Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Patrick J, Grohar"'
Autor:
David S. Shulman, Sarah B. Whittle, Didier Surdez, Kelly M. Bailey, Enrique de Álava, Jason T. Yustein, Adam Shlien, Masanori Hayashi, Alexander J. R. Bishop, Brian D. Crompton, Steven G. DuBois, Neerav Shukla, Patrick J. Leavey, Stephen L. Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G. P. Grünewald, Cristina R. Antonescu, Ryan D. Roberts, Jeffrey A. Toretsky, Franck Tirode, Richard Gorlick, Katherine A. Janeway, Damon Reed, Elizabeth R. Lawlor, Patrick J. Grohar
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60–80% of patien
Externí odkaz:
https://doaj.org/article/85d5d49a92054aefa68b0e44c262da64
Autor:
Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas Grünewald, Irfan A. Asangani
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110971- (2022)
Summary: Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription prog
Externí odkaz:
https://doaj.org/article/28e40682ce2f41f69b105d59455a86a7
Autor:
Maggie H Chasse, Benjamin K Johnson, Elissa A Boguslawski, Katie M Sorensen, Jessica E Rosien, Min H Kang, C Patrick Reynolds, Lyong Heo, Zachary B Madaj, Ian Beddows, Gabrielle E Foxa, Susan M Kitchen‐Goosen, Bart O Williams, Timothy J Triche, Patrick J Grohar
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-21 (2020)
Abstract Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic opti
Externí odkaz:
https://doaj.org/article/18bf94a3ea2d4e32b5861a62e60c62a8
Autor:
Guillermo Flores, Patrick J. Grohar
Publikováno v:
Journal of Bone Oncology, Vol 31, Iss , Pp 100404- (2021)
EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant transformation and progression and occurs in a genetic background characterized by few other recurrent cooperating mutations. In addition, the tumor is absolutely depen
Externí odkaz:
https://doaj.org/article/9a77022905d64e55b420921ad169d37f
Autor:
Michael D. Kinnaman, Chong Zhu, Daniel A. Weiser, Sana Mohiuddin, Pooja Hingorani, Michael Roth, Jonathan Gill, Katherine A. Janeway, Richard Gorlick, Stephen L. Lessnick, Patrick J. Grohar
Publikováno v:
Sarcoma, Vol 2020 (2020)
Advances in molecular diagnostics have identified subsets of Ewing and Ewing-like sarcomas driven by variant translocations with unique biology. It is likely that patients with these tumours will have different clinical features and therapeutic outco
Externí odkaz:
https://doaj.org/article/0cb2bb6b9dd74e829cda56f08e8b7271
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Data from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2842c1e98c596b51f5fdb72e255b4
https://doi.org/10.1158/1535-7163.22523076.v1
https://doi.org/10.1158/1535-7163.22523076.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Supplementary Figure from Lurbinectedin Inhibits the EWS–WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b0d6d1d59dc549dbf7b79609c23fae
https://doi.org/10.1158/1535-7163.22523073
https://doi.org/10.1158/1535-7163.22523073
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
Laboratory values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501062fa1daa46709fce14f79900fb92
https://doi.org/10.1158/1535-7163.22518997.v1
https://doi.org/10.1158/1535-7163.22518997.v1
Autor:
Patrick J. Grohar, Ryan D. Roberts, Susan M. Kitchen-Goosen, Ian Beddows, Marie Adams, Amy C. Gross, Elissa A. Boguslawski, Rebecca Kaufman, Jenna M. Gedminas
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric sarcoma with poor overall survival. This tumor is absolutely dependent on the continued expression and activity of its defining molecular lesion, the EWS–WT1 transcription factor. Unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf9a8820f4734ec5b31091379f70cb8
https://doi.org/10.1158/1535-7163.c.6543585.v1
https://doi.org/10.1158/1535-7163.c.6543585.v1
Autor:
Patrick J. Grohar, Lee J. Helman, Natasha J. Caplen, Scott E. Martin, Susan M. Kitchen-Goosen, Carleen A. Klumpp-Thomas, Marie Adams, Sergey Dikalov, Ian Beddows, Zachary B. Madaj, Brandon M. Oswald, Elissa A. Boguslawski, Joel H. Everett, Guillermo Flores
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559f9c6213c0d59a323d14e5f5e7acc
https://doi.org/10.1158/1535-7163.c.6542218
https://doi.org/10.1158/1535-7163.c.6542218