Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models

Autor: Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, Olivier Duclos, Sergio Mallart, Ross Bathgate, Philip Janiak

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by its short half-life and the need for intravenous administration limiting its use to intensive care units. A multi

Externí odkaz: https://doaj.org/article/9680bc4f067244f5859525deb060514b

A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P 1 agonists

Autor: Patrick Grailhe, Philippe Beauverger, Asma Boutarfa-Madec, Philip Janiak, Ashfaq Parkar

Publikováno v: FEBS Open Bio, Vol 10, Iss 10, Pp 2010-2020 (2020)

Sphingosine-1 phosphate receptor-1 (S1P1 ) activation maintains endothelial barrier integrity, whereas S1P1 desensitization induces peripheral blood lymphopenia. The latter is exploited in the approval and/or late-stage development of receptor-desens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50fa47aff59507ff66a75b08125b86f
https://doi.org/10.1002/2211-5463.12951

A G protein–biased S1P 1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

Autor: Philip Janiak, Dieter Kadereit, Marie-Claire Philippo, Laurent Gouraud, Anthony J. Muslin, Dominique Caillaud, Paulus Wohlfart, Jean-Pierre Bidouard, Véronique Briand, Bruno Poirier, Ashfaq Parkar, Marc Trellu, Patrick Grailhe, Matthias Schäfer

Publikováno v: Science Signaling. 13

Endothelial dysfunction is a hallmark of tissue injury and is believed to initiate the development of vascular diseases. Sphingosine-1 phosphate receptor-1 (S1P1) plays fundamental physiological roles in endothelial function and lymphocyte homing. Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6a8bf60e17d484becdb54212c81c05d
https://doi.org/10.1126/scisignal.aax8050

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.

Autor: Illiano, Stephane^1,2 (AUTHOR) stephane.illiano@irsn.fr, Poirier, Bruno¹ (AUTHOR), Minoletti, Claire³ (AUTHOR), Pasquier, Olivier⁴ (AUTHOR), Riva, Laurence¹ (AUTHOR), Chenede, Xavier¹ (AUTHOR), Menguy, Isabelle³ (AUTHOR), Guillotel, Michel¹ (AUTHOR), Prigent, Philippe¹ (AUTHOR), Le Claire, Stéphane¹ (AUTHOR), Gillot, Florence¹ (AUTHOR), Thill, Gilbert⁵ (AUTHOR), Lo Presti, François¹ (AUTHOR), Corbier, Alain¹ (AUTHOR), Le Bail, Jean-Christophe¹ (AUTHOR), Grailhe, Patrick¹ (AUTHOR), Monteagudo, Edith⁶ (AUTHOR), Ingenito, Raffaele⁶ (AUTHOR), Bianchi, Elisabetta⁶ (AUTHOR), Philippo, Christophe¹ (AUTHOR)

Publikováno v: Scientific Reports. 11/28/2022, Vol. 12 Issue 1, p1-17. 17p.

A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.

Autor: Poirier, Bruno, Briand, Veronique, Kadereit, Dieter, Schäfer, Matthias, Wohlfart, Paulus, Philippo, Marie-Claire, Caillaud, Dominique, Gouraud, Laurent, Grailhe, Patrick, Bidouard, Jean-Pierre, Trellu, Marc, Muslin, Anthony J., Janiak, Philip, Parkar, Ashfaq A.

Publikováno v: Science Signaling; 6/2/2020, Vol. 13 Issue 634, p1-13, 13p