr-Abl-positive chronic myelogenous leukemia exhibit multiple abnormalities of cytoskeletal function. The molecular events leading to these abnormalities are not fully understood. Previously we showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bf7234e14c0e35dfe6a15372503e2f
https://doi.org/10.1074/jbc.m101170200
https://doi.org/10.1074/jbc.m101170200
Publikováno v:
Experimental Hematology. 28:1181-1186
Objective The use of allogeneic cord blood (CB) products as a source of cellular support for patients receiving high-dose chemotherapy has been limited primarily to smaller children due to the low numbers of cells in a CB unit. Ex vivo expansion of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b78fd12853f64c32cfee9f1c01e1494
https://doi.org/10.1016/s0301-472x(00)00520-8
https://doi.org/10.1016/s0301-472x(00)00520-8