Výsledky vyhledávání - "Patrick I. Ferrell"

The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells

Autor: Dan S. Kaufman, Jiafei Xi, Chao Ma, Mitali Adlakha, Patrick I. Ferrell

Publikováno v: Stem cells (Dayton, Ohio), vol 33, iss 4

Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41690fc30d00ff855458d056d534089f
https://escholarship.org/uc/item/9gk8q210

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Functional Assessment of Hematopoietic Niche Cells Derived from Human Embryonic Stem Cells

Autor: Mike Lepley, Patrick I. Ferrell, Melinda K. Hexum, Ross A. Kopher, Dan S. Kaufman, Amanda Gussiaas

Publikováno v: Stem cells and development, vol 23, iss 12

To evaluate hematopoietic niche cell populations isolated from human embryonic stem cells (hESCs), we tested the ability of hESC-derived stromal lines to support CD34(+) umbilical cord blood (UCB)- and hESC-derived CD34(+)45(+) cells in long-term cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6afbc3450f8a150d087feaf966fed73
https://europepmc.org/articles/PMC4046207/

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The RUNX1-Regulated Cebpa +37 Kb Enhancer Directs Human CD4 Transgene Expression To Long-Term Hematopoietic Stem Cells and Preferentially To Myeloid Compared With Lymphoid Or Erythroid Progenitors

Autor: Leonard I. Zon, Ilya Shestopalov, Hong Guo, Patrick I. Ferrell, Alan D. Friedman, Dan S. Kaufman, Ou Ma

Publikováno v: Blood. 122:2442-2442

We found that adult mice lacking RUNX1 have increased monopoiesis relative to granulopoiesis correlated with reduce Cebpa RNA expression in myeloid progenitors and that RUNX1 binds and activates Cebpa reporters via two sites in the Cebpa promoter and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db3833bc7675a6fbb8b3fc591306ba2f
https://doi.org/10.1182/blood.v122.21.2442.2442

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Effective Development of Hematopoietic Niche Cells From hESCs: hESC-Derived Stromal Cells Support LTC-ICs Better Than Bone Marrow-Derived Stromal Cells

Autor: Patrick I. Ferrell, Melinda K. Hexum, Amanda Gussiaas, Ross A. Kopher, Mike Lepley, Dan S. Kaufman

Publikováno v: Blood. 118:4804-4804

Abstract 4804 Quantification of putative hematopoietic stem cells (HSCs) in human bone marrow or cord blood is typically assessed by its potential to mediate long-term, multilineage engraftment when transplanted into immunodeficient murine recipients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d56e059eb7b18d8bd3cc0142618c3af
https://doi.org/10.1182/blood.v118.21.4804.4804

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