Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patrick Garrouste"'
Autor:
Viktoriia Postupalenko, Léo Marx, David Viertl, Nadège Gsponer, Natalia Gasilova, Thibaut Denoel, Niklaus Schaefer, John O. Prior, Gerrit Hagens, Frédéric Lévy, Patrick Garrouste, Jean-Manuel Segura, Origène Nyanguile
Publikováno v:
Chemical science, vol. 13, no. 14, pp. 3965-3976
Antibodies are an attractive therapeutic modality for cancer treatment as they allow the increase of the treatment response rate and avoid the severe side effects of chemotherapy. Notwithstanding the strong benefit of antibodies, the efficacy of anti
Autor:
Hyunkyung Yu, Nathalie Bellocq, Youngeun Ha, Hyunuk Kim, Yunyeon Kim, Bu-Nam Jeon, Léo Marx, Mathilde Pantin, Hyunjin Yoo, Seungmin Byun, Joo-Yeon Chung, Mi Young Cha, Patrick Garrouste, Frédéric Lévy
Publikováno v:
Cancer Research. 82:1760-1760
Antibody-drug conjugates (ADCs) are considered as promising cancer treatment modalities that combine the selectivity of antibodies and the cytotoxic properties of payloads using chemical linkers. However, despite their success, ADCs still suffer from
Autor:
David Viertl, Jean-Manuel Segura, Margret Schottelius, Patrick Garrouste, John O. Prior, Origene Nyanguile, Mathilde Plantin, Leo Marx, Thibaut Denoël, Frédéric Lévy, Viktoriia Postupalenko, Natalia Gasilova, Alexandre Johanssen, Nadège Gsponer, Niklaus Schaefer, Gerrit Hagens
Publikováno v:
Cancer Research. 81:1304-1304
Clinical development of therapeutic antibodies relies on robust and thorough preclinical evaluation of multiple pharmacodynamic and pharmacokinetic parameters of antibody candidates. While current methods are available for in vitro characterization o
Autor:
Michèle Reboud-Ravaux, Patrick Garrouste, Sames Sicsic, Pascal Dumy, Eve de Rosny, Jean Martinez, Thierry Tonnaire, Macek Pawlowski, Pierre Fulcrand
Publikováno v:
European Journal of Medicinal Chemistry. 33:423-436
We report here the synthesis and activity of HIV protease inhibitors. In the first stage hydrophobic compounds incorporating a ‘carba’ bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in whi
Publikováno v:
Journal of Peptide Science. 4:72-80
(S-2-amino-5-(aminooxy)pentanoic acid (L-homocanaline, HCan), a structural analogue of lysine, contains a reactive alkyloxyamine side chain and is therefore considered to react chemoselectively with carbonyl compounds by forming a kinetically stable
Publikováno v:
Tetrahedron. 53:7231-7236
The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an exa
Autor:
Patrick Garrouste, Marc Mathieu, Pascal Dumy, Gabriele Tuchscherer, Stéphane Peluso, Christian Lehmann, Manfred Mutter, Cristina Peggion, Alain Razaname
Publikováno v:
Angewandte Chemie. 108:1588-1591
Autor:
Marc Mathieu, Stéphane Peluso, Cristina Peggion, Pascal Dumy, Patrick Garrouste, Alain Razaname, Gabriele Tuchscherer, Christian Lehmann, Manfred Mutter
Publikováno v:
Angewandte Chemie International Edition in English. 35:1482-1485
A review with 26 refs. Methodologies for the synthesis of functional TASP compds. are given. [on SciFinder (R)]
Autor:
Patrick Garrouste, J.‐C. Califano, Albert Loffet, Chantal Devin, Jean Martinez, F. Winternitz, Francois Rieunier, Olivier Chaloin, M Llinares, Ana-Christina Lima-Leite, Jean-Alain Fehrentz, Jean Vizavonna, E. Bourdel
Publikováno v:
Tetrahedron Letters. 35:1557-1560
The synthesis of chiral N-protected tetramic acid derivatives which are important precursors of β-hydroxy γ-amino acid under mild conditions is described. Reaction of urethane-N-carboxyanhydrides (UNCAs) with Meldrum's acid in the presence of a ter
Publikováno v:
Tetrahedron Letters. 34:7409-7412
A facile synthesis of a wide variety of N-benzyloxycarbonyl-amino acid-tert-butyl ester derivatives under mild conditions is described. N-protected amino acids were esterified with tert-butyl bromide in dimethylacetamide as solvent, in the presence o