Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Patrick J Grohar"'
Autor:
Maggie H Chasse, Benjamin K Johnson, Elissa A Boguslawski, Katie M Sorensen, Jessica E Rosien, Min H Kang, C Patrick Reynolds, Lyong Heo, Zachary B Madaj, Ian Beddows, Gabrielle E Foxa, Susan M Kitchen‐Goosen, Bart O Williams, Timothy J Triche, Patrick J Grohar
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-21 (2020)
Abstract Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic opti
Externí odkaz:
https://doaj.org/article/18bf94a3ea2d4e32b5861a62e60c62a8
Autor:
Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas Grünewald, Irfan A. Asangani
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110971- (2022)
Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription prog
Externí odkaz:
https://doaj.org/article/28e40682ce2f41f69b105d59455a86a7
Autor:
Jenna M. Gedminas, Rebecca Kaufman, Elissa A. Boguslawski, Amy C. Gross, Marie Adams, Ian Beddows, Susan M. Kitchen-Goosen, Ryan D. Roberts, Patrick J. Grohar
Publikováno v:
Molecular Cancer Therapeutics. 21:1296-1305
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric sarcoma with poor overall survival. This tumor is absolutely dependent on the continued expression and activity of its defining molecular lesion, the EWS–WT1 transcription factor. Unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd222714dfb30ea0b9a86716cb2076
https://doi.org/10.1158/1535-7163.mct-21-1003
https://doi.org/10.1158/1535-7163.mct-21-1003
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Data from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2842c1e98c596b51f5fdb72e255b4
https://doi.org/10.1158/1535-7163.22523076.v1
https://doi.org/10.1158/1535-7163.22523076.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Figure from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0d6d1d59dc549dbf7b79609c23fae
https://doi.org/10.1158/1535-7163.22523073
https://doi.org/10.1158/1535-7163.22523073
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
Laboratory values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501062fa1daa46709fce14f79900fb92
https://doi.org/10.1158/1535-7163.22518997.v1
https://doi.org/10.1158/1535-7163.22518997.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric sarcoma with poor overall survival. This tumor is absolutely dependent on the continued expression and activity of its defining molecular lesion, the EWS–WT1 transcription factor. Unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf9a8820f4734ec5b31091379f70cb8
https://doi.org/10.1158/1535-7163.c.6543585.v1
https://doi.org/10.1158/1535-7163.c.6543585.v1
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559f9c6213c0d59a323d14e5f5e7acc
https://doi.org/10.1158/1535-7163.c.6542218
https://doi.org/10.1158/1535-7163.c.6542218
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
Supplementary Table S2 and Supplementary Figures S1 to S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8472eb9ca9013fc5761a88b64872cbed
https://doi.org/10.1158/1535-7163.22519003.v1
https://doi.org/10.1158/1535-7163.22519003.v1
Autor:
Lee J. Helman, Arnulfo Mendoza, Maurizio D'Incalci, Yves Pommier, Choh Yeung, Laure E. Segars, Patrick J. Grohar
PDF file 74K, Growth curves showing mean tumor volume for cohorts of mice with the TC71 (top) and TC32 (bottom) xenografts for vehicle control (blue), trabectedin treatment (ET-743; Red), irinotecan (green) and trabectedin plus irinotecan (combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04681535ed8b0b949ee55b29017e6ea4
https://doi.org/10.1158/1078-0432.22448823
https://doi.org/10.1158/1078-0432.22448823