Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Patrick G. Steel"'
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania, the etiological agent of the
Externí odkaz:
https://doaj.org/article/078fbf832e174ac7949d4e5f04c19d91
Autor:
Nailma S A Dos Santos, Carlos F Estevez-Castro, Juan P Macedo, Daniela F Chame, Thiago Castro-Gomes, Mariana Santos-Cardoso, Gabriela A Burle-Caldas, Courtney N Covington, Patrick G Steel, Terry K Smith, Paul W Denny, Santuza M R Teixeira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011646 (2023)
Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a c
Externí odkaz:
https://doaj.org/article/59bb370ad8bb491b8ca365e30536662c
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America. Currently, there is no available vaccine, and c
Externí odkaz:
https://doaj.org/article/d883a9501ec347288f51d5b76948cd5e
Autor:
Exequiel O.J. Porta, Patrick G. Steel
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 5, Iss , Pp 100164- (2023)
Activity-based protein profiling (ABPP) is a chemoproteomic technology that employs small chemical probes to directly interrogate protein function within complex proteomes. Since its initial application almost 25 years ago, ABPP has proven to be a po
Externí odkaz:
https://doaj.org/article/7f893ac6451844d78045767a48f8ecb1
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of act
Externí odkaz:
https://doaj.org/article/29d3af68c270402ebd30e752d82407ba
Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function
Publikováno v:
Plant Direct, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Synthesized small molecules are useful as tools to investigate hormonal signaling involved in plant growth and development. They are also important as agrochemicals to promote beneficial properties of crops in the field. We describe here the
Externí odkaz:
https://doaj.org/article/4b186f15f772406897f7df63c65c02df
Autor:
Douglas O Escrivani, Rebecca L Charlton, Marjolly B Caruso, Gabriela A Burle-Caldas, Maria Paula G Borsodi, Russolina B Zingali, Natalia Arruda-Costa, Marcos V Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W Denny, Bartira Rossi-Bergmann, Patrick G Steel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009951 (2021)
With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-met
Externí odkaz:
https://doaj.org/article/97dcebeea4914662b9ca60f477d72118
Autor:
Elizabeth C Pinneh, Rhea Stoppel, Heather Knight, Marc R Knight, Patrick G Steel, Paul W Denny
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217087 (2019)
This research was undertaken to investigate the global role of the plant inositol phosphorylceramide synthase (IPCS), a non-mammalian enzyme previously shown to be associated with the pathogen response. RNA-Seq analyses demonstrated that over-express
Externí odkaz:
https://doaj.org/article/6b3e9de53b0a41299e3fceab9a234dee
Publikováno v:
European Journal of Organic Chemistry, 2022, Vol.2022(47) [Peer Reviewed Journal]
The iridium catalysed C−H borylation of polyfluorinated arenes and heteroarenes occurs rapidly and efficiently. As with other borylation reactions, whilst steric parameters dominate, an underlying electronic influence on reaction selectivity can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb28e69ca3319cdc893c7f97414d14
https://doi.org/10.1002/ejoc.202201005
https://doi.org/10.1002/ejoc.202201005
