Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation

Autor: Derek R. Boyd, Narain D. Sharma, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen, Patrick M. Dansette

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 909, p 909 (2022)
Boyd, D R, Sharma, N D, Stevenson, P J, Hoering, P, Allen, C C R & Dansette, P M 2022, ' Monooxygenase-and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation ', International Journal of Molecular Sciences, vol. 23, no. 2, 909 . https://doi.org/10.3390/ijms23020909
International Journal of Molecular Sciences

Enzymatic oxidations of thiophenes, including thiophene-containing drugs, are important for biodesulfurization of crude oil and drug metabolism of mono- and poly-cyclic thiophenes. Thiophene oxidative dearomatization pathways involve reactive metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74d240ecc404009631677744c2e8ec1
https://www.mdpi.com/1422-0067/23/2/909

Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides

Autor: Patrick Hoering, Jonathan G. Carroll, Derek R. Boyd, Paul J. Stevenson, Pui L. Loke, Christopher C. R. Allen, Narain D. Sharma

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Boyd, D, Das Sharma, N, Loke, P L, Carroll, J G, Stevenson, P, Hoering, P & Allen, C C R 2021, ' Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides ', Frontiers in Bioengineering and Biotechnology . https://doi.org/10.3389/fbioe.2020.619175

Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a273fdf47f1c25f585df9063d9068dd
https://www.frontiersin.org/articles/10.3389/fbioe.2020.619175/full

cis‐Dihydroxylation of Tricyclic Arenes and Heteroarenes Catalyzed by Toluene Dioxygenase: A Molecular Docking Study and Experimental Validation

Autor: Christopher J. McGivern, Christopher C. R. Allen, Ian N. Brannigan, Derek R. Boyd, Narain D. Sharma, Colin McRoberts, Peter Nockemann, Patrick Hoering, Paul J. Stevenson

Publikováno v: Boyd, D, Sharma, N D, Brannigan, I, McGivern, C, Nockemann, P, Stevenson, P, McRoberts, C, Hoering, P & Allen, C C R 2019, ' cis-Dihydroxylation of Tricyclic Arenes and Heteroarenes Catalyzed by Toluene Dioxygenase: A Molecular Docking Study and Experimental Validation ', Advanced Synthesis & Catalysis . https://doi.org/10.1002/adsc.201900147

Molecular docking studies of toluene dioxygenase (TDO) led to the prediction that angular and lateral cis‐dihydroxylation of tricyclic arene and heteroarene substrates could occur. Biotransformations of biphenylene, dibenzofuran, carbazole and dibe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb12ef426b292992c8055c73cf641007
https://pure.qub.ac.uk/en/publications/cisdihydroxylation-of-tricyclic-arenes-and-heteroarenes-catalyzed-by-toluene-dioxygenase-a-molecular-docking-study-and-experimental-validation(50853b4a-7862-402a-80bc-d5045176e60a).html

Draft genome sequences of Pseudomonas putida UV4 and UV4/95, toluene dioxygenaseexpressing producers of cis-1,2-dihydrodiols

Autor: Christopher C. R. Allen, Patrick Hoering, Roger C. Whitehead, Timofey Skvortsov, Derek R. Boyd, Ksenia Arkhipova

Publikováno v: Skvortsov, T, Hoering, P, Arkhipova, K, Whitehead, R C, Boyd, D R & Allen, C C R 2018, ' Draft genome sequences of Pseudomonas putida UV4 and UV4/95, toluene dioxygenaseexpressing producers of cis-1,2-dihydrodiols ', Genome Announcements, vol. 6, no. 1, e01419-17, pp. 1-2 . https://doi.org/10.1128/genomeA.01419-17
Skvortsov, T, Hoering, P, Arkhipova, K, Whitehead, R, Boyd, D R & Allen, C C R 2018, ' Draft Genome Sequences of Pseudomonas putida UV4 and UV4/95, Toluene Dioxygenase-Expressing Producers of cis-1,2-Dihydrodiols ', Genome Announcements, vol. 4, no. 1, e01419-17 . https://doi.org/10.1128/genomeA.01419-17

Here, we present draft genome sequences of Pseudomonas putida strains UV4 and UV4/95, which demonstrate an ability to conduct a wide range of industrially important biotransformations of arenes, alkenes, and phenols.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5e762ab771dfaa7673462a972134e9
https://pure.qub.ac.uk/en/publications/draft-genome-sequences-of-pseudomonas-putida-uv4-and-uv495-toluene-dioxygenaseexpressing-producers-of-cis12dihydrodiols(934c289e-874e-46a1-92ee-927302a71b73).html