Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Patrick Hurban"'
Autor:
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays
Externí odkaz:
https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab
Autor:
Richard A. Blidner, Gary J. Latham, Sarah Schmitt, Ziyan Y. Pessetto, Dan Su, Robyn D. Cardwell, Andrew K. Godwin, Stephen Hyter, Léon C van Kempen, Shobha Gokul, Maria Aguirre, Patrick Hurban, Brian C. Haynes
Publikováno v:
The Journal of Molecular Diagnostics : JMD
Lung cancer accounts for approximately 14% of all newly diagnosed cancers and is the leading cause of cancer-related deaths. Chimeric RNA resulting from gene fusions (RNA fusions) and other RNA splicing errors are driver events and clinically address
Autor:
Stephen S. Ferguson, Parth Kothiya, Stephen Siferd, Imran Shah, Jessica A. Bonzo, John F. Wambaugh, John Jack, Rafal P. Witek, Susan D. Hester, Keith A. Houck, Jill A Franzosa, Patrick Hurban, Nancy C. Baker
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays have eval
Abstract 4485: Comparison of two commercially available T cell receptor repertoire sequencing assays
Publikováno v:
Cancer Research. 80:4485-4485
Background: Deep sequencing of the T-cell receptor complementarity-determining regions assists with resolving T-cell diversity, and, in oncology, detects specific clones or changes in clonality associated with anti-tumor responses. However, the extre
Publikováno v:
Cancer Research. 80:3114-3114
While tissue biopsies and imaging techniques remain the current standard of care, minimally invasive liquid biopsy tests are emerging as compelling complements in the clinical management of cancer patients. The ability to accurately detect low freque
Autor:
Victor J. Weigman, Rajiv Raja, Tingting Jiang, Stephanie B. Hastings, Philip Brohawn, Gunjan Hariani, Chen Zhao, Patrick Hurban, Traci Pawlowski
Publikováno v:
Cancer Research. 79:1346-1346
Checkpoint inhibitor (CPI) therapy demonstrates a remarkable clinical benefit in many cancer types. However, the ability to successfully select patients who will benefit from CPIs is still limited. Tumor mutational burden (TMB), a measure of the numb
Abstract 1626: Sensitive detection of MET exon 14 skipping by RT-qPCR and next generation sequencing
Publikováno v:
Cancer Research. 78:1626-1626
The MET receptor tyrosine kinase (MET) gene is a proto-oncogene whose abnormal activation can trigger tumor growth, angiogenesis, and metastasis. Numerous mutations have been identified that lead to over-activation of the gene, including well charact
Publikováno v:
Cancer Research. 78:429-429
RNA-sequencing (RNA-seq) is an effective tool for gene expression analysis, promising to be a diagnostic tool for patient stratification and individualized therapy. However, it has been challenging to apply RNA-seq to low-quantity and degraded RNA de
Autor:
Alan Brunner, Glenda C. Delenstarr, Timothy K. McDaniel, Lisa J. Croner, Chunlin Xiao, Raymond R. Samaha, Wen Yang, Lei Guo, Stephen J. Walker, Terry Osborn, Federico Goodsaid, P. Scott Pine, J. Christopher Corton, Yuling Luo, Yaron Turpaz, Alexander Wong, Raj K. Puri, Jean Thierry-Mieg, Michael A Wilson, Anne Bergstrom Lucas, Heather Harbottle, Eli Hatchwell, Donna Brown, Jie Wu, Shawn Levy, Wendell D. Jones, Ola Myklebost, Craig A. Hauser, Vincent Bertholet, J. Eugene LeClerc, David J. Dix, Scott A. Jackson, Eugene Chudin, Beena Vallanat, Susan D. Hester, Mark Schena, Barry A. Rosenzweig, James J. Chen, Paul K. Wolber, Adam Papallo, Yongming Andrew Sun, Shawn C. Baker, Uwe Scherf, Zoltan Szallasi, William Slikker, Kenneth L. Philips, Xutao Deng, Lajos Pusztai, Sue Jane Wang, Janet Hager, Xu Guo, Tao Han, Charles Wang, Frank Staedtler, Hongmei Sun, Svetlana Shchegrova, Christopher Davies, Liang Zhang, James C. Willey, Yaping Zong, Kathleen Y. Lee, Paul K. Haje, James C. Fuscoe, Ying Liu, Natalia Novoradovskaya, Russell D. Wolfinger, Kathryn Gallagher, Roderick V. Jensen, Feng Qian, Wenjun Bao, Christophe Van, Bud Bromley, Janet A. Warrington, Leming Shi, Tucker A. Patterson, David Dorris, Huixiao Hong, Winston Patrick Kuo, Hongzu Ren, Xiaoxi Megan Cao, Cecilie Boysen, Michael S. Orr, Danielle Thierry-Mieg, Xiaohui Fan, Felix W. Frueh, Gary P. Schroth, Yonghong Wang, Chunmei Liu, Yunqing Ma, Shashi Amur, Lu Zhang, Michael Lombardi, Dave D. Smith, Tzu Ming Chu, Jun Xu, Charles D. Johnson, Baitang Ning, Timothy Davison, Botoul Maqsodi, Karol L. Thompson, Thomas A. Cebula, Richard Shippy, Edward K. Lobenhofer, Weida Tong, Quan Zhen Li, Catalin Barbacioru, Qian Xie, Aron Charles Eklund, Ernest S. Kawasaki, Patrick J. Collins, Zivana Tezak, Elizabeth Herness Peters, Francoise de Longueville, Stephanie Fulmer-Smentek, Hong Fang, Patrick Hurban, Scott R. Magnuson, Hanlee P. Ji, Roger Perkins, Mitch Rosen, Ron L. Peterson, Weigong Ge, Stephen C. Harris, Sheng Zhong, Charles R. Knight, Damir Herman, Zhenqiang Su, Roger D. Canales, Nan Mei, Jing Cheng, Irina Tikhonova, Gavin M. Fischer, Laura H. Reid, Robert Setterquist, Yvonne P. Dragan, Jing Han, John F. Corson
Publikováno v:
Nature Biotechnology. 24:1151-1161
Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to an
Autor:
Christopher J. Portier, Milton R. Hejtmancik, Patrick Hurban, Molly Vallant, Gary A. Boorman, Greg Travlos, Richard D. Irwin, April M. Brys, Diane K. Gerken, Edward K. Lobenhofer, Joel S. Parker
Publikováno v:
Toxicologic Pathology. 33:102-110
A new tool beginning to have wider application in toxicology studies is transcript profiling using microarrays. Microarrays provide an opportunity to directly compare transcript populations in the tissues of chemical-exposed and unexposed animals. Wh