Výsledky vyhledávání - "Patrick J Morris"

Akademický článek

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Autor: Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden, Thales Papagiannakopoulos

Publikováno v: eLife, Vol 6 (2017)

During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathw

Externí odkaz: https://doaj.org/article/602ecca23db94613a5c1c6970c4e76e5

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Akademický článek

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005540 (2017)

Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, a PIKfyve i

Externí odkaz: https://doaj.org/article/19a1dce2d6914c7dbc9521614d84c222

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Akademický článek

Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma

Autor: Lale Evsen, Patrick J. Morris, Craig J. Thomas, Michele Ceribelli

Publikováno v: Pharmaceuticals, Vol 16, Iss 12, p 1635 (2023)

The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in selected human cancers, leading to the aberrant activation of TEAD transcription factors. Whereas several TEAD auto-palmitoylation inhibitors are currently in

Externí odkaz: https://doaj.org/article/216c4f3e002a4488ab24c7cb21bf0bd4

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Akademický článek

Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo

Publikováno v: Microorganisms, Vol 9, Iss 3, p 566 (2021)

Outbreaks of Ebola ebolavirus (EBOV) have been associated with high morbidity and mortality. Milestones have been reached recently in the management of EBOV disease (EVD) with licensure of an EBOV vaccine and two monoclonal antibody therapies. Howeve

Externí odkaz: https://doaj.org/article/82de7543d8574e21bfe1a76eb2884bfa

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Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search

Autor: Jordi Bonaventura, Juan L. Gomez, Meghan L. Carlton, Sherry Lam, Marta Sanchez-Soto, Patrick J. Morris, Ruin Moaddel, Hye Jin Kang, Panos Zanos, Todd D. Gould, Craig J. Thomas, David R. Sibley, Carlos A. Zarate, Michael Michaelides

Publikováno v: Mol Psychiatry

The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising developments for the treatment of depression. Nevertheless, racemic ketamine and (S)-ketamine are controlled substances with known abuse potential and their use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bae031142560fd647aa3a8a7cc11f6
https://europepmc.org/articles/PMC10013843/

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Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability

Autor: Matthew A. Boehm, Patrick J. Morris, Marta Sánchez-Soto, Michael Michaelides, Juan Gómez, Jordi Bonaventura, Oscar Solis, Carlos A. Zarate, Sherry Lam, Ida Fredriksson, Craig J. Thomas, Yavin Shaham, David R. Sibley, Meghan L. Carlton

Publikováno v: Molecular Psychiatry. 26:6704-6722

Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine has known abuse liability (the tendency of a drug to be used in non-medical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fbc583e43a0be6aff65cf1cf74ca4d1
https://doi.org/10.1038/s41380-021-01093-2

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Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

Autor: Sarah M. Clark, Patrick J. Morris, Edna F. R. Pereira, Carlos A. Zarate, Jaclyn N. Highland, Todd D. Gould, Ruin Moaddel, Craig J. Thomas, Polymnia Georgiou, Lace M. Riggs, Panos Zanos

Publikováno v: Pharmacol Rev

Hydroxynorketamines (HNKs) are formed in vivo after (R,S)-ketamine (ketamine) administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl ring hydroxylation (at the 4, 5, or 6 position) and their unique stereochemistry at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c8efc07faa0a9c1ad77b60831f7f38
https://doi.org/10.1124/pharmrev.120.000149

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Hydroxynorketamine pharmacokinetics and antidepressant behavioral effects of the (2,6)- and (5R)-methyl-(2R,6R)-hydroxynorketamines

Autor: Jaclyn N. Highland, Patrick J. Morris, Kylie M. Konrath, Lace M. Riggs, Natalie R. Hagen, Panos Zanos, Chris F. Powels, Ruin Moaddel, Craig J. Thomas, Amy Q. Wang, Todd D. Gould

Publikováno v: ACS Chem Neurosci

(R,S)-ketamine is rapidly metabolized to form a range of metabolites in vivo, including 12 unique hydroxynorketamines (HNKs) that are distinguished by a cyclohexyl ring hydroxylation at the 4, 5, or 6 position. While both (2R,6R)- and (2S,6S)-HNK rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c839afe123c57e7d8f4dd0148c636fd7
https://europepmc.org/articles/PMC9926475/

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