Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick Hautefaye"'
Autor:
Anne Bretéché, Pascal Marchand, Marie-Renée Nourrisson, Patrick Hautefaye, Guillaume De Nanteuil, Muriel Duflos
Publikováno v:
Tetrahedron. 67:4767-4773
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38e137cff297ef6bc7b9f622580a4745
https://doi.org/10.1016/j.tet.2011.05.035
https://doi.org/10.1016/j.tet.2011.05.035
Autor:
Patrick Hautefaye, Gilbert Lavielle, Sébastien Didier, Christian Bailly, Amélie Lansiaux, Alain Pierré, Marie-Hélène David-Cordonnier, Romain Mazinghien, Laurence Kraus-Berthier, Christine Bal-Mahieu, Stéphane Léonce, John A. Hickman
Publikováno v:
Molecular Pharmacology. 72:311-319
The E-ring lactone is the Achilles' heel of camptothecin derivatives: although it is considered necessary for the inhibition of the enzyme topoisomerase I (topo1), the opening of the lactone into a carboxylate abolishes the generation of topo1-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d5047497a8d0995dc48e458cea9ce
https://doi.org/10.1124/mol.107.034637
https://doi.org/10.1124/mol.107.034637
Publikováno v:
Neuropsychopharmacology. 26:552-556
Employing a two-lever, food-reinforced, Fixed Ratio 10 drug discrimination procedure, rats were trained to recognize the highly-selective serotonin (5-HT)(2A) receptor antagonist, MDL100,907 (0.16 mg/kg, i.p.). They attained criterion after a mean +/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63dbb610d89d9f9273fc2c81bd3a5c0
https://doi.org/10.1016/s0893-133x(01)00389-x
https://doi.org/10.1016/s0893-133x(01)00389-x
Autor:
Patrick Hautefaye, Marie-Renée Nourrisson, Pascal Marchand, Guillaume De Nanteuil, Anne Breteche, Muriel Duflos
Publikováno v:
ChemInform. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bedd2ef69b778491de3a6f84018a52c6
https://doi.org/10.1002/chin.201146159
https://doi.org/10.1002/chin.201146159
Publikováno v:
Tetrahedron Letters. 34:2315-2318
N-tosyl-oxiraneethylamines undergo cyclization upon treatment with aqueous sodium hydroxide to afford either N-tosyl-azetidinemethanols or N-tosyl-pyrrolidin-3-ols in high yields. The change in regioselectivity of this cyclization process is quite de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35db80a85e1c8a0cdac57c041425536
https://doi.org/10.1016/s0040-4039(00)77602-7
https://doi.org/10.1016/s0040-4039(00)77602-7
Autor:
Jean A. Boutin, Valérie Pérez, Gilbert Lavielle, Alain Pierré, Patrick Hautefaye, Ghanem Atassi, D. Saint-Dizier, Stéphane Léonce
Publikováno v:
Cancer chemotherapy and pharmacology. 29(5)
S12363, a new vinca alkaloid derivative, was considerably more cytotoxic to murine L1210 cells and five human tumor cell lines (HL60, HT-29, COLO 320DM, NCI-H460, and PANC-1) than was vincristine (VCR) or vinblastine (VLB). S 12,363 bound to tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27636ce2223ac8cec70a2a9c97820dc4
https://pubmed.ncbi.nlm.nih.gov/1551175
https://pubmed.ncbi.nlm.nih.gov/1551175
Autor:
Jean A. Boutin, Corinne Schaeffer, Patrick Hautefaye, Alain Pierré, Claude Cudennec, Gilbert Lavielle
Publikováno v:
Journal of medicinal chemistry. 34(7)
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O4-deacetyl-VLB azide. All of the new products studied were capabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f3e41cba7d43dd9f03b26532bb5879
https://pubmed.ncbi.nlm.nih.gov/2066973
https://pubmed.ncbi.nlm.nih.gov/2066973