Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Patrick J, Loll"'
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 133-139 (2024)
Vancomycin is a glycopeptide antibiotic that for decades has been a mainstay of treatment for persistent bacterial infections. However, the spread of antibiotic resistance threatens its continued utility. In particular, vancomycin-resistant enterococ
Externí odkaz:
https://doaj.org/article/be111e2df3cc483b9363f922a7efa8cf
Autor:
Eli H. Worth, Mark K. Fugate, Kimberly C. Grasty, Patrick J. Loll, Marilyn F. Bishop, Frank A. Ferrone
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Adults with sickle cell disease bear a mutation in the β-globin gene, leading to the expression of sickle hemoglobin (HbS; α2βS 2). Adults also possess the gene for γ-globin, which is a component of fetal hemoglobin (HbF, α2γ2); howeve
Externí odkaz:
https://doaj.org/article/569e0e8c44fa454d929edfe21d4ed1a3
Publikováno v:
ACS Bio & Med Chem Au, Vol 4, Iss 2, Pp 86-94 (2023)
Externí odkaz:
https://doaj.org/article/531c2862aa8f4e24bcec521754a929a8
Autor:
Alexandra A. Guffey, Patrick J. Loll
Publikováno v:
Microorganisms, Vol 9, Iss 10, p 2026 (2021)
Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new ther
Externí odkaz:
https://doaj.org/article/68062028ec504081adc7ddc4fa2251d9
Publikováno v:
Journal of Structural Biology: X, Vol 3, Iss , Pp - (2019)
The MJD family of human deubiquitinating enzymes contains four members: Ataxin-3, the ataxin-3-like protein (AT3L), Josephin-1, and Josephin-2. All share a conserved catalytic unit known as the Josephin domain. Ataxin-3 and AT3L also contain extensiv
Externí odkaz:
https://doaj.org/article/d4247c1da0b640f989176b7e1fd35abf
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210627 (2019)
VanS is a membrane-bound sensor histidine kinase responsible for sensing vancomycin and activating transcription of vancomycin-resistance genes. In the presence of vancomycin, VanS phosphorylates the transcription factor VanR, converting it to its tr
Externí odkaz:
https://doaj.org/article/8ecc8df841e444a8892eeea191988990
Autor:
Kimberly C. Grasty, Claudia Guzik, Elizabeth J. D’Lauro, Shae B. Padrick, Joris Beld, Patrick J. Loll
The VanRS two-component system regulates the resistance phenotype of vancomycin-resistant enterococci (VRE). VanS is a sensor histidine kinase that responds to the presence of vancomycin by autophosphorylating and subsequently transferring the phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::621abfdc3dbe65714a71176e1fa3b595
https://doi.org/10.1101/2022.12.12.520123
https://doi.org/10.1101/2022.12.12.520123
Autor:
Mehmet Berkmen, Marine Lénon, Guoping Ren, Megan E. Meuser, Patrick J. Loll, Paul Riggs, Na Ke
Publikováno v:
Protein Sci
Maltose binding protein (MBP) is used in recombinant protein expression as an affinity and solubility tag. The monoclonal antibody B48 binds MBP tightly and has no cross‐reactivity to other proteins in an Escherichia coli lysate. This high level of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30a3c6c4709caa6b91c02f0e0ec2c59
https://doi.org/10.1002/pro.4088
https://doi.org/10.1002/pro.4088
Autor:
Kimberly C. Grasty, Claudia Guzik, Elizabeth J. D’Lauro, Shae B. Padrick, Joris Beld, Patrick J. Loll
Publikováno v:
Journal of Biological Chemistry. 299:103001
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86a950e2c99093efb4ce622ce8b0bb71
https://doi.org/10.1016/j.jbc.2023.103001
https://doi.org/10.1016/j.jbc.2023.103001
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7aa96d9de19eae8413db42d06f9ae4
https://doi.org/10.1096/fasebj.2022.36.s1.r5594
https://doi.org/10.1096/fasebj.2022.36.s1.r5594