Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Patrick J Duriez"'
Autor:
Robert J Oldham, C Ian Mockridge, Sonya James, Patrick J Duriez, H T Claude Chan, Kerry L Cox, Vicentiu A Pitic, Mark S Cragg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleuki
Externí odkaz:
https://doaj.org/article/8f12a34eedcd4356b830ac47f7795691
Autor:
Clemens Hermann, Andy van Hateren, Nico Trautwein, Andreas Neerincx, Patrick J Duriez, Stefan Stevanović, John Trowsdale, Janet E Deane, Tim Elliott, Louise H Boyle
Publikováno v:
eLife, Vol 4 (2015)
Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whe
Externí odkaz:
https://doaj.org/article/ada3abf3139b4cf88664e56269726921
Autor:
Emma M Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J Duriez, Rebecca C Taylor, Sean P Cullen, Colin Adrain, Seamus J Martin
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e5055 (2009)
Members of the caspase family of cysteine proteases coordinate cell death through restricted proteolysis of diverse protein substrates and play a conserved role in apoptosis from nematodes to man. However, while numerous substrates for the mammalian
Externí odkaz:
https://doaj.org/article/2694c5ed2a8849ef8cf7796054f2aa09
Autor:
Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny Kim, H. T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT cell expressed CD27 provides costimulation upon binding to inducible membrane expressed trimeric CD70 and is required for protective CD8 T cell responses. CD27 agonists could therefore be used to bolster cellular vaccines and anti-tumou
Externí odkaz:
https://doaj.org/article/1b431c0777aa4151a8bb65c2e1304139
Autor:
Sergio Regufe da Mota, Sarah Bailey, Rosemary A. Strivens, Annette L. Hayden, Leon R. Douglas, Patrick J. Duriez, M. Teresa Borrello, Hanae Benelkebir, A. Ganesan, Graham Packham, Simon J. Crabb
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such
Externí odkaz:
https://doaj.org/article/4ce9ec32f7714957826dd1a3a38d81ad
Autor:
Stephen A. Beers, Mark S. Cragg, Martin J. Glennie, Jessica L. Teeling, Diego Gomez-Nicola, Patrick J. Duriez, Andrew J. Steele, Francesco Forconi, Ian Tracy, Salome Murinello, Kerry L. Cox, Alexander Earley, Rena Liu, Khiyam Hussain, Lang Dou, Lekh N. Dahal
This file contains supplementary data showing phenotypic/cytokine/chemokine changes in immune cell population following stimulation/tumour inoculation. The data also demonstrate that monocyte and neutrophil are not required for mAb mediated deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b512d898dbe1ff26b9592470f3760de
https://doi.org/10.1158/0008-5472.22414716
https://doi.org/10.1158/0008-5472.22414716
Autor:
Stephen A. Beers, Mark S. Cragg, Martin J. Glennie, Jessica L. Teeling, Diego Gomez-Nicola, Patrick J. Duriez, Andrew J. Steele, Francesco Forconi, Ian Tracy, Salome Murinello, Kerry L. Cox, Alexander Earley, Rena Liu, Khiyam Hussain, Lang Dou, Lekh N. Dahal
Tumors routinely attract and co-opt macrophages to promote their growth, angiogenesis, and metastasis. Macrophages are also the key effector cell for mAb therapies. Here we report that the tumor microenvironment creates an immunosuppressive signature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3b7826c615c5fc5826089fe7d7823c
https://doi.org/10.1158/0008-5472.c.6509061.v1
https://doi.org/10.1158/0008-5472.c.6509061.v1
Autor:
Denise S. M. Boulanger, Leon R. Douglas, Patrick J. Duriez, Yoyel Kang, Neil Dalchau, Edd James, Tim Elliott
Tapasin, a component of the major histocompatibility complex (MHC) I peptide loading complex, edits the repertoire of peptides that is presented at the cell surface by MHC I and thereby plays a key role in shaping the hierarchy of CD8+ T-cell respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1ffa0cf634a13b73ed3243dc48ed95
https://eprints.soton.ac.uk/476022/
https://eprints.soton.ac.uk/476022/
Autor:
Joseph R. Stephenson Clarke, Leon R. Douglas, Patrick J. Duriez, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Raniya Khadiullina, Emil Bulatov, Matthias G. J. Baud
Publikováno v:
ACS pharmacologytranslational science. 5(11)
The tumor suppressor protein p53 is inactivated in the majority of human cancers and remains a prime target for developing new drugs to reactivate its tumor suppressing activity for anticancer therapies. The oncogenic p53 mutant Y220C accounts for ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4c292cd3b44b8d4084ffa7acad8b2f
https://pubmed.ncbi.nlm.nih.gov/36407959
https://pubmed.ncbi.nlm.nih.gov/36407959
Autor:
Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews
Publikováno v:
Science Immunology
Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions. The human IgG2 isotype displays a unique capacity to undergo disulfide shuffling in the hinge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f26559ffaad774e3100f8f5c38f54b
https://pubmed.ncbi.nlm.nih.gov/35857582
https://pubmed.ncbi.nlm.nih.gov/35857582