Výsledky vyhledávání - "Patrick J. Heizer"

Akademický článek

AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion

Autor: Travis B. McMurphy, Andrew Park, Patrick J. Heizer, Crystal Bottenfield, James H. Kurasawa, Yasuhiro Ikeda, Michael R. Doran

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Abstract Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver. Tissue-targeted AAV vectors allow transduction of non-hepatic cells, but this nec

Externí odkaz: https://doaj.org/article/bd8a1870b4b9408faa7c7dc829f28550

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Akademický článek

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

Autor: Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong

Publikováno v: Journal of Lipid Research, Vol 61, Iss 3, Pp 413-421 (2020)

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity

Externí odkaz: https://doaj.org/article/13a63de43af34811a3f699cc04d6c57d

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Akademický článek

Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome

Autor: Paul H. Kim, Natalie Y. Chen, Patrick J. Heizer, Yiping Tu, Thomas A. Weston, Jared L.-C. Fong, Navjot Kaur Gill, Amy C. Rowat, Stephen G. Young, Loren G. Fong

Publikováno v: JCI Insight, Vol 6, Iss 16 (2021)

The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane

Externí odkaz: https://doaj.org/article/782e92b7c80f4e82b3a9551cf8e5b14f

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Akademický článek

An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]

Autor: Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young

Publikováno v: Journal of Lipid Research, Vol 60, Iss 4, Pp 869-879 (2019)

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within t

Externí odkaz: https://doaj.org/article/24c19b72c23b4571b22124accec34bdf

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Akademický článek

Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

Autor: Mikael Larsson, Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Rosemary L. Walzem, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Publikováno v: Journal of Lipid Research, Vol 59, Iss 4, Pp 706-713 (2018)

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1−/− mice, LPL remains stranded i

Externí odkaz: https://doaj.org/article/569656b46a0e4a599c457cb73d1d2ee4

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Akademický článek

Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL[S]

Autor: Mikael Larsson, Christopher M. Allan, Rachel S. Jung, Patrick J. Heizer, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Publikováno v: Journal of Lipid Research, Vol 58, Iss 9, Pp 1893-1902 (2017)

ApoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view is based largely on studies of free LPL. We now recognize that intravascular LPL is neither free nor loosely bo

Externí odkaz: https://doaj.org/article/da10f122d15a40adafea921b2e4f8132

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Akademický článek

Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

Autor: Christopher M. Allan, Cris J. Jung, Mikael Larsson, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Tiffany Ly P. Dang, Rachel S. Jung, Anne P. Beigneux, Pieter J. de Jong, Loren G. Fong, Stephen G. Young

Publikováno v: Journal of Lipid Research, Vol 58, Iss 7, Pp 1453-1461 (2017)

Mutation of conserved cysteines in proteins of the Ly6 family cause human disease—chylomicronemia in the case of glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1) and paroxysmal nocturnal hemoglobinuria in the case of CD59. A mu

Externí odkaz: https://doaj.org/article/a2e86bfa1c6e411aac0c3ca83c2b4f34

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Akademický článek

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

Autor: Xuchen Hu, Thomas A Weston, Cuiwen He, Rachel S Jung, Patrick J Heizer, Brian D Young, Yiping Tu, Peter Tontonoz, James A Wohlschlegel, Haibo Jiang, Stephen G Young, Loren G Fong

Publikováno v: eLife, Vol 8 (2019)

Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction

Externí odkaz: https://doaj.org/article/c8058d365a7d44e2aede24f03b4dacae

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