Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Patrick H Maxwell"'
Autor:
Thomas M Connor, Simon Hoer, Andrew Mallett, Daniel P Gale, Aurora Gomez-Duran, Viktor Posse, Robin Antrobus, Pablo Moreno, Marco Sciacovelli, Christian Frezza, Jennifer Duff, Neil S Sheerin, John A Sayer, Margaret Ashcroft, Michael S Wiesener, Gavin Hudson, Claes M Gustafsson, Patrick F Chinnery, Patrick H Maxwell
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006620 (2017)
Tubulointerstitial kidney disease is an important cause of progressive renal failure whose aetiology is incompletely understood. We analysed a large pedigree with maternally inherited tubulointerstitial kidney disease and identified a homoplasmic sub
Externí odkaz:
https://doaj.org/article/6685dd0c725b4fedbc65cf57e4a7ebde
Autor:
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Höhne, Linus A Völker, Thomas Benzing, Patrick H Maxwell, Daniel P Gale, Mathias Gorski, Carsten Böger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174274 (2017)
BACKGROUND:Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible development for a sub
Externí odkaz:
https://doaj.org/article/4982e92e8e3548db842cd64fd672e4a6
Autor:
Bo Meng, Na Zhao, Petra Mlcochova, Isabella A.T.M. Ferreira, Brian M. Ortmann, Tanja Davis, Niek Wit, Jan Rehwinkel, Simon Cook, Patrick H. Maxwell, James A. Nathan, Ravindra K. Gupta
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114471- (2024)
Summary: Low-oxygen conditions (hypoxia) have been associated primarily with cell-cycle arrest in dividing cells. Macrophages are typically quiescent in G0 but can proliferate in response to tissue signals. Here we show that hypoxia (1% oxygen tensio
Externí odkaz:
https://doaj.org/article/eadb2615d1c64a0997c73b03a036fcb1
Autor:
Thomas M F Connor, D Deren Oygar, Daniel P Gale, Retha Steenkamp, Dorothea Nitsch, Guy H Neild, Patrick H Maxwell
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54394 (2013)
BACKGROUND:This is the first report of the incidence and causes of end-stage renal disease (ESRD) of the Turkish-Cypriot population in Northern Cyprus. METHODS:Data were collected over eight consecutive years (2004-2011) from all those starting renal
Externí odkaz:
https://doaj.org/article/3f2823394f6542bfae541d1bf0cf7a05
Autor:
Konstantinos Voskarides, Panayiota Demosthenous, Louiza Papazachariou, Maria Arsali, Yiannis Athanasiou, Michalis Zavros, Kostas Stylianou, Dimitris Xydakis, Eugenios Daphnis, Daniel P Gale, Patrick H Maxwell, Avraam Elia, Cristian Pattaro, Alkis Pierides, Constantinos Deltas
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57925 (2013)
Familial hematuria (FH) is explained by at least four different genes (see below). About 50% of patients develop late proteinuria and chronic kidney disease (CKD). We hypothesized that MYH9/APOL1, two closely linked genes associated with CKD, may be
Externí odkaz:
https://doaj.org/article/7055c818119043ffaada19dbb738d3b8
Autor:
Fredrik Hedborg, Reiner Fischer-Colbrie, Nurtena Ostlin, Bengt Sandstedt, Maxine G B Tran, Patrick H Maxwell
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequently proceed
Externí odkaz:
https://doaj.org/article/0e78895037dc4ba782d74124a303d448
Autor:
Freya M Mowat, Ulrich F O Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James W B Bainbridge
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11103 (2010)
Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse range of
Externí odkaz:
https://doaj.org/article/2c62aac77b2e4cd79c86b579d4b6a3b7
Autor:
Melanie Volke, Daniel P Gale, Ulrike Maegdefrau, Gunnar Schley, Bernd Klanke, Anja-Katrin Bosserhoff, Patrick H Maxwell, Kai-Uwe Eckardt, Christina Warnecke
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7875 (2009)
Hepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores. Hypoxia and chemical stabilizers of the hypoxia-inducible transcription factor (HIF
Externí odkaz:
https://doaj.org/article/625d2233eb834d2a8b56d2ae0a7e449c
Autor:
Thomas G Smith, Jerome T Brooks, George M Balanos, Terence R Lappin, D Mark Layton, Dawn L Leedham, Chun Liu, Patrick H Maxwell, Mary F McMullin, Christopher J McNamara, Melanie J Percy, Christopher W Pugh, Peter J Ratcliffe, Nick P Talbot, Marilyn Treacy, Peter A Robbins
Publikováno v:
PLoS Medicine, Vol 3, Iss 7, p e290 (2006)
BackgroundThe von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to hypoxia, yet insights into its role in system
Externí odkaz:
https://doaj.org/article/52c8f8c7977a47c5b133c24f88912721
Autor:
Patrick J. Pollard, Ian Tomlinson, Mona El-Bahrawy, Lauri Aaltonen, Virpi Launonen, Michael I. Kotlikoff, Maria Flavia Di Renzo, Chiara Bardella, Barbara Costa, Christopher W. Pugh, Richard Poulsom, Gordon Stamp, Patrick H. Maxwell, Emanuela Volpi, Mohammed Yusuf, Bradley Spencer-Dene, John Griffiths, Helen Troy, Deepa Shukla, Kimberley Howarth, Melroy Miranda, Emine Hatipoglu, Emma Nye, Heli Lehtonen, Sakari Vanharanta, Phil East, Yuen-Li Chung, Violetta Steeples, Julie Adam, Linda O'Flaherty, Houman Ashrafian
Supplementary Figure 2 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63279c06787dcbb711a6788a4f91c1ac
https://doi.org/10.1158/0008-5472.22385853
https://doi.org/10.1158/0008-5472.22385853
