Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Patrick J Morris"'
Autor:
Ruin Moaddel, Panos Zanos, Cristan A. Farmer, Bashkim Kadriu, Patrick J. Morris, Jacqueline Lovett, Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Peixiong Yuan, Mani Yavi, Craig J. Thomas, Lawrence T. Park, Luigi Ferrucci, Todd D. Gould, Carlos A. Zarate
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Subanesthetic-dose racemic (R,S)-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD) and has also been shown to effectively treat neuropathic pain, com
Externí odkaz:
https://doaj.org/article/a822b41b1e6245a389bcef25692869af
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1635 (2023)
The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in selected human cancers, leading to the aberrant activation of TEAD transcription factors. Whereas several TEAD auto-palmitoylation inhibitors are currently in
Externí odkaz:
https://doaj.org/article/216c4f3e002a4488ab24c7cb21bf0bd4
Autor:
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREAD
Externí odkaz:
https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
Autor:
Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, Emma Hughes, Patrick J. Morris, Jon C. Mirsalis, Linh H. Nguyen, Maria P. Arolfo, Bryan Koci, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Connie Schmaljohn, Lisa M. Johansen, Gene G. Olinger, Joshua T. Schiffer, Judith M. White
Publikováno v:
Microorganisms, Vol 9, Iss 3, p 566 (2021)
Outbreaks of Ebola ebolavirus (EBOV) have been associated with high morbidity and mortality. Milestones have been reached recently in the management of EBOV disease (EVD) with licensure of an EBOV vaccine and two monoclonal antibody therapies. Howeve
Externí odkaz:
https://doaj.org/article/82de7543d8574e21bfe1a76eb2884bfa
Autor:
Jordi Bonaventura, Sherry Lam, Meghan Carlton, Matthew Boehm, Juan L. Gomez, Oscar Solís, Marta Sánchez-Soto, Patrick J. Morris, Ida Fredriksson, Craig J. Thomas, David R. Sibley, Yavin Shaham, Carlos A. Zarate, Michael Michaelides
Publikováno v:
Molecular Psychiatry. 27:1863-1865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ced3704051c99212f936292840d81c
https://doi.org/10.1038/s41380-022-01480-3
https://doi.org/10.1038/s41380-022-01480-3
Autor:
Volkan I Sayin, Sarah E LeBoeuf, Simranjit X Singh, Shawn M Davidson, Douglas Biancur, Betul S Guzelhan, Samantha W Alvarez, Warren L Wu, Triantafyllia R Karakousi, Anastasia Maria Zavitsanou, Julian Ubriaco, Alexander Muir, Dimitris Karagiannis, Patrick J Morris, Craig J Thomas, Richard Possemato, Matthew G Vander Heiden, Thales Papagiannakopoulos
Publikováno v:
eLife, Vol 6 (2017)
During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathw
Externí odkaz:
https://doaj.org/article/602ecca23db94613a5c1c6970c4e76e5
Publikováno v:
IUCrData, Vol 2, Iss 5, p x170693 (2017)
Apilimod {systematic name: N-[(E)-(3-methylbenzylidene)amino]-6-(morpholin-4-yl)-2-[2-(pyridin-2-yl)ethoxy]pyrimidin-4-amine}, C23H26N6O2, a molecule of interest for its antiviral properties, was acquired from several different commercial vendors. An
Externí odkaz:
https://doaj.org/article/015509ad9d0a48f58e0c7220f20b7099
Autor:
Elizabeth A Nelson, Julie Dyall, Thomas Hoenen, Alyson B Barnes, Huanying Zhou, Janie Y Liang, Julia Michelotti, William H Dewey, Lisa Evans DeWald, Richard S Bennett, Patrick J Morris, Rajarshi Guha, Carleen Klumpp-Thomas, Crystal McKnight, Yu-Chi Chen, Xin Xu, Amy Wang, Emma Hughes, Scott Martin, Craig Thomas, Peter B Jahrling, Lisa E Hensley, Gene G Olinger, Judith M White
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005540 (2017)
Phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) is a lipid kinase involved in endosome maturation that emerged from a haploid genetic screen as being required for Ebola virus (EBOV) infection. Here we analyzed the effects of apilimod, a PIKfyve i
Externí odkaz:
https://doaj.org/article/19a1dce2d6914c7dbc9521614d84c222
Autor:
Jordi Bonaventura, Juan L. Gomez, Meghan L. Carlton, Sherry Lam, Marta Sanchez-Soto, Patrick J. Morris, Ruin Moaddel, Hye Jin Kang, Panos Zanos, Todd D. Gould, Craig J. Thomas, David R. Sibley, Carlos A. Zarate, Michael Michaelides
Publikováno v:
Mol Psychiatry
The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising developments for the treatment of depression. Nevertheless, racemic ketamine and (S)-ketamine are controlled substances with known abuse potential and their use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bae031142560fd647aa3a8a7cc11f6
https://europepmc.org/articles/PMC10013843/
https://europepmc.org/articles/PMC10013843/
Autor:
Jordi Bonaventura, Sherry Lam, Meghan Carlton, Matthew Boehm, Juan L. Gomez, Oscar Solís, Marta Sánchez-Soto, Patrick J. Morris, Ida Fredriksson, Craig J. Thomas, David R. Sibley, Yavin Shaham, Carlos A. Zarate, Michael Michaelides
Publikováno v:
Molecular Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1065fe6116f576947bad8a25873b6f41
https://doi.org/10.1038/s41380-022-01666-9
https://doi.org/10.1038/s41380-022-01666-9