Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Patrick H. Thibodeau"'
Autor:
Allison L. Haas, Anna C. Zemke, Jeffrey A. Melvin, Catherine R. Armbruster, Matthew R. Hendricks, John Moore, Seyed Mehdi Nouraie, Patrick H. Thibodeau, Stella E. Lee, Jennifer M. Bomberger
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112270- (2023)
Summary: The cystic fibrosis (CF) respiratory tract harbors pathogenic bacteria that cause life-threatening chronic infections. Of these, Pseudomonas aeruginosa becomes increasingly dominant with age and is associated with worsening lung function and
Externí odkaz:
https://doaj.org/article/d50ebee9b83744a1b83baf06756823ac
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138419 (2015)
The serralysin family of bacterial metalloproteases is associated with virulence in multiple modes of infection. These extracellular proteases are members of the Repeats-in-ToXin (RTX) family of toxins and virulence factors, which mediated virulence
Externí odkaz:
https://doaj.org/article/87cb7297f4994fff8e52a6209b200df0
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100313 (2014)
The serralysin family of metalloproteases is associated with the virulence of multiple gram-negative human pathogens, including Pseudomonas aeruginosa and Serratia marcescens. The serralysin proteases share highly conserved catalytic domains and show
Externí odkaz:
https://doaj.org/article/3f8c0dd6c8574deaaa5cbda05e5a8274
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97360 (2014)
Mutations in the ABCC6 ABC-transporter are causative of pseudoxanthoma elasticum (PXE). The loss of functional ABCC6 protein in the basolateral membrane of the kidney and liver is putatively associated with altered secretion of a circulatory factor.
Externí odkaz:
https://doaj.org/article/8dec23f14102407cb2f6f90805f48ff5
Publikováno v:
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f68cb14d20cd53a4a1cdf423beae137
https://doi.org/10.1007/978-3-030-55454-5_22
https://doi.org/10.1007/978-3-030-55454-5_22
Publikováno v:
Physiology in Health and Disease ISBN: 9783030527792
Seminal structural and biochemical studies demonstrated that proteins are organized by specific structural elements and that the information necessary to form these ordered structures is encoded in the polypeptide chain. Questions related to the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4869c96a35b5e3eeb53afdc6a3eeef33
https://doi.org/10.1007/978-3-030-52780-8_6
https://doi.org/10.1007/978-3-030-52780-8_6
Autor:
Patrick H. Thibodeau, Yanchao Ran
Publikováno v:
Journal of Biological Chemistry. 292:1559-1572
ABC transporters are polytopic membrane proteins that utilize ATP binding and hydrolysis to facilitate transport across biological membranes. Forty-eight human ABC transporters have been identified in the genome, and the majority of these are linked
Publikováno v:
The Journal of biological chemistry. 293(41)
Mutations in ABC subfamily C member 6 (ABCC6) transporter are associated with pseudoxanthoma elasticum (PXE), a disease resulting in ectopic mineralization and affecting multiple tissues. A growing number of mutations have been identified in individu
Autor:
Hardik J. Patel, Jeffrey L. Brodsky, Patrick H. Thibodeau, Gabriela Chiosis, Patrick G. Needham
Publikováno v:
Journal of Molecular Biology. 427:2948-2965
The major cytoplasmic Hsp70 chaperones in the yeast Saccharomyces cerevisiae are the Ssa proteins, and much of our understanding of Hsp70 biology has emerged from studying ssa mutant strains. For example, Ssa1 catalyzes multiple cellular functions, i