Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Patrick J, Guiry"'
Autor:
Lucy Byrne, Patrick J. Guiry
Publikováno v:
Molecules, Vol 29, Iss 10, p 2233 (2024)
This review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM ana
Externí odkaz:
https://doaj.org/article/c2a13370d72c450c93c8b37ccbe755a4
Publikováno v:
Molecules, Vol 27, Iss 18, p 6078 (2022)
Herein, we report the design and synthesis of a series of chiral pyrrolidine-substituted ferrocene-derived ligands. The proficiency of this novel structural motif was demonstrated in the Rh-catalyzed asymmetric hydrogenation of dehydroamino acid este
Externí odkaz:
https://doaj.org/article/8842fbf75a3847799203ecb4944bd846
Publikováno v:
Transition‐Metal‐Catalyzed C‐H Functionalization of Heterocycles. :435-484
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405640d03d8e80b65f290365f92fcd7f
https://doi.org/10.1002/9781119774167.ch10
https://doi.org/10.1002/9781119774167.ch10
Publikováno v:
Synthesis. 55:1274-1284
Lipoxins are an important class of pro-resolving mediators that play a crucial role in the resolution of inflammation. Thus, the synthesis of more metabolically stable synthetic lipoxin analogues is an area of significant interest. Herein the asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b3566610331e610c39855fc24afbc4
https://doi.org/10.1055/a-1992-7148
https://doi.org/10.1055/a-1992-7148
Publikováno v:
Chemistry – A European Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87964bff525c59fa4f8c68db6f3dba43
https://doi.org/10.1002/chem.202382861
https://doi.org/10.1002/chem.202382861
Publikováno v:
Chemistry – A European Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e769fe639b4bfb34d5abbbd993325a26
https://doi.org/10.1002/chem.202300296
https://doi.org/10.1002/chem.202300296
Autor:
Catherine Tighe, Monica de Gaetano, Andrea Zanetti, Catherine Godson, Jianmin Chen, Patrick J. Guiry, Mark E. Cooper, Xavier Leroy, Kevin Gahan, Eoin P. Brennan, Derek W. Gilroy, Antonino Cacace, Mauro Perretti, Mariam Marai, Justine Newson, Andrew Gaffney, Phillip Kantharidis
Publikováno v:
Journal of Medicinal Chemistry
Failure to resolve inflammation underlies many prevalent pathologies. Recent insights have identified lipid mediators, typified by lipoxins (LXs), as drivers of inflammation resolution, suggesting potential therapeutic benefit. We report the asymmetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0a8aae72d9162c7a12aafaa264eb1
https://doi.org/10.1021/acs.jmedchem.1c00403
https://doi.org/10.1021/acs.jmedchem.1c00403
Publikováno v:
Organic letters. 24(32)
Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bdbaa504d72997626c1dd98fb43a8e7
https://pubmed.ncbi.nlm.nih.gov/35938947
https://pubmed.ncbi.nlm.nih.gov/35938947
Publikováno v:
Chemical Reviews
The chiral oxazoline motif is present in many ligands that have been extensively applied in a series of important metal-catalyzed enantioselective reactions. This Review aims to provide a comprehensive overview of the most significant applications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71fe253231000e070e40849953e03a9
http://europepmc.org/articles/PMC8277118
http://europepmc.org/articles/PMC8277118
Autor:
Eric Judge, Patrick J. Guiry, Jan-E. Bäckvall, Andreas Pfaltz, Jèssica Margalef, Christina Moberg, Montserrat Diéguez, Santiago Cañellas, Oscar Pàmies, Miquel A. Pericàs, Jinju James
Publikováno v:
Chemical Reviews
This Review compiles the evolution, mechanistic understanding, and more recent advances in enantioselective Pd-catalyzed allylic substitution and decarboxylative and oxidative allylic substitutions. For each reaction, the catalytic data, as well as e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bf0a2465e266fd7ec643e7ed162b31
https://doi.org/10.1021/acs.chemrev.0c00736
https://doi.org/10.1021/acs.chemrev.0c00736