Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Patrick G. Mitchell"'
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a genetic mutation in the huntingtin gene (HTT). Here, cryo electron tomography provides insights into the morphology of the cells derived from patients with HD and mouse mod
Externí odkaz:
https://doaj.org/article/27dd4928dbf643889186e8bd55e8a97e
Publikováno v:
Nature Structural & Molecular Biology.
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313875dd4f14f417b710f2f394017c4
https://doi.org/10.1101/2022.03.26.485912
https://doi.org/10.1101/2022.03.26.485912
Autor:
Patrick G. Mitchell, Kaiming Zhang, Yee-Ting Li, Corey W. Hecksel, Grigore D. Pintilie, Wah Chiu
Publikováno v:
Microscopy and Microanalysis. 27:1152-1154
Autor:
Peter D. Dahlberg, Patrick G. Mitchell, Wah Chiu, Lucy Shapiro, W. E. Moerner, Jiarui Wang, Annina M. Sartor, Saumya Saurabh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The correlation of cryogenic superresolution fluorescence imaging, which features single-molecule sensitivity and specific labelling, with the molecular-scale cellular context of cryogenic electron tomography is a powerful approach for o
Publikováno v:
Ultramicroscopy. 235:113474
Autor:
Weijie Zhang, Xiang Zhang, Wah Chiu, Fabio Stossi, Luyu Jia, Hai Wang, Patrick G. Mitchell, Wei Dai, Michael A. Mancini, Aaron M. Muscarella
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
npj Breast Cancer, Vol 6, Iss 1, Pp 1-12 (2020)
Migration and invasion are key properties of metastatic cancer cells. These properties can be acquired through intrinsic reprogramming processes such as epithelial-mesenchymal transition. In this study, we discovered an alternative “migration-by-te
Autor:
Wah Chiu, Vimal Gangadharan, Emily M. Sontag, David Mankus, Abigail K. R. Lytton-Jean, Jesús G. Galaz-Montoya, Jeffrey Marshman, Margaret E. Bisher, Corey W. Hecksel, Patrick G. Mitchell, Gong-Her Wu, Judith Frydman, Kirk J. Czymmek
Publikováno v:
Structure
SUMMARYThree-dimensional (3D) visualization of vitrified cells can uncover structures of subcellular complexes without chemical fixation or staining. Here, we present a pipeline integrating three imaging modalities to visualize the same specimen at c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11aeb1368c979e5c4107db01430cf3e
https://doi.org/10.1101/2020.05.21.107771
https://doi.org/10.1101/2020.05.21.107771
Publikováno v:
Ultramicroscopy
Electron crystallography has recently gained attentions in multiple fields of research, as it has been demonstrated to determine atomic structures for inorganic, organic, and macromolecular materials from nano-sized crystals that were not amenable to
Autor:
Patrick G. Mitchell, Wah Chiu, Michele C. Darrow, Wei Dai, Corey W. Hecksel, Shurui Chen, Jessica A. Chin, Michael F. Schmid, Jemba Jakana, Jesús G. Galaz-Montoya
Publikováno v:
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 22(3)
Although acknowledged to be variable and subjective, manual annotation of cryo-electron tomography data is commonly used to answer structural questions and to create a “ground truth” for evaluation of automated segmentation algorithms. Validation