Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patrick J. Kearney"'
Autor:
Patrick J. Kearney, Yuanxi Zhang, Marianna Liang, Yanglan Tan, Elizabeth Kahuno, Tucker L. Conklin, Rita R. Fagan, Rebecca G. Pavchinskiy, Scott A. Shaffer, Zhenyu Yue, Haley E. Melikian
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc). Rit2 is a reported PD risk allele, and recent single cell t
Externí odkaz:
https://doaj.org/article/6c37481e4ef04753b7e5db70242f8c05
Autor:
Patrick J. Kearney, Yuanxi Zhang, Yanglan Tan, Elizabeth Kahuno, Tucker L. Conklin, Rita R. Fagan, Rebecca G. Pavchinskiy, Scott A. Shafer, Zhenyu Yue, Haley E. Melikian
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea91e01ad54d1cad7e4e1d1b47e1a3f
https://doi.org/10.1101/2023.04.26.538430
https://doi.org/10.1101/2023.04.26.538430
Autor:
Patrick J. Kearney, Nicholas C. Bolden, Elizabeth Kahuno, Tucker L. Conklin, Gilles E. Martin, Gert Lubec, Haley E. Melikian
Publikováno v:
Journal of Biological Chemistry. 299:102900
Autor:
Harald H. Sitte, Nicholas C Bolden, Dino Luethi, Haley E. Melikian, Rita R. Fagan, Patrick J. Kearney, Patrick Emery
Publikováno v:
Mol Psychiatry
Dopamine (DA) is required for movement, sleep, and reward, and DA signaling is tightly controlled by the presynaptic DA transporter (DAT). Therapeutic and addictive psychostimulants, including methylphenidate (Ritalin; MPH), cocaine, and amphetamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1c0a836622f28f7f2e1f4001e0a4de
https://europepmc.org/articles/PMC8881384/
https://europepmc.org/articles/PMC8881384/
Autor:
Patrick J. Kearney, Elizabeth Kahuno, Tucker L. Conklin, Gilles E. Martin, Gert Lubec, Haley E. Melikian
Extracellular dopamine (DA) levels are constrained by the presynaptic DA transporter (DAT), a major psychostimulant target. Despite its necessity for DA neurotransmission, DAT regulation in situ is poorly understood, and it is unknown whether regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098af9b4986b0b9afe80ec976a49558a
https://doi.org/10.1101/2021.06.04.447129
https://doi.org/10.1101/2021.06.04.447129
Autor:
Rita R. Fagan, Patrick Emery, Harald H. Sitte, Patrick J. Kearney, Haley E. Melikian, Nicholas C Bolden, Dino Luethi
Dopamine (DA) is required for movement, sleep, and reward, and DA signaling is tightly controlled by the presynaptic DA transporter (DAT). Therapeutic and addictive psychostimulants, including methylphenidate (Ritalin; MPH), cocaine, and amphetamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbf136a40399b74b38538a7af0b5fe9e
https://doi.org/10.1101/2021.02.18.431857
https://doi.org/10.1101/2021.02.18.431857
Publikováno v:
Neurochem Res
Dopamine (DA) is critical for motivation, reward, movement initiation, and learning. Mechanisms that control DA signaling have a profound impact on these important behaviors, and additionally play a role in DA-related neuropathologies. The presynapti
Autor:
Rita R. Fagan, Brian Alejandro, Haley E. Melikian, Harald H. Sitte, Carolyn G. Sweeney, Klaus Schicker, Florianne E. Schoot Uiterkamp, Patrick J. Kearney, Dino Luethi, Lauren C. O’Connor
Publikováno v:
J Biol Chem
Following its evoked release, DA signaling is rapidly terminated by presynaptic reuptake, mediated by the cocaine-sensitive DAT. DAT surface availability is dynamically regulated by endocytic trafficking, and direct PKC activation acutely diminishes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561a7b310e384723d5dfbc0116d911eb
https://doi.org/10.1101/712448
https://doi.org/10.1101/712448
Autor:
Haley E. Melikian, Rita R. Fagan, Andrew R. Tapper, Iris V. Rivera, Jun Xie, Nicholas C Bolden, Patrick J. Kearney, Jenya Kolpakova, Guangping Gao, Gilles E. Martin, Rubing Zhao-Shea, Carolyn G. Sweeney, Lindsey A. Smith
Publikováno v:
Neuropsychopharmacology
Dopamine (DA) signaling is critical for movement, motivation, and addictive behavior. The neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA transporter (DAT), and is implicated in several DA-related neuropsychiatric di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021ff3a3553e1030be4920062c655cf7
https://europepmc.org/articles/PMC6901441/
https://europepmc.org/articles/PMC6901441/
Autor:
Haley E. Melikian, Patrick J. Kearney
Publikováno v:
The FASEB Journal. 32