Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Patrick H O'Farrell"'
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000891 (2020)
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. A threshold N/C has been widely proposed to activate z
Externí odkaz:
https://doaj.org/article/5bf733b42e744183bf4451ede272fc4f
Autor:
Charles A Seller, Patrick H O'Farrell
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2005687 (2018)
In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this s
Externí odkaz:
https://doaj.org/article/ed0533bafc6944e0bbb04bef6305c135
Autor:
Hansong Ma, Patrick H O'Farrell
Publikováno v:
eLife, Vol 4 (2015)
Homologous recombination is widespread and catalyzes evolution. Nonetheless, its existence in animal mitochondrial DNA is questioned. We designed selections for recombination between co-resident mitochondrial genomes in various heteroplasmic Drosophi
Externí odkaz:
https://doaj.org/article/07369606c61046c988aba76e4153a663
Publikováno v:
PLoS Biology, Vol 4, Iss 1, p e4 (2006)
Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster S2 cells as a model system to study the phagocytosis of Candida albicans, the major fungal pathogen of humans, by screening an RNAi library representing 7,2
Externí odkaz:
https://doaj.org/article/9eb4411e59924036bc4130f32f3a378c
Autor:
Edan Foley, Patrick H O'Farrell
Publikováno v:
PLoS Biology, Vol 2, Iss 8, p E203 (2004)
The innate immune system is ancient and highly conserved. It is the first line of defense and the only recognizable immune system in the vast majority of metazoans. Signaling events that convert pathogen detection into a defense response are central
Externí odkaz:
https://doaj.org/article/9f5bea5bb7ba4cac965b1274e5e12cec
Autor:
Chun-Yi Cho, Patrick H. O’Farrell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized. It is commonly assumed that recruite
Externí odkaz:
https://doaj.org/article/bc36d92fb1644f4d8846d4c05411c353
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1381-1389 (2017)
For hundreds of years, biologists have studied accessible organisms such as garden peas, sea urchins collected at low tide, newt eggs, and flies circling rotten fruit. These organisms help us to understand the world around us, attracting and inspirin
Externí odkaz:
https://doaj.org/article/8cb9b4eaaa5d430a995436f5e44beb81
Autor:
Chun-Yi Cho, Patrick H. O’Farrell
Eukaryotic transcription begins with the binding of transcription factors (TFs), which promotes the subsequent recruitment of coactivators and pre-initiation complexes. It is commonly assumed that these factors eventually co-reside in a higher-order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed7fa8b4d326aad8ddf411f7ed14ffb9
https://doi.org/10.1101/2022.11.08.515694
https://doi.org/10.1101/2022.11.08.515694
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(31)
Unknown processes promote the accumulation of mitochondrial DNA (mtDNA) mutations during aging. Accumulation of defective mitochondrial genomes is thought to promote the progression of heteroplasmic mitochondrial diseases and degenerative changes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef56b7a7a08714a114e0d2058ef8340
https://pubmed.ncbi.nlm.nih.gov/35881807
https://pubmed.ncbi.nlm.nih.gov/35881807
Publikováno v:
Proceedings of the National Academy of Sciences. 119
In the metazoan S phase, coordinated firing of clusters of origins replicates different parts of the genome in a temporal program. Despite advances, neither the mechanism controlling timing nor that coordinating firing of multiple origins is fully un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088bd6c8aa94ad0fae61191ed6f1fb1a
https://doi.org/10.1073/pnas.2200780119
https://doi.org/10.1073/pnas.2200780119