Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Patrick Gammell"'
Autor:
Martin Clynes, Patrick Gammell, John R. W. Masters, Niall Barron, Joanne Keenan, Alex Freeman, Vanesa G. Martinez
Publikováno v:
The Prostate. 72:1193-1199
BACKGROUND Radical prostatectomy cures the majority of men with clinically localized disease, but up to 30% of men relapse with rising serum PSA levels. Stage, Gleason grade, and pre-operative PSA levels are associated with outcome but do not accurat
Autor:
Niall Barron, Mark Melville, Paula Meleady, Martin Clynes, Patrick Gammell, Colin Clarke, Padraig Doolan, Finbarr O'Sullivan, Mark Leonard
Publikováno v:
Journal of Biotechnology. 151:159-165
Improving the rate of recombinant protein production in Chinese hamster ovary (CHO) cells is an important consideration in controlling the cost of biopharmaceuticals. We present the first predictive model of productivity in CHO bioprocess culture bas
Autor:
Linda Francullo, Martin S. Sinacore, Mark Melville, Paula Meleady, Timothy S. Charlebois, Padraig Doolan, Michael Henry, Mark Leonard, Martin Clynes, Patrick Gammell
Publikováno v:
PROTEOMICS. 8:2611-2624
Chinese hamster ovary (CHO) cells are widely used for the production of recombinant protein biopharmaceuticals. The purpose of this study was to investigate differences in the proteome of CHO DUKX cells expressing recombinant human bone morphogenetic
Autor:
Robert O'Connor, Eoin Ryan, Helena Joyce, Jai Prakash Mehta, Vanesa G. Martinez, Lorraine O'Driscoll, Elaine Kenny, Susan Kennedy, Martin Clynes, Patrick Gammell, John Crown, Padraig Doolan
Publikováno v:
Breast Cancer Research and Treatment. 110:521-530
The complex role of drug metabolism-related enzymes and their possible influence in cancer development, treatment and outcome has not yet been completely elucidated. There is evidence that these enzymes can activate certain environmental procarcinoge
Publikováno v:
Cytotechnology. 51:29-37
DeltaFerrin(TM), a yeast-derived recombinant human transferrin produced by Delta Biotechnology Ltd. (Nottingham UK), was found to be a suitable replacement for holo human transferrin in serum-free culture media of the MDCK cell line (chosen because o
Autor:
Y Liang, Mary Heenan, Joanne Keenan, Sharon A. Glynn, Rosemary O'Connor, Martin Clynes, Patrick Gammell
Publikováno v:
British Journal of Cancer
Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is charact
Publikováno v:
Cytotechnology. 41:11-21
Autoimmune destruction of β cells in the pancreas leads to type I, or insulin dependent diabetes mellitus (IDDM), through the loss of endogenous insulin production capacity. This paper describes an attempt to generate ‘artificial’β cells using
Autor:
George Boras, Jose Gregorio Ramirez, Patrick Gammell, Jeffrey Galvin, Keith A. Britt, Gregory Naugle, Esther Presente, David Kolwyck, Joseph Nti-Gyabaah
Publikováno v:
Biotechnology progress. 30(5)
Simethicone emulsion is used to regulate foaming in cell culture operations in biopharmaceutical processes. It is also a potential source of endotoxin contamination. The inactivation of endotoxins in dilute simethicone emulsions was assessed as a fun
Autor:
Enda, Moran, Patrick, Gammell
Publikováno v:
Advances in biochemical engineering/biotechnology. 139
Product lifecycle management refers to the oversight process and activities carried out to fully realize the commercial potential and value of a product in the marketplace. It is typical for many changes to be introduced to the production processes a
Publikováno v:
Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 ISBN: 9789400708839
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. They have been implicated in diverse cellular functions and are currently the subject of considerable interest in all aspects of cell biology. They are highly conserved evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::669e8651f6080ea6ef21d1d05a77a087
https://doi.org/10.1007/978-94-007-0884-6_1
https://doi.org/10.1007/978-94-007-0884-6_1