Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Patrick J, Schuler"'
Autor:
Tsima Abou Kors, Matthias Meier, Lena Mühlenbruch, Annika C. Betzler, Franziska Oliveri, Martin Bens, Jaya Thomas, Johann M. Kraus, Johannes Doescher, Adrian von Witzleben, Linda Hofmann, Jasmin Ezic, Diana Huber, Julian Benckendorff, Thomas F. E. Barth, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Jonathan M. Blackburn, Thomas K. Hoffmann, Christian Ottensmeier, Hans A. Kestler, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis antigens (CTA)
Externí odkaz:
https://doaj.org/article/395296b0c62b42a7af04bb14da175331
Autor:
Danilo Aleo, Ziad Elshaer, Andreas Pfnür, Patrick J. Schuler, Marco Maria Fontanella, Christian Rainer Wirtz, Andrej Pala, Jan Coburger
Publikováno v:
Current Oncology, Vol 29, Iss 9, Pp 6594-6609 (2022)
The aim of the study was to assess the quality, accuracy and benefit of navigated 2D and 3D ultrasound for intra-axial tumor surgery in a prospective study. Patients intended for gross total resection were consecutively enrolled. Intraoperatively, a
Externí odkaz:
https://doaj.org/article/ff9f3e7fa1634d969bf79a932e250a85
Autor:
Linus L. Kienle, Leon R. Schild, Felix Böhm, Rene Grässlin, Jens Greve, Thomas K. Hoffmann, Patrick J. Schuler
Publikováno v:
Frontiers in Surgery, Vol 10 (2023)
BackgroundFor the surgical treatment of early-stage laryngeal cancer, the use of transoral laser microsurgery (TLM) has emerged as the gold standard. However, this procedure requires a straight line of sight to the operating field. Therefore, the pat
Externí odkaz:
https://doaj.org/article/db8d4479e91043b08ea257b090b9f7a3
Autor:
Linda Hofmann, Marie Waizenegger, Ralph Röth, Stefanie Schmitteckert, Daphne Engelhardt, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BackgroundEpithelial to mesenchymal transition (EMT) is a key process in carcinogenesis of head and neck squamous cell carcinoma (HNSCC), contributing to tumor invasiveness, distant metastasis, and recurrence. Exosomes are known mediators and regulat
Externí odkaz:
https://doaj.org/article/da495342c7434169a99bd62712d7b29c
Autor:
Franziska Leichtle, Annika C. Betzler, Carlotta Eizenberger, Kristina Lesakova, Jasmin Ezić, Robert Drees, Jens Greve, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Nils Cordes, Marialuisa Lavitrano, Emanuela Grassilli, Cornelia Brunner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13133 (2023)
Constitutively active kinases play a crucial role in carcinogenesis, and their inhibition is a common target for molecular tumor therapy. We recently discovered the expression of two oncogenic isoforms of Bruton’s Tyrosine Kinase (BTK) in head and
Externí odkaz:
https://doaj.org/article/a1d4d7b6d644440397af8d0cda55d2bd
Autor:
Linda Hofmann, Tsima Abou Kors, Jasmin Ezić, Beate Niesler, Ralph Röth, Sonja Ludwig, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Valentin Medyany, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Head and neck squamous cell carcinomas (HNSCC) lack tumor-specific biomarkers. Exosomes from HNSCC patients carry immunomodulatory molecules, and correlate with clinical parameters. We compared miRNA profiles of plasma- and saliva-derived
Externí odkaz:
https://doaj.org/article/f4b07b257ef04856b71e8b242130684a
Autor:
Linda Hofmann, Valentin Medyany, Jasmin Ezić, Ramin Lotfi, Beate Niesler, Ralph Röth, Daphne Engelhardt, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Edwin K. Jackson, Marie-Nicole Theodoraki
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundExosomes contribute to immunosuppression in head and neck squamous cell carcinoma (HNSCC), a tumor entity which lacks specific tumor biomarkers. Plasma-derived exosomes from HNSCC patients correlate with clinical parameters and have potenti
Externí odkaz:
https://doaj.org/article/b081436aafca40e187dd665805d0efb6
Autor:
Barbara-ann Guinn, Patrick J. Schuler, Hubert Schrezenmeier, Susanne Hofmann, Johanna Weiss, Christiane Bulach, Marlies Götz, Jochen Greiner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9285 (2023)
Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp
Externí odkaz:
https://doaj.org/article/68f05d842e334c0fb2f9bc4f2769c710
Autor:
Annika C. Betzler, Sebastian Kieser, Katja Fiedler, Simon Laban, Marie-Nicole Theodoraki, Patrick J. Schuler, Thomas Wirth, Kerry Tedford, Klaus-Dieter Fischer, Thomas K. Hoffmann, Cornelia Brunner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Btk and Vav proteins are all components of the signalosome that builds upon B cell receptor (BCR) activation. However, the role of Vav proteins within the signalosome is quite complex and not yet fully understood. Until now, studies of these have foc
Externí odkaz:
https://doaj.org/article/0c03eaa83f2e4a4ab5ae78c0b4bca5dc
Autor:
Adrian von Witzleben, Urs Müller-Richter, Katja Maurus, Stephanie Brändlein, Marie-Nicole Theodoraki, Cornelia Brunner, Simon Laban, Jochen Lennerz, Peter Möller, Thomas K. Hoffmann, Johannes Doescher, Patrick J. Schuler
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15835 (2022)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a
Externí odkaz:
https://doaj.org/article/abb4c3ab69d940c588fb3edeb1ba2d7e