Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Patrick Ho-yu Chung"'
Autor:
Zhixin Li, Kathy Nga-Chu Lui, Sin-Ting Lau, Frank Pui-Ling Lai, Peng Li, Patrick Ho-Yu Chung, Kenneth Kak-Yuen Wong, Paul Kwong-Hing Tam, Maria-Mercedes Garica-Barcelo, Chi-Chung Hui, Pak Chung Sham, Elly Sau-Wai Ngan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells, leading to intestinal obstruction. Here, using induced pluripotent stem cell-based models of Hirschsprung and single
Externí odkaz:
https://doaj.org/article/900f75b8630e4433832db65c3d9cbb22
Autor:
Vincent Chi-Hang Lui, Kenrie Pui-Yan Hui, Rosanna Ottakandathil Babu, Haibing Yue, Patrick Ho-Yu Chung, Paul Kwong-Hang Tam, Michael Chi-Wai Chan, Kenneth Kak-Yuen Wong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Although the main route of infection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory tract, liver injury is also commonly seen in many patients, as evidenced by deranged parenchymal liver enzymes. Furtherm
Externí odkaz:
https://doaj.org/article/1bab0293cb384c0ab4cb4c68c6c28511
Autor:
Patrick Ho-Yu Chung, Rosana Ottakandathil Babu, Zhongluan Wu, Kenneth Kak-Yuen Wong, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 2, Pp 644-653 (2022)
Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C). Methods: Organoids were developed from the liver parenchyma collected during Kasai portoenterosto
Externí odkaz:
https://doaj.org/article/5c1f686ffe4946fbb749b3fe90c426b3
Autor:
Wai-Yee Lam, Clara Sze-Man Tang, Man-Ting So, Haibing Yue, Jacob Shujui Hsu, Patrick Ho-Yu Chung, John M. Nicholls, Fanny Yeung, Chun-Wai Davy Lee, Diem Ngoc Ngo, Pham Anh Hoa Nguyen, Hannah M. Mitchison, Dagan Jenkins, Christopher O'Callaghan, Maria-Mercè Garcia-Barceló, So-Lun Lee, Pak-Chung Sham, Vincent Chi-Hang Lui, Paul Kwong-Hang Tam
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103530- (2021)
Background: Biliary atresia (BA) is the most common obstructive cholangiopathy in neonates, often progressing to end-stage cirrhosis. BA pathogenesis is believed to be multifactorial, but the genetic contribution, especially for nonsyndromic BA (comm
Externí odkaz:
https://doaj.org/article/de3d870458914c54bce3e247eeaeb86d
Autor:
Guo Cheng, Patrick Ho-Yu Chung, Edwin Kin-Wai Chan, Man-Ting So, Pak-Chung Sham, Stacey S. Cherny, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-9 (2017)
Abstract Background Biliary Atresia (BA) is rare and genetically complex, and the pathogenesis is elusive. The disease course is variable and can represent heterogeneity, which hinders effective disease management. Deciphering the BA phenotypic varia
Externí odkaz:
https://doaj.org/article/98007cc650c84dbca87933c317603a91
Autor:
Clara Sze-Man Tang, Guo Cheng, Man-Ting So, Benjamin Hon-Kei Yip, Xiao-Ping Miao, Emily Hoi-Man Wong, Elly Sau-Wai Ngan, Vincent Chi-Hang Lui, You-Qiang Song, Danny Chan, Kenneth Cheung, Zhen-Wei Yuan, Liu Lei, Patrick Ho-Yu Chung, Xue-Lai Liu, Kenneth Kak-Yuen Wong, Christian R. Marshall, Stephen Scherer, Stacey S. Cherny, Pak-Chung Sham, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
PLoS Genetics, Vol 8, Iss 5 (2012)
Externí odkaz:
https://doaj.org/article/fc0f1f3006d949558b6a043db307c4ed
Autor:
Clara Sze-Man Tang, Guo Cheng, Man-Ting So, Benjamin Hon-Kei Yip, Xiao-Ping Miao, Emily Hoi-Man Wong, Elly Sau-Wai Ngan, Vincent Chi-Hang Lui, You-Qiang Song, Danny Chan, Kenneth Cheung, Zhen-Wei Yuan, Liu Lei, Patrick Ho-Yu Chung, Xue-Lai Liu, Kenneth Kak-Yuen Wong, Christian R Marshall, Stephen W Scherer, Stacey S Cherny, Pak-Chung Sham, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002687 (2012)
Hirschsprung disease (HSCR) is a congenital disorder characterized by aganglionosis of the distal intestine. To assess the contribution of copy number variants (CNVs) to HSCR, we analysed the data generated from our previous genome-wide association s
Externí odkaz:
https://doaj.org/article/e39739e82bd9432eb791bfa1368ea972
Autor:
Clara Sze-Man Tang, Wai-Kiu Tang, Man-Ting So, Xiao-Ping Miao, Brian Man-Chun Leung, Benjamin Hon-Kei Yip, Thomas Yuk-Yu Leon, Elly Sau-Wai Ngan, Vincent Chi-Hang Lui, Yan Chen, Ivy Hau-Yee Chan, Patrick Ho-Yu Chung, Xue-Lai Liu, Xuan-Zhao Wu, Kenneth Kak-Yuen Wong, Pak-Chung Sham, Stacey S Cherny, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barceló
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16181 (2011)
The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis) is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction. HSCR is attributed to a failure of migration of the enteric ganglion precur
Externí odkaz:
https://doaj.org/article/39a9cfed9fb8422d9b3f7b1bde1ab4ba
Autor:
Man-Ting So, Thomas Yuk-Yu Leon, Guo Cheng, Clara Sze-Man Tang, Xiao-Ping Miao, Belinda K Cornes, Ngoc Ngo Diem, Long Cui, Elly Sau-Wai Ngan, Vincent Chai-Hang Lui, Xuan-Zhao Wu, Bin Wang, Hualong Wang, Zheng-Wei Yuan, Liu-Ming Huang, Long Li, Huimin Xia, Deli Zhu, Juncheng Liu, Thanh Liem Nguyen, Ivy Hau-Yee Chan, Patrick Ho-Yu Chung, Xue-Lai Liu, Ruizhong Zhang, Kenneth Kak-Yuen Wong, Pak-Chung Sham, Stacey S Cherny, Paul Kwong-Hang Tam, Maria-Mercè Garcia-Barcelo
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28986 (2011)
Rare (RVs) and common variants of the RET gene contribute to Hirschsprung disease (HSCR; congenital aganglionosis). While RET common variants are strongly associated with the commonest manifestation of the disease (males; short-segment aganglionosis;
Externí odkaz:
https://doaj.org/article/2bc637cd25a94f7abcae0723d404adea
Autor:
Hongyu Lyu, Yongqin Ye, Vincent Chi Hang Lui, Weifang Wu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Hung-Wing Li, Man Shing Wong, Paul Kwong Hang Tam, Bin Wang
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
BackgroundBiliary atresia (BA) is an infantile fibro-obstructive cholestatic disease with poor prognosis. An early diagnosis and timely Kasai portoenterostomy (KPE) improve clinical outcomes. Aggregation of amyloid-beta (Aβ) around hepatic bile duct
Externí odkaz:
https://doaj.org/article/413a2de983a3431faaa027097c20c71f