Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Patrick J. Prendergast"'
Publikováno v:
Computer Methods in Biomechanics & Biomedical Engineering – 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577379af9bd0f5ef27d5060c022661ea
https://doi.org/10.1201/9781003078289-13
https://doi.org/10.1201/9781003078289-13
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17526 (2011)
Very little is known about the regulation of morphogenesis in synovial joints. Mechanical forces generated from muscle contractions are required for normal development of several aspects of normal skeletogenesis. Here we show that biophysical stimuli
Externí odkaz:
https://doaj.org/article/39011a89ad3d4976b89b56d54627e728
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 12, p e1000250 (2008)
Although it is known that mechanical forces are needed for normal bone development, the current understanding of how biophysical stimuli are interpreted by and integrated with genetic regulatory mechanisms is limited. Mechanical forces are thought to
Externí odkaz:
https://doaj.org/article/70b062d7becf4e31b38b024bf482015b
Publikováno v:
Journal of Biomechanics. 49:458-462
Mechanical priming can be employed in tissue engineering strategies to control the fate and differentiation pattern of mesenchymal stromal cells. This is relevant to regenerative medicine whereby mechanical cues can promote the regeneration of a spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5943949c44f3174f1e7bd031e3a83fa
https://doi.org/10.1016/j.jbiomech.2015.11.053
https://doi.org/10.1016/j.jbiomech.2015.11.053
This chapter provides an overview of the main concepts in mechanobiology and touches upon the experimental models that are most frequently used to study mechanobiology on a cell and tissue level. It focuses on the use of computational techniques and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af0e293715cbbb4a111d9edaa6e98ac
https://doi.org/10.1002/9781118966174.ch20
https://doi.org/10.1002/9781118966174.ch20
Publikováno v:
Clinical Biomechanics. 27:673-679
Background Cement-in-cement revision hip arthroplasty is an increasingly popular technique to replace a loose femoral stem which retains much of the original cement mantle. However, some concern exists regarding the retention of the existing fatigued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f939f54ea5e1291089ce0bd380d5f94d
https://doi.org/10.1016/j.clinbiomech.2012.02.009
https://doi.org/10.1016/j.clinbiomech.2012.02.009
Publikováno v:
Journal of the Mechanical Behavior of Biomedical Materials. 4:1880-1887
Computational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted for an idealised or 'average' patient; we prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3745f05e85f1efe683aa328c0e39b68
https://doi.org/10.1016/j.jmbbm.2011.06.005
https://doi.org/10.1016/j.jmbbm.2011.06.005
Autor:
Alex Lennon, Nicholas Dunne, Gavin Walker, Patrick J. Prendergast, Eoin Cunningham, Caroline Newe, Fraser Buchanan
Publikováno v:
Key Engineering Materials. :861-865
The chemical compositions of calcium phosphate materials are similar to that of bone making them very attractive for use in the repair of critical size bone defects. The bioresorption of calcium phosphate occurs principally by dissolution. To determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f188db4650ead70b4f1b8f32660ecfe4
https://doi.org/10.4028/www.scientific.net/kem.493-494.861
https://doi.org/10.4028/www.scientific.net/kem.493-494.861
Autor:
Geraldine M. Kelly, Paul Weafer, Suzanne P. Jarvis, Jason I. Kilpatrick, Maarten H. van Es, Patrick J. Prendergast
Publikováno v:
Journal of Biomechanics. 44:1484-1490
The mechanical properties of cells are reported to be regulated by a range of factors including interactions with the extracellular environment and other cells, differentiation status, the onset of pathological states, as well as the intracellular fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a472cdf59bbdb966e348e95128266eb1
https://doi.org/10.1016/j.jbiomech.2011.03.011
https://doi.org/10.1016/j.jbiomech.2011.03.011
Publikováno v:
Biomechanics and modeling in mechanobiology
In genetically modified mice with abnormal skeletal muscle development, bones and joints are differentially affected by the lack of skeletal muscle. We hypothesise that unequal levels of biophysical stimuli in the developing humerus and femur can exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8f8cdd424d661217b30c86ef3c3c8a
https://doi.org/10.1007/s10237-011-0304-4
https://doi.org/10.1007/s10237-011-0304-4