Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Patrick G. Steel"'
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania, the etiological agent of the
Externí odkaz:
https://doaj.org/article/078fbf832e174ac7949d4e5f04c19d91
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America. Currently, there is no available vaccine, and c
Externí odkaz:
https://doaj.org/article/d883a9501ec347288f51d5b76948cd5e
Autor:
Exequiel O.J. Porta, Patrick G. Steel
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 5, Iss , Pp 100164- (2023)
Activity-based protein profiling (ABPP) is a chemoproteomic technology that employs small chemical probes to directly interrogate protein function within complex proteomes. Since its initial application almost 25 years ago, ABPP has proven to be a po
Externí odkaz:
https://doaj.org/article/7f893ac6451844d78045767a48f8ecb1
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of act
Externí odkaz:
https://doaj.org/article/29d3af68c270402ebd30e752d82407ba
Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function
Publikováno v:
Plant Direct, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Synthesized small molecules are useful as tools to investigate hormonal signaling involved in plant growth and development. They are also important as agrochemicals to promote beneficial properties of crops in the field. We describe here the
Externí odkaz:
https://doaj.org/article/4b186f15f772406897f7df63c65c02df
Autor:
Alistair K. Brown, Ahmed K. B. Aljohani, Jason H. Gill, Patrick G. Steel, Jonathan D. Sellars
Publikováno v:
Molecules, Vol 24, Iss 4, p 811 (2019)
Discovery and development of new therapeutic options for the treatment of Mycobacterium tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of this disease and the efficacy and cost limitations associated with c
Externí odkaz:
https://doaj.org/article/38ab9c03995546de90e93ad297aa20cd
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 2, Iss 1, p 9 (2006)
The nitro oxanorbornene adduct derived from the Diels-Alder reaction of ethyl (E)-3-nitroacrylate and furan provides a versatile template for the stereoselective synthesis of hydroxylated derivatives of 2-aminocyclohexanecarboxylic acid (ACHC).
Externí odkaz:
https://doaj.org/article/5545ef957fc440b8b16109edb3a0917b
Publikováno v:
European Journal of Organic Chemistry, 2022, Vol.2022(47) [Peer Reviewed Journal]
The iridium catalysed C−H borylation of polyfluorinated arenes and heteroarenes occurs rapidly and efficiently. As with other borylation reactions, whilst steric parameters dominate, an underlying electronic influence on reaction selectivity can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb28e69ca3319cdc893c7f97414d14
https://doi.org/10.1002/ejoc.202201005
https://doi.org/10.1002/ejoc.202201005
Autor:
Amy V. Hall, Isobel E. F. Gostick, Dmitry S. Yufit, Gloria Y. Marchant, Preyanthiny Kirubakaran, Shadrack J. Madu, Mingzhong Li, Patrick G. Steel, Jonathan W. Steed
Publikováno v:
Crystal growth & design, 2022, Vol.22(10), pp.6262-6266 [Peer Reviewed Journal]
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Open access article open access article Miltefosine is a repurposed anticancer drug and currently the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307284f421656e488ff2d82a703cc3e5
https://hdl.handle.net/2086/22214
https://hdl.handle.net/2086/22214