Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Patrick Goegan"'
Autor:
Ngoc Q. Vuong, Dalibor Breznan, Patrick Goegan, Julie S. O’Brien, Andrew Williams, Subramanian Karthikeyan, Premkumari Kumarathasan, Renaud Vincent
Publikováno v:
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-19 (2017)
Abstract Background Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition is complex and variable due to source contribution and atmospheric transformation. In this study, we used an in vitro toxicoproteomic appro
Externí odkaz:
https://doaj.org/article/e6f2b9510afd4826b89d011e9fb5c621
Human lung epithelial cell A549 proteome data after treatment with titanium dioxide and carbon black
Autor:
Ngoc Q. Vuong, Patrick Goegan, Susantha Mohottalage, Dalibor Breznan, Marianne Ariganello, Andrew Williams, Fred Elisma, Subramanian Karthikeyan, Renaud Vincent, Premkumari Kumarathasan
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 687-691 (2016)
Here, we have described the dataset relevant to the A549 cellular proteome changes after exposure to either titanium dioxide or carbon black particles as compared to the non-exposed controls, “Proteomic changes in human lung epithelial cells (A549)
Externí odkaz:
https://doaj.org/article/485c9a7d9919488282861892b5211465
Autor:
Renaud Vincent, Premkumari Kumarathasan, Patrick Goegan, Stephen G. Bjarnason, Josée Guénette, Subramanian Karthikeyan, Errol M. Thomson, Ian Y. Adamson, William P. Watkinson, Bruno Battistini, Frederick J. Miller
Publikováno v:
Chemosphere. 296
Short-term increases in particulate matter (PM) are associated with heightened morbidity and mortality from cardiovascular causes. Inhalation of PM is known to increase endothelin (ET)-1 levels. Yet, less is known about particle composition-related c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d7535fa1e3efce9004415de500aa3
https://pubmed.ncbi.nlm.nih.gov/35157883
https://pubmed.ncbi.nlm.nih.gov/35157883
Autor:
Francesco De Rose, Patrick Goegan, Andrew Williams, Errol M. Thomson, Premkumari Kumarathasan, Subramanian Karthikeyan, Julie S. O’Brien, Dalibor Breznan, Renaud Vincent, Ngoc Q. Vuong
Publikováno v:
Journal of Applied Toxicology. 37:721-731
In this study, we used cytotoxicity assays, proteomic and gene expression analyses to examine the difference in response of A549 cells to two silica particles that differ in physical properties, namely cristobalite (CR) and α-quartz (Min-U-Sil 5, MI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e3e6291af7978340ff3ba2166e70d4
https://doi.org/10.1002/jat.3420
https://doi.org/10.1002/jat.3420
Autor:
Renaud Vincent, Andrew Williams, Dalibor Breznan, Julie S. O’Brien, Ngoc Q. Vuong, Patrick Goegan, Premkumari Kumarathasan, Subramanian Karthikeyan
Publikováno v:
Particle and Fibre Toxicology
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-19 (2017)
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-19 (2017)
Background Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition is complex and variable due to source contribution and atmospheric transformation. In this study, we used an in vitro toxicoproteomic approach to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f98f94493a39ceaa080f72b05df9e9d
http://europepmc.org/articles/PMC5625787
http://europepmc.org/articles/PMC5625787
Autor:
Vinita Chauhan, Prem Kumarathasan, Dalibor Breznan, Subramanian Karthikeyan, Sabit Cakmak, Renaud Vincent, Denis Nadeau, Jeffrey R. Brook, Patrick Goegan
Publikováno v:
Toxicology in Vitro. 27:1287-1297
We examined the utility of respiratory burst measurements in alveolar macrophages to assess adverse cellular changes following exposure to urban particles. Cells were obtained by bronchioalveolar lavage of Fisher 344 rats and exposed (0-100 μg/well)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aa092e7317ea4e2da978c276cd1fb
https://doi.org/10.1016/j.tiv.2013.02.014
https://doi.org/10.1016/j.tiv.2013.02.014
Autor:
Josée Guénette, James D. Crapo, R. J. Mason, Ian Y. R. Adamson, A. Yagminas, Premkumari Kumarathasan, Patrick Goegan, Renaud Vincent, Erica Blais
Publikováno v:
International Journal of Toxicology. 24:59-67
Tumor necrosis factor (TNF)- α, a cytokine present in inflammed lungs, is known to mediate some of the adverse effects of ozone and inhaled particles. The authors evaluated transgenic mice with constitutive pulmonary expression of TNF- αunder trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9716e0dc6047f858b37903b0a664630e
https://doi.org/10.1080/10915810590921379
https://doi.org/10.1080/10915810590921379
Publikováno v:
Analytical Biochemistry. 299:37-44
A high-performance liquid chromatographic method with fluorescence detection was developed to simultaneously analyze endothelins, a class of vasoactive peptides, in plasma samples. Sample preparation for HPLC analysis was carried out by initial stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a704917188e9edd92da65bace50eb
https://doi.org/10.1006/abio.2001.5362
https://doi.org/10.1006/abio.2001.5362
Autor:
Mark Stewart, Josée Guénette, Stephen Bjarnason, Ian Y. R. Adamson, Marc Potvin, Léo Bouthillier, Prem Kumarathasan, Renaud Vincent, Patrick Goegan
Publikováno v:
The American Journal of Pathology. 153:1873-1884
We studied acute responses of rat lungs to inhalation of urban particulate matter and ozone. Exposure to particles (40 mg/m 3 for 4 hours; mass median aerodynamic diameter, 4 to 5 μm; Ottawa urban dust, EHC-93), followed by 20 hours in clean air, di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2014d158b2df873fd329197a5f018bf2
https://doi.org/10.1016/s0002-9440(10)65701-x
https://doi.org/10.1016/s0002-9440(10)65701-x
Autor:
Prem Kumarathasan, Richard T. Burnett, Renaud Vincent, Jeffrey R. Brook, Gala Johnson, Léo Bouthillier, Patrick Goegan
Publikováno v:
Scopus-Elsevier
A panel of HepG2-derived cell lines (CAT-Tox [L] assay, Xenometrix), harboring stress genes consisting of a sequence for chloramphenicol acetyltransferase (CAT) under the transcriptional regulation from mammalian promoters and response elements, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49605718513160a8da735b316e44cd8d
https://doi.org/10.1093/toxsci/39.1.18
https://doi.org/10.1093/toxsci/39.1.18