Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Patrick J Atkinson"'
Autor:
Tomokatsu Udagawa, Patrick J Atkinson, Beatrice Milon, Julia M Abitbol, Yang Song, Michal Sperber, Elvis Huarcaya Najarro, Mirko Scheibinger, Ran Elkon, Ronna Hertzano, Alan G Cheng
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001445 (2021)
Cochlear supporting cells (SCs) are glia-like cells critical for hearing function. In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has been shown to nonmitotically regenerate SCs. Here
Externí odkaz:
https://doaj.org/article/6257f12c990547c7b8b5062d341a46d0
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Ruiqi Zhou, Akira Ishiyama, Lindsay S. Moore, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Jennifer C. Alyono, John Kveton, Dhasakumar Navaratnam, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate in
Externí odkaz:
https://doaj.org/article/bbd2c632a6e24a05853cb5f0c56c9d00
Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs.
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102077 (2014)
The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promote the regeneration of sensory hair cells in the mature cochlea and their reconnection with auditory neurons through the
Externí odkaz:
https://doaj.org/article/bf41839d25a340b6b6a6014a2d31cbbe
Autor:
Tomokatsu Udagawa, Erisa Takahashi, Norifumi Tatsumi, Hideki Mutai, Hiroki Saijo, Yuko Kondo, Patrick J. Atkinson, Tatsuo Matsunaga, Mamoru Yoshikawa, Hiromi Kojima, Masataka Okabe, Alan G. Cheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cochlear melanocytes are intermediate cells in the stria vascularis that generate endocochlear potentials required for auditory function. Human PAX3 mutations cause Waardenburg syndrome and abnormalities of skin and retinal melanocytes, mani
Externí odkaz:
https://doaj.org/article/56000f44d60b4f52be0cf622884bfdc6
Autor:
Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Clifford R Hume, Stephen J O'Leary, Robert K Shepherd, Rachael T Richardson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52338 (2012)
The cochlear implant provides auditory cues to profoundly deaf patients by electrically stimulating the residual spiral ganglion neurons. These neurons, however, undergo progressive degeneration after hearing loss, marked initially by peripheral fibr
Externí odkaz:
https://doaj.org/article/c6f87e92dea946a59d7d19dbbf4db9b2
Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea
Autor:
Ksenia A. Aaron, Katja Pekrun, Patrick J. Atkinson, Sara E. Billings, Julia M. Abitbol, Ina A. Lee, Yasmin Eltawil, Yuan-Siao Chen, Wuxing Dong, Rick F. Nelson, Mark A. Kay, Alan G. Cheng
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 413-428 (2023)
Adeno-associated virus (AAV)-mediated gene transfer has shown promise in rescuing mouse models of genetic hearing loss, but how viral capsid and promoter selection affects efficacy is poorly characterized. Here, we tested combinations of AAVs and pro
Externí odkaz:
https://doaj.org/article/12dd1baf9a7e41769ec3b2c66b940104
Autor:
Anping Xia, Tomokatsu Udagawa, Patricia M. Quiñones, Patrick J. Atkinson, Brian E. Applegate, Alan G. Cheng, John S. Oghalai
Publikováno v:
Journal of Neurophysiology. 128:1365-1373
The mammalian cochlea contains three rows of outer hair cells (OHCs) that amplify the basilar membrane traveling wave with high gain and exquisite tuning. The pattern of OHC loss caused by typical methods of producing hearing loss in animal models (n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d86271d551fe3cce0cce2af5d930dbb
https://doi.org/10.1152/jn.00501.2021
https://doi.org/10.1152/jn.00501.2021
Autor:
Tian Wang, Angela H. Ling, Sara E. Billings, Davood K. Hosseini, Yona Vaisbuch, Grace S. Kim, Patrick J. Atkinson, Zahra N. Sayyid, Ksenia A. Aaron, Dhananjay Wagh, Nicole Pham, Mirko Scheibinger, Akira Ishiyama, Peter Santa Maria, Nikolas H. Blevins, Robert K. Jackler, Stefan Heller, Ivan A. Lopez, Nicolas Grillet, Taha A. Jan, Alan G. Cheng
Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate remains unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d51fc5ccbf2422a031a62c457d223be
https://doi.org/10.1101/2022.10.29.514378
https://doi.org/10.1101/2022.10.29.514378
Autor:
Nicolas Grillet, Kyssia Ruth Mendoza, Dáibhid Ó Maoiléidigh, Katharine K. Miller, Patrick J. Atkinson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
The hair bundle is the mechanosensory organelle of hair cells that detects mechanical stimuli caused by sounds, head motions, and fluid flows. Each hair bundle is an assembly of cellular-protrusions called stereocilia, which differ in height to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9327bc8b062991016b1bcd6fe97be8b
https://doi.org/10.3389/fcell.2021.742529
https://doi.org/10.3389/fcell.2021.742529
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
The G protein-coupled receptor (GPR) family critically regulates development and homeostasis of multiple organs. As a member of the GPR adhesion family, Gpr125 (Adgra3) modulates Wnt/PCP signaling and convergent extension in developing zebrafish, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036c8b40ac200efbc6c428d66b856f37
https://www.frontiersin.org/articles/10.3389/fcell.2021.690955/full
https://www.frontiersin.org/articles/10.3389/fcell.2021.690955/full