Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Patrick Guye"'
Autor:
Patrick Guye, Mohammad R. Ebrahimkhani, Nathan Kipniss, Jeremy J. Velazquez, Eldi Schoenfeld, Samira Kiani, Linda G. Griffith, Ron Weiss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex ti
Externí odkaz:
https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7
Autor:
Volker Busskamp, Nathan E Lewis, Patrick Guye, Alex HM Ng, Seth L Shipman, Susan M Byrne, Neville E Sanjana, Jernej Murn, Yinqing Li, Shangzhong Li, Michael Stadler, Ron Weiss, George M Church
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 11, Pp n/a-n/a (2014)
Abstract Advances in cellular reprogramming and stem cell differentiation now enable ex vivo studies of human neuronal differentiation. However, it remains challenging to elucidate the underlying regulatory programs because differentiation protocols
Externí odkaz:
https://doaj.org/article/286c8d758b2e4464b99c7cda8cc0b0ab
Autor:
Rusudan Okujava, Patrick Guye, Yun-Yueh Lu, Claudia Mistl, Florine Polus, Muriel Vayssier-Taussat, Cornelia Halin, Antonius G Rolink, Christoph Dehio
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004187 (2014)
Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These effectors may interfere with each other to efficiently control the infection process. Bartonellae are Gram-negative, facultative intracellular bacteria
Externí odkaz:
https://doaj.org/article/dfc71ebe1dfc4046aa5dac5c1cb18c31
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25106 (2011)
The gram-negative, zoonotic pathogen Bartonella henselae (Bhe) translocates seven distinct Bartonella effector proteins (Beps) via the VirB/VirD4 type IV secretion system (T4SS) into human cells, thereby interfering with host cell signaling [1], [2].
Externí odkaz:
https://doaj.org/article/88ba71660c3d48ecaa76976b05cc8b99
Autor:
Michael C Schmid, Florine Scheidegger, Michaela Dehio, Nadège Balmelle-Devaux, Ralf Schulein, Patrick Guye, Cuddapah S Chennakesava, Barbara Biedermann, Christoph Dehio
Publikováno v:
PLoS Pathogens, Vol 2, Iss 11, p e115 (2006)
The modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. The capacity of Bartonella henselae and B. quintana to cause vascular tumor formation in immunocompromised patients is li
Externí odkaz:
https://doaj.org/article/eedc6982d39e45a286df30e989c9759b
Autor:
Tanja Hansen, Laia Tolosa, Jan G. Hengstler, Richard Maclennan, Paul Walker, Rajinder Gupta, Bob van de Water, Florian Caiment, Leroy Elenschneider, Patrick Guye, Bas ter Braak, Sylvia Escher, Jos C. S. Kleinjans, Marcel H. M. van Herwijnen, Wolfgang Moritz, Yannick Schrooders, Tim Brecklinghaus, Ahmed Ghallab, Tine Tricot, Duncan Hauser, Wiebke Albrecht, Marcel Leist, José V. Castell, Catherine M. Verfaillie
Publikováno v:
Archives of Toxicology, 95(2), 573-589. Springer
Archives of toxicology, 95:573-589
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 95:573-589
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
The liver plays an important role in xenobiotic metabolism and represents a primary target for toxic substances. Many different in vitro cell models have been developed in the past decades. In this study, we used RNA-sequencing (RNA-Seq) to analyze t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5986590902ae84f34deb3752761c86b9
Autor:
Witold Wolski, Irina Agarkova, Hans Gmuender, Stefano Gotta, Ugis Sarkans, Ralf Herwig, Adrian Roth, Johannes Schuchhardt, Henrik Cordes, Patrick Guye, Bernd Timmermann, Steven A. Niederer, Jos C. S. Kleinjans, Marcha Verheijen, Jasmine Minguet, Sally J. Deeb, Carla Pluess, Vanessa Baier, Matthias Lienhard, Ivo Bachmann, Jort J. Merken, Alexandra Zerck, Stefan Boerno, Ramona Nudischer, Anne Hersey, Christoph Thiel, Francis Atkinson, Olivia Clayton, Laura Kunz, Lars Kuepfer, Fiona M. I. Hunter, Christopher F. Bauer, Stephane Heymans, Yannick Schrooders, Gal Barel, Nathalie Selevsek, Alex Lewalle, Ralph Schlapbach, Nicolas Bosc, Florian Caiment, Timo Wittenberger, Ines Smit, Bernardo Lino de Oliveira
Publikováno v:
Communications Biology
Communications Biology, 3(1):573. Nature Publishing Group
Communications biology 3, 573 (2020). doi:10.1038/s42003-020-01302-8
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Communications Biology, 3(1):573. Nature Publishing Group
Communications biology 3, 573 (2020). doi:10.1038/s42003-020-01302-8
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized by integrating the molecular activities in networks of interacting proteins. As proof-of-concept we ch
Autor:
Patrick Guye, Henrik Cordes, Madhu Lal-Nag, Jens M. Kelm, Zoe Weydert, Lesley Mathews-Greiner, Christoph Thiel, Marc Ferrer, Lars Küpfer
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(3)
Three-dimensional (3D) cell culture models are thought to mimic the physiological and pharmacological properties of tissues in vivo more accurately than two-dimensional cultures on plastic dishes. For the development of cancer therapies, 3D spheroid
Autor:
Xavier Duportet, Patrick Guye, Yingqing Li, Tharathorn Rimchala, Justin Eyquem, Liliana Wroblewska, Gregory Batt, Julianne Rieders, Ron Weiss
Publikováno v:
Oxford University Press
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (21), pp.12. ⟨10.1093/nar/gku1082⟩
Nucleic Acids Research, 2014, 42 (21), pp.12. ⟨10.1093/nar/gku1082⟩
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (21), pp.12. ⟨10.1093/nar/gku1082⟩
Nucleic Acids Research, 2014, 42 (21), pp.12. ⟨10.1093/nar/gku1082⟩
Mammalian synthetic biology may provide novel therapeutic strategies, help decipher new paths for drug discovery and facilitate synthesis of valuable molecules. Yet, our capacity to genetically program cells is currently hampered by the lack of effic
Publikováno v:
Journal of Hepatology. 68:S356-S357