Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Patrick J. Drew"'
Autor:
Hannah C. Bennett, Qingguang Zhang, Yuan-ting Wu, Steffy B. Manjila, Uree Chon, Donghui Shin, Daniel J. Vanselow, Hyun-Jae Pi, Patrick J. Drew, Yongsoo Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Aging is frequently associated with compromised cerebrovasculature and pericytes. However, we do not know how normal aging differentially impacts vascular structure and function in different brain areas. Here we utilize mesoscale microscopy
Externí odkaz:
https://doaj.org/article/109877cae2124134aef4a4db00150a19
Autor:
Haoyang Chen, Shubham Mirg, Prameth Gaddale, Sumit Agrawal, Menghan Li, Van Nguyen, Tianbao Xu, Qiong Li, Jinyun Liu, Wenyu Tu, Xiao Liu, Patrick J. Drew, Nanyin Zhang, Bruce J. Gluckman, Sri‐Rajasekhar Kothapalli
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Studying brain‐wide hemodynamic responses to different stimuli at high spatiotemporal resolutions can help gain new insights into the mechanisms of neuro‐ diseases and ‐disorders. Nonetheless, this task is challenging, primarily due to
Externí odkaz:
https://doaj.org/article/224d51b07cc94d758feddd8dc9824bf8
Autor:
Kyle W. Gheres, Hayreddin S. Ünsal, Xu Han, Qingguang Zhang, Kevin L. Turner, Nanyin Zhang, Patrick J. Drew
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract In the adult sensory cortex, increases in neural activity elicited by sensory stimulation usually drive vasodilation mediated by neurovascular coupling. However, whether neurovascular coupling is the same in neonatal animals as adults is con
Externí odkaz:
https://doaj.org/article/208c7d5adcdb42ec909dfc8de9b45f87
Autor:
Dakota F. Brockway, Keith R. Griffith, Chloe M. Aloimonos, Thomas T. Clarity, J. Brody Moyer, Grace C. Smith, Nigel C. Dao, Md Shakhawat Hossain, Patrick J. Drew, Joshua A. Gordon, David A. Kupferschmidt, Nicole A. Crowley
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112976- (2023)
Summary: We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex in mice. We performed slice electrophysiology in pyramidal and GABAergic neurons to characterize the pharmacological mechanism of SST signaling and
Externí odkaz:
https://doaj.org/article/6d6c0587838643a4b9fa5f7bc88a9bac
Autor:
Qingqing Zhang, Samuel R. Cramer, Kevin L. Turner, Thomas Neuberger, Patrick J. Drew, Nanyin Zhang
Publikováno v:
NeuroImage, Vol 268, Iss , Pp 119887- (2023)
Visual stimulation-evoked blood-oxygen-level dependent (BOLD) responses can exhibit more complex temporal dynamics than a simple monophasic response. For instance, BOLD responses sometimes include a phase of positive response followed by a phase of p
Externí odkaz:
https://doaj.org/article/62691cc27aff4339860b3fefa994de18
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-24 (2022)
Abstract The movement of fluid into, through, and out of the brain plays an important role in clearing metabolic waste. However, there is controversy regarding the mechanisms driving fluid movement in the fluid-filled paravascular spaces (PVS), and w
Externí odkaz:
https://doaj.org/article/e09f79d5ea46463e81bffb7208f8cae8
Autor:
Ravi Teja Kedarasetti, Kevin L. Turner, Christina Echagarruga, Bruce J. Gluckman, Patrick J. Drew, Francesco Costanzo
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-25 (2020)
Abstract The brain lacks a conventional lymphatic system to remove metabolic waste. It has been proposed that directional fluid movement through the arteriolar paravascular space (PVS) promotes metabolite clearance. We performed simulations to examin
Externí odkaz:
https://doaj.org/article/a479207e43ba459f8ffaf11f545b6ccb
Autor:
Ali-Kemal Aydin, William D. Haselden, Yannick Goulam Houssen, Christophe Pouzat, Ravi L. Rungta, Charlie Demené, Mickael Tanter, Patrick J. Drew, Serge Charpak, Davide Boido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Neurovascular coupling refers to changes in cerebral blood flow in response to neuronal stimulation, but to what extent this change can report neuronal activation is not known. Here the authors develop transfer functions between neural calcium signal
Externí odkaz:
https://doaj.org/article/ca77cc2297bf43129c67c4233fb0779a
Autor:
Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak, Patrick J. Drew
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Understanding mechanisms of cerebral oxygen regulation is critical for healthy brain function. Here the authors show that respiration is a key modulator of cerebral oxygenation, which will be helpful in better resolving neurally-generated functional
Externí odkaz:
https://doaj.org/article/149e92e727f04b9bbf6658abd9a6c2e9
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract The cerebral vasculature is organized to supply the brain’s metabolic needs. Sensory deprivation during the early postnatal period causes altered neural activity and lower metabolic demand. Neural activity is instructional for some aspects
Externí odkaz:
https://doaj.org/article/7d4ec6dc4e4345b1814d9d80b3d85e28