Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Patrick H, O'Farrell"'
Autor:
Chun-Yi Cho, Patrick H. O’Farrell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized. It is commonly assumed that recruite
Externí odkaz:
https://doaj.org/article/bc36d92fb1644f4d8846d4c05411c353
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000891 (2020)
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to cytoplasm (N/C) increases. A threshold N/C has been widely proposed to activate z
Externí odkaz:
https://doaj.org/article/5bf733b42e744183bf4451ede272fc4f
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 12, Pp 1381-1389 (2017)
For hundreds of years, biologists have studied accessible organisms such as garden peas, sea urchins collected at low tide, newt eggs, and flies circling rotten fruit. These organisms help us to understand the world around us, attracting and inspirin
Externí odkaz:
https://doaj.org/article/8cb9b4eaaa5d430a995436f5e44beb81
Autor:
Charles A Seller, Patrick H O'Farrell
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2005687 (2018)
In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this s
Externí odkaz:
https://doaj.org/article/ed0533bafc6944e0bbb04bef6305c135
Autor:
Chun-Yi Cho, Patrick H. O’Farrell
Eukaryotic transcription begins with the binding of transcription factors (TFs), which promotes the subsequent recruitment of coactivators and pre-initiation complexes. It is commonly assumed that these factors eventually co-reside in a higher-order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed7fa8b4d326aad8ddf411f7ed14ffb9
https://doi.org/10.1101/2022.11.08.515694
https://doi.org/10.1101/2022.11.08.515694
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(31)
Unknown processes promote the accumulation of mitochondrial DNA (mtDNA) mutations during aging. Accumulation of defective mitochondrial genomes is thought to promote the progression of heteroplasmic mitochondrial diseases and degenerative changes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef56b7a7a08714a114e0d2058ef8340
https://pubmed.ncbi.nlm.nih.gov/35881807
https://pubmed.ncbi.nlm.nih.gov/35881807
Publikováno v:
Proceedings of the National Academy of Sciences. 119
In the metazoan S phase, coordinated firing of clusters of origins replicates different parts of the genome in a temporal program. Despite advances, neither the mechanism controlling timing nor that coordinating firing of multiple origins is fully un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088bd6c8aa94ad0fae61191ed6f1fb1a
https://doi.org/10.1073/pnas.2200780119
https://doi.org/10.1073/pnas.2200780119
Unknown processes promote accumulation of mitochondrial DNA mutations during aging. Accumulation of defective mitochondrial genomes is thought to promote progression of heteroplasmic mitochondrial diseases and degenerative changes with natural aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::082802825d8dbf79a3c16b326ad8de12
https://doi.org/10.1101/2022.01.18.476860
https://doi.org/10.1101/2022.01.18.476860
SUMMARYCollisions between transcribing RNA polymerases and DNA replication forks are disruptive. The threat of collisions is particularly acute during the rapid early embryonic cell cycles of Drosophila when S phase occupies the entirety of interphas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a76fd3ec9bc7954781b6b5b455d06a8
https://doi.org/10.1101/2022.01.04.474810
https://doi.org/10.1101/2022.01.04.474810
Publikováno v:
Cell reports. 41(3)
Collisions between transcribing RNA polymerases and DNA replication forks are disruptive. The threat of collisions is particularly acute during the rapid early embryonic cell cycles of Drosophila when S phase occupies the entirety of interphase. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5cd98ddefbea8e53f7fb7ed94361c7
https://pubmed.ncbi.nlm.nih.gov/36261005
https://pubmed.ncbi.nlm.nih.gov/36261005