Výsledky vyhledávání - "Patrick Gubser"

Reference Genes for Expression Studies in Human CD8+ Naïve and Effector Memory T Cells under Resting and Activating Conditions

Autor: Gunhild Unterstab, Renato Paro, Marco Geigges, Christoph Hess, Patrick Gubser, Yannic Lecoultre

Publikováno v: Scientific Reports, 10 (1)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c87d84d6c81a1682da3b24f213df73
https://www.repository.cam.ac.uk/handle/1810/307055

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Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis

Autor: Marco Fischer, Gunhild Unterstab, Jasmin Grählert, Ursula Sauder, Rebekah Steiner, Glenn R. Bantug, Christoph Hess, Patrick Gubser, Gideon Hoenger, Leyla Develioglu, Anne-Valérie Burgener, Sarah Dimeloe, Maria L. Balmer

Publikováno v: European Journal of Immunology. 48:1632-1643

The role of mitochondrial biogenesis during naive to effector differentiation of CD8+ T cells remains ill explored. In this study, we describe a critical role for early mitochondrial biogenesis in supporting cytokine production of nascent activated h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb584e1361c58859fb56f0e2b3b362eb
https://doi.org/10.1002/eji.201747443

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Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4

Autor: Patrick Gubser, Corina Frick, Sarah Dimeloe, Yannic Lecoultre, Alfred Zippelius, Anja Langenkamp, Glenn R. Bantug, Leyla Develioglu, Daniela S. Thommen, Jordan Loeliger, Marco Fischer, Christoph Hess, Florian Marquardsen

Publikováno v: Science signaling. 12(599)

Transforming growth factor-β (TGF-β) is produced by tumors, and increased amounts of this cytokine in the tumor microenvironment and serum are associated with poor patient survival. TGF-β-mediated suppression of antitumor T cell responses contribu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239b422f667d3d139c3e24fa3be45074
https://pubmed.ncbi.nlm.nih.gov/31530731

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Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis

Autor: Patrick Gubser, Leyla Razik, Glenn R. Bantug, Sarah Dimeloe, Anja Langenkamp, Morgane Ravon, Marco Fischer, Corina Frick, Christoph Hess

Publikováno v: European Journal of Immunology. 44:3614-3620

ATP-binding cassette (ABC) transporters, including ABC-transporter B1 (ABCB1), extrude drugs, metabolites, and other compounds (such as mitotracker green (MTG)) from cells. Susceptibility of CD4(+) regulatory T (Treg) cells to the ABCB1-substrate cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03b3d10c7aa9a7dbbe827efda5d9d01d
https://doi.org/10.1002/eji.201444879

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Epstein-Barr Virus Negativity among Individuals Older than 60 Years Is Associated with HLA-C and HLA-Bw4 Variants and Tonsillectomy

Autor: Patrick Gubser, Jörg Sigle, Martin Stern, Andreas Buser, Olivier Gasser, Christoph Hess, Hans H. Hirsch, Bojana Durovic

Epstein-Barr virus (EBV) infects ∼95% of the adult population. The factors that confer protection in the remaining ∼5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0920b30541f7d76193cce6836694811c
https://europepmc.org/articles/PMC3648112/

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Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

Autor: Leyla Razik, Sarah Dimeloe, Marco Fischer, Glenn R. Bantug, Christoph Hess, Gideon Hoenger, Patrick Gubser, Annaïse Jauch, Bojana Durovic

Publikováno v: Nature Immunology

Antigen-experienced memory T cells acquire effector function with innate-like kinetics; however, the metabolic requirements of these cells are unknown. Here we show that rapid interferon-γ (IFN-γ) production of effector memory (EM) CD8(+) T cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f174189889e45a6ee75e4b6baa30f8
https://pubmed.ncbi.nlm.nih.gov/23955661

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Giant cell arteritis- a changing entity

Autor: Friederike Kesten, Katharina Glatz, Markus Aschwanden, Thomas Daikeler, Patrick Gubser, Christoph Hess

Publikováno v: Swiss Medical Weekly.

Giant cell arteritis (GCA) is the most common of the vasculitis syndromes and, being a disease of the elderly, its incidence is increasing with the general ageing of the population. GCA is most feared for its early complications, namely blindness and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5354ba21fc4427817e8ee9bd385a645b
https://doi.org/10.4414/smw.2011.13272

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A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells

Autor: Andrea Steinhuber, Petra S. Eisele, Christoph Handschin, Gabriela Zenhaeusern, Patrick Gubser, Andrej Trampuz, Andrew D. Luster, Olivier Gasser, Christoph Hess

T cells move randomly (“random-walk”), a characteristic thought to be integral to their function. Using migration assays and time-lapse microscopy, we found that CD8+ T cells lacking the lymph node homing receptors CCR7 and CD62L migrate more eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24da26250df993615730db485a609b18
https://edoc.unibas.ch/5035/

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