Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Patrick Garidel"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100202- (2023)
To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active compounds (surfactants) are added to protect biologics from denaturation and particle formation. In this context, polysorbate 20 and 80 are the most used de
Externí odkaz:
https://doaj.org/article/6e211d810eab4284acca8633e52ed03c
Autor:
Elena Hipper, Florian Lehmann, Wolfgang Kaiser, Göran Hübner, Julia Buske, Michaela Blech, Dariush Hinderberger, Patrick Garidel
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100155- (2023)
Visible light (400–800 nm) can lead to photooxidation of protein formulations, which might impair protein integrity. However, the relevant mechanism of photooxidation upon visible light exposure is still unclear for therapeutic proteins, since prot
Externí odkaz:
https://doaj.org/article/7cc94d0fe43b4541ae395f6342387dc1
Autor:
Klaus Brandenburg, Raquel Ferrer-Espada, Guillermo Martinez-de-Tejada, Christian Nehls, Satoshi Fukuoka, Karl Mauss, Günther Weindl, Patrick Garidel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15169 (2023)
Sepsis is a life-threatening condition caused by the body’s overwhelming response to an infection, such as pneumonia or urinary tract infection. It occurs when the immune system releases cytokines into the bloodstream, triggering widespread inflamm
Externí odkaz:
https://doaj.org/article/bc2b1d7943cd4f28942adf9bb4b9d566
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2332 (2023)
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality. Oxidation has been
Externí odkaz:
https://doaj.org/article/7becff0f4d95445bbf46386b1f1762a9
Autor:
Judith J. Mittag, Marie-Luise Trutschel, Helen Kruschwitz, Karsten Mäder, Julia Buske, Patrick Garidel
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100123- (2022)
Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical com
Externí odkaz:
https://doaj.org/article/c8534eade61845c5b7faf06baf683dff
Autor:
Luisa Stroppel, Torsten Schultz-Fademrecht, Martin Cebulla, Michaela Blech, Richard J. Marhöfer, Paul M. Selzer, Patrick Garidel
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 563 (2023)
Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is e
Externí odkaz:
https://doaj.org/article/8d498e215cc642b898229db9c9c84504
Autor:
Clemens Möller, Lena Heinbockel, Patrick Garidel, Thomas Gutsmann, Karl Mauss, Günther Weindl, Satoshi Fukuoka, Dominik Loser, Timm Danker, Klaus Brandenburg
Publikováno v:
Microorganisms, Vol 10, Iss 12, p 2412 (2022)
Aspidasept (Pep19-2.5) and its derivative Pep19-4LF (“Aspidasept II”) are anti-infective and anti-inflammatory synthetic polypeptides currently in development for application against a variety of moderate to severe bacterial infections that could
Externí odkaz:
https://doaj.org/article/980ab233bdda43e4bb025cb4bae0eb01
Autor:
Angel J. Castañeda Ruiz, Maryam A. Shetab Boushehri, Tamara Phan, Stefan Carle, Patrick Garidel, Julia Buske, Alf Lamprecht
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2575 (2022)
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports abou
Externí odkaz:
https://doaj.org/article/26eb8014fb0b47a39dabea8f265321b4
Autor:
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavor
Externí odkaz:
https://doaj.org/article/4b709eb7b77347208fd2e1baab40e518
Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 72 (2021)
UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation
Externí odkaz:
https://doaj.org/article/3bfe42c26f814ea6a6cff7acbb295f72