Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Patrick G. Morris"'
Autor:
Gavin P. Dowling, Sinead Toomey, Philip Bredin, Imelda Parker, Eibhlin Mulroe, Jacinta Marron, Olivia McLoughlin, Ausra Teiserskiene, Colm Power, Anne Marie O’Shea, Megan Greally, Patrick G. Morris, Deirdre Duke, Arnold D. K. Hill, Bryan T. Hennessy
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significan
Externí odkaz:
https://doaj.org/article/525da2fab1674ea289c10763a6526868
Autor:
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments i
Externí odkaz:
https://doaj.org/article/2aa94f4a6ce8446ea48464a6049912d0
Autor:
Christopher Cronin, Ronan McLaughlin, Louise Lane, Francesca M. Brett, Michael Jansen, Niamh Bermingham, Gerald Wyse, Liam Grogan, Patrick G. Morris, Seamus O’Reilly
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BRAF V600E oncogene mutations have been reported in multiple central nervous system (CNS) tumor types, and emerging evidence supports the use of targeted therapy in BRAF-mutated gliomas. BRAF oncogene mutations have been recently identified in Rosai-
Externí odkaz:
https://doaj.org/article/864a4299c96e44de86938ece69ecbea1
Autor:
M. Janusz Mezynski, Angela M. Farrelly, Mattia Cremona, Aoife Carr, Clare Morgan, Julie Workman, Paul Armstrong, Jennifer McAuley, Stephen Madden, Joanna Fay, Katherine M. Sheehan, Elaine W. Kay, Ciara Holohan, Yasir Elamin, Shereen Rafee, Patrick G. Morris, Oscar Breathnach, Liam Grogan, Bryan T. Hennessy, Sinead Toomey
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Aberrant PI3K signalling is implicated in trastuzumab resistance in HER2-positive gastric cancer (GC). The role of PI3K or MEK inhibitors in sensitising HER2-positive GCs to trastuzumab or in overcoming trastuzumab resistance is u
Externí odkaz:
https://doaj.org/article/d5312ba8bd22456eb68ea89c9e9a8189
Autor:
Rachel J. Keogh, Razia Aslam, Maeve A. Hennessy, Zac Coyne, Bryan T. Hennessy, Oscar S. Breathnach, Liam Grogan, Patrick G. Morris
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, 1 year of PCV is associated with significant toxicities. In the pivotal RTO
Externí odkaz:
https://doaj.org/article/8a8e86d631dc496780b61a82416dbf04
Autor:
Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O’Byrne, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Alexander J. Eustace, Joanna Fay, Robert Cummins, Anthony O’Grady, Roshni Kalachand, Norma O’Donovan, Fergal Kelleher, Aine O’Reilly, Mark Doherty, John Crown, Bryan T. Hennessy
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutation
Externí odkaz:
https://doaj.org/article/b0a3ce4f632e46aeb43bc18b4d3e61a7
Autor:
Susan L. Murray, Fergus E. Daly, Patrick O’Kelly, Eamonn O’Leary, Sandra Deady, James P. O’Neill, Alexander Dudley, Nicholas R. Rutledge, Aiden McCormick, Diarmuid D. Houlihan, Yvonne Williams, Patrick G. Morris, Siona Ni Raghallaigh, Fergal J. Moloney, Donal J. Sexton, Peter J. Conlon
Publikováno v:
Renal Failure, Vol 42, Iss 1, Pp 607-612 (2020)
Background Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of rapamycin inh
Externí odkaz:
https://doaj.org/article/fd306fefc3f54840a8a196dac010c600
Autor:
Jack Patrick Gleeson, Fergus Keane, Niamh M. Keegan, Emin Mammadov, Emily Harrold, Abdullah Alhusaini, Jeffrey Harte, Austin Eakin‐Love, Philip J. O'Halloran, Stephen MacNally, Bryan T. Hennessy, Oscar S. Breathnach, Liam Grogan, Patrick G. Morris
Publikováno v:
Cancer Medicine, Vol 9, Iss 2, Pp 469-475 (2020)
Abstract Introduction Bevacizumab has demonstrated activity in glioblastoma (GBM), but the true benefits and optimal dose‐schedule are debated. A lower dose‐schedule than standard‐dose bevacizumab (10 mg/kg 2‐weekly) might offer similar benef
Externí odkaz:
https://doaj.org/article/7160152b75c84accabe1ca9133765361
Autor:
Robert J. Smyth, Valentina Thomas, Joanna Fay, Ronan Ryan, Siobhan Nicholson, Ross K. Morgan, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 8, p 768 (2021)
Pulmonary enteric adenocarcinoma (PEAC) is a rare variant of lung adenocarcinoma first described in the early 1990s in a lung tumour with overlapping lung and small intestine features. It is a rare tumour with fewer than 300 cases described in the pu
Externí odkaz:
https://doaj.org/article/71b70eaa1a11479aa75bc369796ea2d5
Autor:
Niamh M. Keegan, Simon J. Furney, Janice M. Walshe, Giuseppe Gullo, M. John Kennedy, Diarmuid Smith, John McCaffrey, Catherine M. Kelly, Keith Egan, Jennifer Kerr, Mark Given, Peter O’Donovan, Andres Hernando, Ausra Teiserskiene, Imelda Parker, Elaine Kay, Angela Farrelly, Aoife Carr, Giulio Calzaferri, Ray McDermott, Maccon M. Keane, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Sinead Toomey, Bryan T. Hennessy
Publikováno v:
Cancers, Vol 13, Iss 6, p 1225 (2021)
Background: Activation of the phosphoinositide-3 kinase (PI3K) pathway is a resistance mechanism to anti-human epidermal growth factor receptor 2 (HER2) therapy. This phase Ib trial was conducted to determine the maximum tolerated dose (MTD) of copan
Externí odkaz:
https://doaj.org/article/866b588805c44d53b259bc41e6f9fa7e